Cytochrome P450 2A2
Details
- Name
- Cytochrome P450 2A2
- Synonyms
- 1.14.14.1
- Cyp2a-2
- CYPIIA2
- Cytochrome P450-UT-4
- Testosterone 15-alpha-hydroxylase
- Gene Name
- Cyp2a2
- Organism
- Rat
- Amino acid sequence
>lcl|BSEQ0013304|Cytochrome P450 2A2 MLDTGLLLVVILASLSVMFLVSLWQQKIRERLPPGPTPLPFIGNYLQLNMKDVYSSITQL SERYGPVFTIHLGPRRIVVLYGYDAVKEALVDQAEEFSGRGELPTFNILFKGYGFSLSNV EQAKRIRRFTIATLRDFGVGKRDVQECILEEAGYLIKTLQGTCGAPIDPSIYLSKTVSNV INSIVFGNRFDYEDKEFLSLLEMIDEMNIFAASATGQLYDMFHSVMKYLPGPQQQIIKVT QKLEDFMIEKVRQNHSTLDPNSPRNFIDSFLIRMQEEKYVNSEFHMNNLVMSSLGLLFAG TGSVSSTLYHGFLLLMKHPDVEAKVHEEIERVIGRNRQPQYEDHMKMPYTQAVINEIQRF SNLAPLGIPRRIIKNTTFRGFFLPKGTDVFPIIGSLMTEPKFFPNHKDFNPQHFLDDKGQ LKKNAAFLPFSIGKRFCLGDSLAKMELFLLLTTILQNFRFKFPMNLEDINEYPSPIGFTR IIPNYTMSFMPI
- Number of residues
- 492
- Molecular Weight
- 56344.975
- Theoretical pI
- Not Available
- GO Classification
- Functionsarachidonic acid epoxygenase activity / aromatase activity / heme binding / iron ion binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / oxygen binding / steroid hydroxylase activityProcessescoumarin metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / oxidation-reduction process / xenobiotic metabolic processComponentscytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
- General Function
- Steroid hydroxylase activity
- Specific Function
- Highly active in the 15-alpha-hydroxylation of testosterone.
- Pfam Domain Function
- p450 (PF00067)
- Transmembrane Regions
- Not Available
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0013305|Cytochrome P450 2A2 (Cyp2a2) ATGCTGGACACAGGACTGCTCCTGGTGGTCATACTGGCCTCCCTAAGTGTCATGTTCTTG GTGTCCCTCTGGCAGCAGAAAATCAGGGAGAGATTGCCTCCAGGACCCACTCCTTTGCCT TTCATTGGAAATTATCTGCAGCTGAATATGAAAGACGTATACAGTTCCATCACACAGCTC AGTGAGCGCTATGGTCCTGTGTTCACCATTCACCTTGGGCCTCGACGGATTGTTGTGCTT TATGGATACGATGCAGTCAAAGAGGCTTTGGTGGACCAAGCTGAGGAGTTCAGTGGACGT GGCGAACTGCCTACCTTTAATATACTCTTCAAAGGCTATGGTTTTTCATTGAGCAATGTG GAACAGGCCAAGCGTATCAGGCGCTTCACCATAGCCACATTGAGAGATTTTGGTGTGGGC AAGCGTGATGTACAGGAGTGTATCCTGGAGGAGGCAGGCTATTTGATCAAGACGTTGCAG GGCACTTGTGGAGCCCCCATTGACCCTTCCATCTACCTGAGCAAAACAGTCTCCAATGTC ATTAACTCCATTGTCTTCGGGAACCGCTTCGACTATGAGGACAAAGAGTTCTTGTCACTG TTGGAGATGATCGATGAAATGAATATATTTGCAGCCTCAGCCACAGGGCAGCTCTATGAC ATGTTCCATTCAGTGATGAAGTACCTGCCTGGACCACAGCAACAGATCATCAAGGTTACT CAGAAACTGGAAGACTTCATGATAGAGAAAGTGAGGCAGAACCATAGTACCCTGGACCCC AATTCCCCAAGGAACTTCATTGACTCCTTTCTCATCCGCATGCAAGAGGAGAAATATGTT AATTCAGAATTCCACATGAACAACCTAGTGATGTCATCATTAGGCCTCCTCTTTGCTGGG ACTGGGTCAGTCAGCTCCACGCTATACCATGGTTTCCTGCTACTCATGAAGCATCCAGAT GTGGAAGCCAAGGTCCATGAGGAAATTGAGCGAGTGATCGGCAGGAACCGACAGCCTCAG TATGAGGACCACATGAAGATGCCCTACACCCAGGCTGTGATCAATGAGATCCAAAGATTT TCTAACTTGGCTCCCTTGGGCATTCCTCGAAGGATTATCAAGAACACAACCTTCCGTGGC TTCTTCCTCCCCAAGGGCACCGATGTATTCCCTATAATAGGTTCTCTGATGACAGAACCA AAGTTCTTCCCTAACCACAAAGACTTCAACCCCCAGCACTTCCTGGATGACAAGGGACAG TTGAAGAAGAATGCTGCATTTCTCCCTTTTTCCATTGGAAAGCGATTCTGCTTGGGAGAT AGCCTGGCTAAAATGGAGCTCTTCCTGCTGCTCACCACCATCTTGCAGAACTTCCGTTTT AAGTTCCCAATGAATCTAGAAGACATCAACGAGTACCCCAGTCCCATAGGGTTTACCAGG ATCATACCAAATTACACCATGAGCTTCATGCCCATCTGA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P15149 UniProtKB Entry Name CP2A2_RAT - General References
- Matsunaga T, Nagata K, Holsztynska EJ, Lapenson DP, Smith A, Kato R, Gelboin HV, Waxman DJ, Gonzalez FJ: Gene conversion and differential regulation in the rat P-450 IIA gene subfamily. Purification, catalytic activity, cDNA and deduced amino acid sequence, and regulation of an adult male-specific hepatic testosterone 15 alpha-hydroxylase. J Biol Chem. 1988 Dec 5;263(34):17995-8002. [Article]
- Matsunaga T, Nomoto M, Kozak CA, Gonzalez FJ: Structure and in vitro transcription of the rat CYP2A1 and CYP2A2 genes and regional localization of the CYP2A gene subfamily on mouse chromosome 7. Biochemistry. 1990 Feb 6;29(5):1329-41. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Matsumoto T, Emi Y, Kawabata S, Omura T: Purification and characterization of three male-specific and one female-specific forms of cytochrome P-450 from rat liver microsomes. J Biochem. 1986 Nov;100(5):1359-71. [Article]
- Arlotto MP, Greenway DJ, Parkinson A: Purification of two isozymes of rat liver microsomal cytochrome P450 with testosterone 7 alpha-hydroxylase activity. Arch Biochem Biophys. 1989 May 1;270(2):441-57. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details