Cholesterol oxidase

Details

Name
Cholesterol oxidase
Synonyms
  • 1.1.3.6
  • CHOD
  • Cholesterol isomerase
Gene Name
choA
Organism
Streptomyces sp. (strain SA-COO)
Amino acid sequence
>lcl|BSEQ0019134|Cholesterol oxidase
MTAQQHLSRRRMLGMAAFGAAALAGGTTIAAPRAAAAAKSAADNGGYVPAVVIGTGYGAA
VSALRLGEAGVQTLMLEMGQLWNQPGPDGNIFCGMLNPDKRSSWFKNRTEAPLGSFLWLD
VVNRNIDPYAGVLDRVNYDQMSVYVGRGVGGGSLVNGGMAVEPKRSYFEEILPRVDSSEM
YDRYFPRANSMLRVNHIDTKWFEDTEWYKFARVSREQAGKAGLGTVFVPNVYDFGYMQRE
AAGEVPKSALATEVIYGNNHGKQSLDKTYLAAALGTGKVTIQTLHQVKTIRQTKDGGYAL
TVEQKDTDGKLLATKEISCRYLFLGAGSLGSTELLVRARDTGTLPNLNSEVGAGWGPNGN
IMTARANHMWNPTGAHQSSIPALGIDAWDNSDSSVFAEIAPMPAGLETWVSLYLAITKNP
QRGTFVYDAATDRAKLNWTRDQNAPAVNAAKALFDRINKANGTIYRYDLFGTQLKAFADD
FCYHPLGGCVLGKATDDYGRVAGYKNLYVTDGSLIPGSVGVNPFVTITALAERNVERIIK
QDVTAS
Number of residues
546
Molecular Weight
58993.275
Theoretical pI
8.49
GO Classification
Functions
cholesterol oxidase activity / flavin adenine dinucleotide binding / steroid delta-isomerase activity
Processes
cholesterol metabolic process
Components
extracellular region
General Function
Steroid delta-isomerase activity
Specific Function
Bifunctional enzyme that catalyzes the oxidation of the 3-beta-hydroxy group of cholesterol and the isomerization of the double bond of the resulting product.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0003077|1641 bp
GTGACTGCACAACAGCACCTGTCCCGCCGCCGCATGCTCGGCATGGCCGCCTTCGGCGCC
GCCGCCCTCGCCGGGGGCACCACCATCGCCGCCCCCCGTGCGGCCGCCGCCGCCAAGTCC
GCGGCGGACAACGGCGGTTACGTCCCCGCCGTCGTCATCGGCACCGGCTACGGCGCGGCC
GTCTCCGCGCTGCGCCTCGGCGAGGCGGGTGTGCAGACCCTGATGCTGGAGATGGGCCAG
CTGTGGAACCAGCCCGGCCCCGACGGCAACATCTTCTGCGGCATGCTCAACCCGGACAAG
CGGTCCAGCTGGTTCAAGAACCGCACCGAGGCCCCGCTCGGCAGCTTCCTCTGGCTCGAC
GTCGTCAACCGGAACATCGACCCCTACGCGGGTGTCCTGGACCGTGTGAACTACGACCAG
ATGTCGGTCTACGTGGGCCGCGGCGTCGGCGGCGGCTCGCTCGTCAACGGCGGCATGGCC
GTGGAGCCCAAGCGCTCGTACTTCGAGGAGATCCTCCCGCGGGTCGACTCCTCCGAGATG
TACGACCGCTACTTCCCCCGCGCCAACTCCATGCTCCGCGTCAACCACATCGACACCAAG
TGGTTCGAGGACACCGAGTGGTACAAGTTCGCCCGCGTCTCGCGCGAGCAGGCGGGCAAG
GCCGGTCTCGGCACCGTCTTCGTCCCCAACGTCTACGACTTCGGCTACATGCAGCGCGAG
GCCGCGGGCGAGGTGCCCAAGTCCGCCCTGGCGACCGAGGTCATCTACGGCAACAACCAC
GGCAAGCAGAGCCTGGACAAGACCTACCTGGCCGCCGCACTCGGCACCGGCAAGGTCACC
ATCCAGACCCTGCACCAGGTCAAGACGATCCGTCAGACGAAGGACGGCGGCTACGCGCTG
ACCGTCGAGCAGAAGGACACCGACGGCAAGCTCCTGGCCACCAAGGAGATCTCCTGCCGC
TACCTGTTCCTCGGCGCGGGCAGCCTCGGCTCCACCGAACTGCTGGTGCGCGCCCGCGAC
ACCGGCACCCTGCCGAACCTCAACTCCGAGGTGGGCGCGGGCTGGGGCCCCAACGGCAAC
ATCATGACCGCCCGGGCCAACCACATGTGGAACCCCACCGGCGCCCACCAGTCCTCCATC
CCCGCCCTCGGCATCGACGCGTGGGACAACAGCGACTCCTCGGTCTTCGCGGAGATCGCC
CCCATGCCGGCCGGCCTGGAGACGTGGGTCAGCCTCTACCTCGCGATCACCAAGAACCCC
CAGCGCGGCACCTTCGTGTACGACGCCGCGACGGACCGCGCGAAGCTCAACTGGACCCGT
GACCAGAACGCCCCCGCGGTCAACGCAGCCAAGGCGCTGTTCGACCGGATCAACAAGGCG
AACGGCACGATCTACCGGTACGACCTCTTCGGCACCCAGCTGAAGGCCTTCGCCGACGAC
TTCTGCTACCACCCGCTCGGCGGCTGCGTCCTGGGCAAGGCGACGGACGACTACGGCCGC
GTCGCCGGTTACAAGAACCTCTACGTGACCGACGGTTCGCTGATCCCGGGTTCCGTCGGC
GTCAACCCGTTCGTGACCATCACGGCGCTGGCCGAGCGGAACGTCGAGCGCATCATCAAG
CAGGACGTCACGGCGTCGTAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP12676
UniProtKB Entry NameCHOD_STRS0
GenBank Protein ID153212
GenBank Gene IDM31939
General References
  1. Ishizaki T, Hirayama N, Shinkawa H, Nimi O, Murooka Y: Nucleotide sequence of the gene for cholesterol oxidase from a Streptomyces sp. J Bacteriol. 1989 Jan;171(1):596-601. [Article]
  2. Yue QK, Kass IJ, Sampson NS, Vrielink A: Crystal structure determination of cholesterol oxidase from Streptomyces and structural characterization of key active site mutants. Biochemistry. 1999 Apr 6;38(14):4277-86. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB02332Flavin-N7 protonated-adenine dinucleotideexperimentalunknownDetails
DB03147Flavin adenine dinucleotideapprovedunknownDetails