Xylose isomerase

Details

Name
Xylose isomerase
Synonyms
  • 5.3.1.5
Gene Name
xylA
Organism
Streptomyces olivochromogenes
Amino acid sequence
>lcl|BSEQ0016389|Xylose isomerase
MSYQPTPEDRFTFGLWTVGWQGRDPFGDATRPALDPVETVQRLAELGAHGVTFHDDDLIP
FGSSDTERESHIKRFRQALDATGMTVPMATTNLFTHPVFKDGGFTANDRDVRRYALRKTI
RNIDLAVELGAKTYVAWGGREGAESGAAKDVRVALDRMKEAFDLLGEYVTSQGYDTRFAI
EPKPNEPRGDILLPTVGHALAFIERLERPELYGVNPEVGHEQMAGLNFPHGIAQALWAGK
LFHIDLNGQSGIKYDQDLRFGAGDLRAAFWLVDLLESAGYEGPRHFDFKPPRTEDIDGVW
ASAAGCMRNYLILKERAAAFRADPEVQEALRASRLDELAQPTAADGVQELLADRTAFEDF
DVDAAAARGMAFERLDQLAMDHLLGAR
Number of residues
387
Molecular Weight
42922.7
Theoretical pI
4.76
GO Classification
Functions
magnesium ion binding / xylose isomerase activity
Processes
D-xylose metabolic process / pentose-phosphate shunt
Components
cytoplasm
General Function
Xylose isomerase activity
Specific Function
Involved in D-xylose catabolism.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP15587
UniProtKB Entry NameXYLA_STROL
General References
  1. Lavie A, Allen KN, Petsko GA, Ringe D: X-ray crystallographic structures of D-xylose isomerase-substrate complexes position the substrate and provide evidence for metal movement during catalysis. Biochemistry. 1994 May 10;33(18):5469-80. [Article]
  2. Farber GK, Glasfeld A, Tiraby G, Ringe D, Petsko GA: Crystallographic studies of the mechanism of xylose isomerase. Biochemistry. 1989 Sep 5;28(18):7289-97. [Article]
  3. Farber GK, Petsko GA, Ringe D: The 3.0 A crystal structure of xylose isomerase from Streptomyces olivochromogenes. Protein Eng. 1987 Dec;1(6):459-66. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB11195Xylitolexperimental, investigationalunknownDetails
DB024383-O-Methylfructose in Linear FormexperimentalunknownDetails
DB02379Beta-D-GlucoseexperimentalunknownDetails