Carboxypeptidase N catalytic chain
Details
- Name
- Carboxypeptidase N catalytic chain
- Synonyms
- 3.4.17.3
- ACBP
- Anaphylatoxin inactivator
- Arginine carboxypeptidase
- Carboxypeptidase N polypeptide 1
- Carboxypeptidase N small subunit
- CPN
- Kininase-1
- Lysine carboxypeptidase
- Plasma carboxypeptidase B
- SCPN
- Serum carboxypeptidase N
- Gene Name
- CPN1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017120|Carboxypeptidase N catalytic chain MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHL YVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQD TRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPN HHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRT ASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHT NCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVIS VSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIP QVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA
- Number of residues
- 458
- Molecular Weight
- 52285.935
- Theoretical pI
- 7.36
- GO Classification
- Functionsmetallocarboxypeptidase activity / serine-type carboxypeptidase activity / zinc ion bindingProcessesbradykinin catabolic process / peptide metabolic process / protein processing / response to glucocorticoidComponentsextracellular space
- General Function
- Zinc ion binding
- Specific Function
- Protects the body from potent vasoactive and inflammatory peptides containing C-terminal Arg or Lys (such as kinins or anaphylatoxins) which are released into the circulation.
- Pfam Domain Function
- Peptidase_M14 (PF00246)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017121|Carboxypeptidase N catalytic chain (CPN1) ATGTCAGACCTGCTCTCAGTCTTCCTCCACCTCCTCCTTCTCTTCAAGTTGGTTGCCCCG GTGACCTTTCGCCACCACCGCTATGATGATCTTGTGCGGACGCTGTACAAGGTGCAAAAC GAATGCCCCGGCATCACGCGGGTCTACAGCATTGGGCGCAGCGTGGAGGGGAGACACCTC TACGTGCTGGAGTTCAGCGACCACCCTGGAATCCACGAGCCCTTGGAACCAGAGGTCAAG TATGTGGGGAACATGCACGGCAACGAAGCGTTGGGCCGCGAGCTGATGCTGCAGCTGTCG GAGTTTCTGTGCGAGGAGTTCCGGAACAGGAACCAGCGCATCGTCCAGCTCATCCAGGAC ACGCGCATTCACATCCTGCCATCCATGAACCCCGACGGCTACGAGGTGGCTGCTGCCCAG GGCCCAAACAAGCCTGGGTATCTAGTTGGCAGGAACAATGCAAATGGAGTGGACCTGAAC CGCAACTTCCCTGATCTCAATACCTATATCTACTATAACGAGAAGTACGGAGGCCCCAAC CACCACCTGCCCCTTCCAGACAACTGGAAAAGTCAGGTGGAACCCGAGACCCGGGCGGTG ATCCGGTGGATGCACTCCTTCAACTTTGTTCTTTCAGCCAATCTCCACGGAGGGGCGGTG GTGGCCAATTACCCGTATGACAAGTCCTTTGAGCACCGGGTCCGAGGGGTCCGCCGCACC GCCAGCACCCCCACGCCTGACGACAAGCTCTTCCAGAAGCTGGCCAAGGTCTACTCCTAT GCACATGGATGGATGTTCCAAGGTTGGAACTGCGGAGATTACTTCCCAGATGGCATCACC AATGGGGCTTCCTGGTATTCTCTCAGCAAGGGAATGCAAGACTTTAATTATCTCCATACC AACTGCTTTGAGATCACGCTGGAACTGAGTTGCGACAAGTTTCCCCCCGAAGAGGAGTTA CAGCGGGAGTGGCTGGGTAATCGGGAAGCCCTAATCCAGTTCCTGGAACAGGTTCACCAG GGCATCAAGGGAATGGTGCTTGATGAGAATTACAATAATCTCGCCAATGCTGTCATTTCT GTCAGTGGGATTAACCATGATGTCACTTCAGGTGACCATGGTGATTACTTCCGGCTGCTG CTTCCAGGTATCTACACTGTTAGTGCCACAGCACCTGGGTATGACCCAGAGACAGTAACT GTGACCGTGGGTCCTGCGGAACCAACGTTGGTTAACTTCCACCTCAAAAGAAGCATCCCT CAAGTAAGCCCTGTGAGGAGAGCTCCCAGCAGAAGGCACGGAGTCAGAGCCAAAGTGCAG CCCCAAGCCAGAAAGAAAGAAATGGAGATGAGGCAGCTGCAGAGAGGCCCTGCCTGA
- Chromosome Location
- 10
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P15169 UniProtKB Entry Name CBPN_HUMAN GenBank Gene ID BC027897 GenAtlas ID CPN1 HGNC ID HGNC:2312 - General References
- Gebhard W, Schube M, Eulitz M: cDNA cloning and complete primary structure of the small, active subunit of human carboxypeptidase N (kininase 1). Eur J Biochem. 1989 Jan 2;178(3):603-7. [Article]
- Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
- Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
- Skidgel RA, Bennett CD, Schilling JW, Tan FL, Weerasinghe DK, Erdos EG: Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. Biochem Biophys Res Commun. 1988 Aug 15;154(3):1323-9. [Article]
- Hendriks D, Vingron M, Vriend G, Wang W, Nalis D, Scharpe S: On the specificity of carboxypeptidase N, a comparative study. Biol Chem Hoppe Seyler. 1993 Sep;374(9):843-9. [Article]
- Keil C, Maskos K, Than M, Hoopes JT, Huber R, Tan F, Deddish PA, Erdos EG, Skidgel RA, Bode W: Crystal structure of the human carboxypeptidase N (kininase I) catalytic domain. J Mol Biol. 2007 Feb 16;366(2):504-16. Epub 2006 Nov 11. [Article]
- Cao H, Hegele RA: DNA polymorphism and mutations in CPN1, including the genomic basis of carboxypeptidase N deficiency. J Hum Genet. 2003;48(1):20-2. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB12271 ORE-1001 investigational unknown Details DB01593 Zinc approved, investigational unknown Details DB14487 Zinc acetate approved, investigational unknown Details DB14533 Zinc chloride approved, investigational unknown cofactor Details DB14548 Zinc sulfate, unspecified form approved, experimental unknown cofactor Details