Beta-3 adrenergic receptor

Details

Name
Beta-3 adrenergic receptor
Synonyms
  • ADRB3R
  • B3AR
  • Beta-3 adrenoceptor
  • Beta-3 adrenoreceptor
Gene Name
ADRB3
Organism
Human
Amino acid sequence
>lcl|BSEQ0010709|Beta-3 adrenergic receptor
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIV
AIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLC
VTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRV
GADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRG
ELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGT
FTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLL
CRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
Number of residues
408
Molecular Weight
43518.615
Theoretical pI
9.07
GO Classification
Functions
beta-adrenergic receptor activity / beta3-adrenergic receptor activity / epinephrine binding / protein homodimerization activity / norepinephrine binding
Processes
diet induced thermogenesis / generation of precursor metabolites and energy / energy reserve metabolic process / heat generation / G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / negative regulation of multicellular organism growth / response to antibiotic / aging / response to cold / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure / temperature homeostasis / eating behavior / positive regulation of MAPK cascade / cell-cell signaling / carbohydrate metabolic process / adenylate cyclase-activating adrenergic receptor signaling pathway / brown fat cell differentiation / activation of adenylate cyclase activity
Components
nucleus / plasma membrane / receptor complex / integral component of plasma membrane
General Function
Protein homodimerization activity
Specific Function
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Pfam Domain Function
Transmembrane Regions
37-63 73-91 112-133 156-178 204-225 293-314 327-347
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0010710|Beta-3 adrenergic receptor (ADRB3)
ATGGCTCCGTGGCCTCACGAGAACAGCTCTCTTGCCCCATGGCCGGACCTCCCCACCCTG
GCGCCCAATACCGCCAACACCAGTGGGCTGCCAGGGGTTCCGTGGGAGGCGGCCCTAGCC
GGGGCCCTGCTGGCGCTGGCGGTGCTGGCCACCGTGGGAGGCAACCTGCTGGTCATCGTG
GCCATCGCCTGGACTCCGAGACTCCAGACCATGACCAACGTGTTCGTGACTTCGCTGGCC
GCAGCCGACCTGGTGATGGGACTCCTGGTGGTGCCGCCGGCGGCCACCTTGGCGCTGACT
GGCCACTGGCCGTTGGGCGCCACTGGCTGCGAGCTGTGGACCTCGGTGGACGTGCTGTGT
GTGACCGCCAGCATCGAAACCCTGTGCGCCCTGGCCGTGGACCGCTACCTGGCTGTGACC
AACCCGCTGCGTTACGGCGCACTGGTCACCAAGCGCTGCGCCCGGACAGCTGTGGTCCTG
GTGTGGGTCGTGTCGGCCGCGGTGTCGTTTGCGCCCATCATGAGCCAGTGGTGGCGCGTA
GGGGCCGACGCCGAGGCGCAGCGCTGCCACTCCAACCCGCGCTGCTGTGCCTTCGCCTCC
AACATGCCCTACGTGCTGCTGTCCTCCTCCGTCTCCTTCTACCTTCCTCTTCTCGTGATG
CTCTTCGTCTACGCGCGGGTTTTCGTGGTGGCTACGCGCCAGCTGCGCTTGCTGCGCGGG
GAGCTGGGCCGCTTTCCGCCCGAGGAGTCTCCGCCGGCGCCGTCGCGCTCTCTGGCCCCG
GCCCCGGTGGGGACGTGCGCTCCGCCCGAAGGGGTGCCCGCCTGCGGCCGGCGGCCCGCG
CGCCTCCTGCCTCTCCGGGAACACCGGGCCCTGTGCACCTTGGGTCTCATCATGGGCACC
TTCACTCTCTGCTGGTTGCCCTTCTTTCTGGCCAACGTGCTGCGCGCCCTGGGGGGCCCC
TCTCTAGTCCCGGGCCCGGCTTTCCTTGCCCTGAACTGGCTAGGTTATGCCAATTCTGCC
TTCAACCCGCTCATCTACTGCCGCAGCCCGGACTTTCGCAGCGCCTTCCGCCGTCTTCTG
TGCCGCTGCGGCCGTCGCCTGCCTCCGGAGCCCTGCGCCGCCGCCCGCCCGGCCCTCTTC
CCCTCGGGCGTTCCTGCGGCCCGGAGCAGCCCAGCGCAGCCCAGGCTTTGCCAACGGCTC
GACGGGGCTTCTTGGGGAGTTTCTTAG
Chromosome Location
8
Locus
8p12-p11.2
External Identifiers
ResourceLink
UniProtKB IDP13945
UniProtKB Entry NameADRB3_HUMAN
GenBank Protein ID178896
GenBank Gene IDM29932
GenAtlas IDADRB3
HGNC IDHGNC:288
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00368NorepinephrineapprovedyesagonistDetails
DB00571Propranololapproved, investigationalunknownantagonistDetails
DB05395AmibegroninvestigationalunknownDetails
DB06262Droxidopaapproved, investigationalyesagonistDetails
DB06190SolabegroninvestigationalunknownagonistDetails
DB01288Fenoterolapproved, investigationalunknownagonistDetails
DB01407Clenbuterolapproved, investigational, vet_approvedunknownagonistDetails
DB01102ArbutamineapprovedunknownagonistDetails
DB01064Isoprenalineapproved, investigationalyesagonistDetails
DB08807BopindololapprovedunknownDetails
DB08808BupranololapprovedunknownantagonistDetails
DB01363Ephedraapproved, nutraceutical, withdrawnyesagonistDetails
DB08893MirabegronapprovedyesagonistDetails
DB00668Epinephrineapproved, vet_approvedunknownagonistDetails
DB01001Salbutamolapproved, vet_approvedunknownDetails
DB00866Alprenololapproved, withdrawnunknownantagonistDetails
DB00983Formoterolapproved, investigationalunknownagonistDetails
DB00938SalmeterolapprovedunknownagonistDetails
DB00871TerbutalineapprovedunknownagonistDetails
DB00960Pindololapproved, investigationalunknownagonistDetails
DB01580OxprenololapprovedunknownDetails
DB11124RacepinephrineapprovedyesagonistDetails
DB00182Amphetamineapproved, illicit, investigationalunknownagonistDetails
DB00540NortriptylineapprovedunknownantagonistDetails
DB00726TrimipramineapprovedunknownbinderDetails
DB00334Olanzapineapproved, investigationalunknowninhibitorDetails
DB00217BethanidineapprovedunknownantagonistDetails
DB00321AmitriptylineapprovedunknownbinderDetails
DB01365MephentermineapprovedunknownagonistDetails
DB06726Bufuralolexperimental, investigationalunknownantagonistDetails
DB13345Dihydroergocristineapproved, experimentalyesantagonistagonistDetails
DB01049Ergoloid mesylateapprovedyesantagonistagonistDetails
DB11273DihydroergocornineapprovedyesantagonistagonistDetails
DB11278DL-MethylephedrineapprovedyesagonistDetails