Tubulin alpha chain

Details

Name

Tubulin alpha chain

Synonyms

Not Available

Gene Name

Not Available

Organism

Plasmodium falciparum (isolate K1 / Thailand)

Amino acid sequence

>lcl|BSEQ0051389|Tubulin alpha chain
MREVISIHVGQAGIQVGNACWELFCLEHGIQPDGQMPSDKASRANDDAFNTFFSETGAGK
HVPRCVFVDLEPTVVDEVRTGTYRQLFHPEQLISGKEDAANNFARGHYTIGKEVIDVCLD
RIRKLADNCTGLQGFLMFSAVGGGTGSGFGCLMLERLSVDYGKKSKLNFCCWPSPQVSTA
VVEPYNSVLSTHSLLEHTDVAIMLDNEAIYDICRRNLDIERPTYTNLNRLIAQVISSLTA
SLRFDGALNVDVTEFQTNLVPYPRIHFMLSSYAPVVSAEKAYHEQLSVSEITNSAFEPAN
MMAKCDPRHGKYMACCLMYRGDVVPKDVNAAVATIKTKRTIQFVDWCPTGFKCGINYQPP
TVVPGGDLAKVMRAVCMISNSTAIAEVFSRMDQKFDLMYAKRAFVHWYVGEGMEEGEFSE
AREDLAALEKDYEEVGIESNEAEGEDEGYEADY

Number of residues

453

Molecular Weight

50296.57

Theoretical pI

Not Available

GO Classification

Functions

GTP binding / GTPase activity / structural constituent of cytoskeleton

Processes

microtubule-based process

Components

cytoplasm / microtubule

General Function

Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

Specific Function

Gtp binding

Pfam Domain Function

• Tubulin (PF00091)
• Tubulin_C (PF03953)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P14642
UniProtKB Entry Name	TBA_PLAFK

General References

1. Holloway SP, Sims PF, Delves CJ, Scaife JG, Hyde JE: Isolation of alpha-tubulin genes from the human malaria parasite, Plasmodium falciparum: sequence analysis of alpha-tubulin. Mol Microbiol. 1989 Nov;3(11):1501-10. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB11638	Artenimol	approved, experimental, investigational	unknown	ligand	Details