Cytochrome P450 2B9

Details

Name
Cytochrome P450 2B9
Synonyms
  • 1.14.14.1
  • Cyp2b-9
  • CYPIIB9
  • Cytochrome P450 clone PF26
  • Cytochrome P450-16-alpha
  • Rip
  • Testosterone 16-alpha hydroxylase
Gene Name
Cyp2b9
Organism
Mouse
Amino acid sequence
>lcl|BSEQ0017528|Cytochrome P450 2B9
MDPSVLLLLAVLLSLFLLLVRGHAKIHGHLPPGPHPLPLLGNLLQMDRGGLLKCFIQLQE
KHGDVFTVHLGPRPVVVLCGTQTIREALVDHAEAFSGRGTIAAAQLVMQDYGIFFASGQR
WKTLRRFSLATMKEFGMGKRSVEERIKEEAQCLVEELKKYQGVPLDPTFLFQCITANIIC
SIVFGERFDYTDDQFLHLLNLMYKIFSLLSSFSGQMFELFSGFLKYFPGVHRQIVKKQQE
LLDYIAHSVEKHKATLDPSAPRDYIDTYLLRMEKEKSNHNTEFHHQNLMMSVLSLFFAGT
ETTSATLHYGVLLMLKYPHVTEKVQKEIDQVIGSHRLPTLDDRTKMPYTDAVIHEIQRFS
DLVPIGLPHKVIKDTLFRGYLLPKNTEVYPVLSSALHDPQYFEQPDKFNPEHFLDANGAL
KKCEAFLPFSTGKRICLGESIARNELFIFFTTILQNFSVASPVAPKDIDLTPKESGIGKI
PPAHQIYFLAR
Number of residues
491
Molecular Weight
55740.36
Theoretical pI
Not Available
GO Classification
Functions
arachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activity
Processes
epoxygenase P450 pathway / exogenous drug catabolic process / oxidation-reduction process / response to stilbenoid / xenobiotic metabolic process
Components
cytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
General Function
Steroid hydroxylase activity
Specific Function
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0017529|Cytochrome P450 2B9 (Cyp2b9)
ATGGATCCTAGTGTCCTGCTCCTCCTTGCTGTCCTTCTGAGCTTATTTCTACTCCTGGTC
AGGGGCCATGCAAAGATCCATGGCCATCTTCCACCAGGACCCCATCCTCTACCCCTCTTG
GGGAACCTGTTGCAGATGGATAGAGGAGGCCTTCTTAAGTGTTTCATTCAGCTTCAAGAA
AAACATGGAGATGTGTTCACAGTGCACTTGGGACCGAGGCCCGTGGTTGTGTTGTGTGGG
ACACAGACGATAAGGGAGGCTCTGGTGGACCACGCTGAGGCTTTTTCTGGCCGAGGGACC
ATTGCTGCAGCTCAGCTAGTTATGCAGGACTATGGTATATTTTTTGCCAGTGGGCAACGC
TGGAAGACCCTTCGGCGATTCTCTCTGGCCACCATGAAAGAGTTTGGAATGGGAAAGCGG
AGTGTGGAGGAGAGGATAAAGGAGGAGGCCCAATGTTTGGTGGAGGAATTGAAGAAATAC
CAGGGAGTGCCCCTGGATCCCACCTTTCTCTTCCAGTGCATCACAGCCAACATCATCTGC
TCCATTGTCTTTGGAGAGCGTTTTGACTACACAGATGACCAGTTCCTTCATCTGCTGAAT
CTGATGTATAAGATCTTTTCACTCTTAAGCTCATTCTCTGGTCAGATGTTTGAGCTCTTC
TCTGGATTCCTGAAGTACTTTCCTGGTGTACACAGACAAATTGTCAAAAAACAGCAGGAA
CTCCTCGACTACATTGCCCATAGTGTGGAGAAGCACAAGGCCACCTTGGACCCCAGTGCT
CCACGAGACTACATTGATACCTACCTTCTGAGGATGGAGAAGGAGAAGTCAAACCACAAC
ACAGAGTTCCATCACCAGAACCTCATGATGTCTGTGCTCTCTCTCTTCTTTGCTGGAACT
GAGACCACAAGCGCCACCCTCCACTATGGAGTCCTGCTCATGCTCAAGTACCCCCATGTC
ACAGAGAAAGTCCAAAAGGAGATTGATCAGGTGATCGGCTCACACCGGCTACCAACTCTT
GATGACCGCACCAAAATGCCATACACAGATGCAGTCATCCATGAGATTCAGAGATTTTCA
GATCTTGTCCCAATTGGTCTACCACATAAAGTCATCAAAGACACACTGTTCCGAGGGTAC
CTGCTCCCCAAGAACACTGAGGTGTACCCCGTCCTTAGTTCAGCTCTACATGATCCACAG
TACTTTGAACAACCAGACAAGTTCAATCCTGAGCACTTTCTAGATGCCAATGGGGCACTG
AAGAAATGTGAAGCTTTTCTGCCCTTCTCCACAGGAAAGCGCATTTGTCTTGGTGAAAGC
ATTGCCCGCAACGAATTGTTCATTTTCTTCACAACCATTCTCCAGAACTTCTCTGTGGCA
AGCCCTGTTGCTCCAAAGGACATTGACCTCACTCCCAAAGAGAGTGGTATTGGAAAAATA
CCTCCAGCACACCAGATCTACTTCTTAGCCCGCTAA
Chromosome Location
7
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP12790
UniProtKB Entry NameCP2B9_MOUSE
General References
  1. Noshiro M, Lakso M, Kawajiri K, Negishi M: Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA. Biochemistry. 1988 Aug 23;27(17):6434-43. [Article]
  2. Lakso M, Masaki R, Noshiro M, Negishi M: Structures and characterization of sex-specific mouse cytochrome P-450 genes as members within a large family. Duplication boundary and evolution. Eur J Biochem. 1991 Jan 30;195(2):477-86. [Article]
  3. Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [Article]
  4. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  5. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails