Cytochrome P450 2B9
Details
- Name
- Cytochrome P450 2B9
- Synonyms
- 1.14.14.1
- Cyp2b-9
- CYPIIB9
- Cytochrome P450 clone PF26
- Cytochrome P450-16-alpha
- Rip
- Testosterone 16-alpha hydroxylase
- Gene Name
- Cyp2b9
- Organism
- Mouse
- Amino acid sequence
>lcl|BSEQ0017528|Cytochrome P450 2B9 MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPHPLPLLGNLLQMDRGGLLKCFIQLQE KHGDVFTVHLGPRPVVVLCGTQTIREALVDHAEAFSGRGTIAAAQLVMQDYGIFFASGQR WKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKYQGVPLDPTFLFQCITANIIC SIVFGERFDYTDDQFLHLLNLMYKIFSLLSSFSGQMFELFSGFLKYFPGVHRQIVKKQQE LLDYIAHSVEKHKATLDPSAPRDYIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGT ETTSATLHYGVLLMLKYPHVTEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFS DLVPIGLPHKVIKDTLFRGYLLPKNTEVYPVLSSALHDPQYFEQPDKFNPEHFLDANGAL KKCEAFLPFSTGKRICLGESIARNELFIFFTTILQNFSVASPVAPKDIDLTPKESGIGKI PPAHQIYFLAR
- Number of residues
- 491
- Molecular Weight
- 55740.36
- Theoretical pI
- Not Available
- GO Classification
- Functionsarachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activityProcessesepoxygenase P450 pathway / exogenous drug catabolic process / oxidation-reduction process / response to stilbenoid / xenobiotic metabolic processComponentscytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
- General Function
- Steroid hydroxylase activity
- Specific Function
- Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0017529|Cytochrome P450 2B9 (Cyp2b9) ATGGATCCTAGTGTCCTGCTCCTCCTTGCTGTCCTTCTGAGCTTATTTCTACTCCTGGTC AGGGGCCATGCAAAGATCCATGGCCATCTTCCACCAGGACCCCATCCTCTACCCCTCTTG GGGAACCTGTTGCAGATGGATAGAGGAGGCCTTCTTAAGTGTTTCATTCAGCTTCAAGAA AAACATGGAGATGTGTTCACAGTGCACTTGGGACCGAGGCCCGTGGTTGTGTTGTGTGGG ACACAGACGATAAGGGAGGCTCTGGTGGACCACGCTGAGGCTTTTTCTGGCCGAGGGACC ATTGCTGCAGCTCAGCTAGTTATGCAGGACTATGGTATATTTTTTGCCAGTGGGCAACGC TGGAAGACCCTTCGGCGATTCTCTCTGGCCACCATGAAAGAGTTTGGAATGGGAAAGCGG AGTGTGGAGGAGAGGATAAAGGAGGAGGCCCAATGTTTGGTGGAGGAATTGAAGAAATAC CAGGGAGTGCCCCTGGATCCCACCTTTCTCTTCCAGTGCATCACAGCCAACATCATCTGC TCCATTGTCTTTGGAGAGCGTTTTGACTACACAGATGACCAGTTCCTTCATCTGCTGAAT CTGATGTATAAGATCTTTTCACTCTTAAGCTCATTCTCTGGTCAGATGTTTGAGCTCTTC TCTGGATTCCTGAAGTACTTTCCTGGTGTACACAGACAAATTGTCAAAAAACAGCAGGAA CTCCTCGACTACATTGCCCATAGTGTGGAGAAGCACAAGGCCACCTTGGACCCCAGTGCT CCACGAGACTACATTGATACCTACCTTCTGAGGATGGAGAAGGAGAAGTCAAACCACAAC ACAGAGTTCCATCACCAGAACCTCATGATGTCTGTGCTCTCTCTCTTCTTTGCTGGAACT GAGACCACAAGCGCCACCCTCCACTATGGAGTCCTGCTCATGCTCAAGTACCCCCATGTC ACAGAGAAAGTCCAAAAGGAGATTGATCAGGTGATCGGCTCACACCGGCTACCAACTCTT GATGACCGCACCAAAATGCCATACACAGATGCAGTCATCCATGAGATTCAGAGATTTTCA GATCTTGTCCCAATTGGTCTACCACATAAAGTCATCAAAGACACACTGTTCCGAGGGTAC CTGCTCCCCAAGAACACTGAGGTGTACCCCGTCCTTAGTTCAGCTCTACATGATCCACAG TACTTTGAACAACCAGACAAGTTCAATCCTGAGCACTTTCTAGATGCCAATGGGGCACTG AAGAAATGTGAAGCTTTTCTGCCCTTCTCCACAGGAAAGCGCATTTGTCTTGGTGAAAGC ATTGCCCGCAACGAATTGTTCATTTTCTTCACAACCATTCTCCAGAACTTCTCTGTGGCA AGCCCTGTTGCTCCAAAGGACATTGACCTCACTCCCAAAGAGAGTGGTATTGGAAAAATA CCTCCAGCACACCAGATCTACTTCTTAGCCCGCTAA
- Chromosome Location
- 7
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P12790 UniProtKB Entry Name CP2B9_MOUSE - General References
- Noshiro M, Lakso M, Kawajiri K, Negishi M: Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Biochemistry. 1988 Aug 23;27(17):6434-43. [Article]
- Lakso M, Masaki R, Noshiro M, Negishi M: Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution. Eur J Biochem. 1991 Jan 30;195(2):477-86. [Article]
- Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details