Cyclic AMP-dependent transcription factor ATF-7

Details

Synonyms

Activating transcription factor 7
ATFA
cAMP-dependent transcription factor ATF-7
Transcription factor ATF-A

Gene Name

ATF7

Organism

Humans

Amino acid sequence

>lcl|BSEQ0008703|Cyclic AMP-dependent transcription factor ATF-7
MGDDRPFVCNAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARTDSVIIADQTPTPTRFLKN
CEEVGLFNELASSFEHEFKKAADEDEKKARSRTVAKKLVAAAGPLDMSLPSTPDIKIKEE
EPVEVDSSPPDSPASSPCSPPLKEKEVTPKPVLISTPTPTIVRPGSLPLHLGYDPLHPTL
PSPTSVITQAPPSNRQMGSPTGSLPLVMHLANGQTMPVLPGPPVQMPSVISLARPVSMVP
NIPGIPGPPVNSSGSISPSGHPIPSEAKMRLKATLTHQVSSINGGCGMVVGTASTMVTAR
PEQSQILIQHPDAPSPAQPQVSPAQPTPSTGGRRRRTVDEDPDERRQRFLERNRAAASRC
RQKRKLWVSSLEKKAEELTSQNIQLSNEVTLLRNEVAQLKQLLLAHKDCPVTALQKKTQG
YLESPKESSEPTGSPAPVIQHSSATAPSNGLSVRSAAEAVATSVLTQMASQRTELSMPIQ
SHVIMTPQSQSAGR

Number of residues

494

Molecular Weight

52966.875

Theoretical pI

Not Available

GO Classification

Functions

DNA binding / DNA binding transcription factor activity / enzyme binding / metal ion binding / mitogen-activated protein kinase binding / RNA polymerase II proximal promoter sequence-specific DNA binding / transcription factor binding / transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

Processes

negative regulation of transcription from RNA polymerase II promoter / regulation of transcription, DNA-templated / transcription, DNA-templated / viral process

Components

cytoplasm / nuclear periphery / nucleoplasm / nucleus

General Function

Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. Activator of the NF-ELAM1/delta-A site of the E-selectin promoter. Has no intrinsic transcriptional activity, but activates transcription on formation of JUN or FOS heterodimers. Also can bind TRE promoter sequences when heterodimerized with members of the JUN family.

Specific Function

Dna binding

Pfam Domain Function

bZIP_1 (PF00170)

Transmembrane Regions

Not Available

Cellular Location

Nucleus

Gene sequence

>lcl|BSEQ0051556|Cyclic AMP-dependent transcription factor ATF-7 (ATF7)
ATGGGAGACGACAGACCGTTTGTGTGCAATGCCCCGGGCTGTGGACAGAGATTTACAAAC
GAGGACCACCTGGCAGTTCATAAACACAAGCATGAGATGACATTGAAATTTGGCCCAGCC
CGAACTGACTCAGTCATCATTGCAGATCAAACGCCTACTCCAACTAGATTCCTGAAGAAC
TGTGAGGAGGTGGGACTCTTCAATGAACTAGCTAGCTCCTTTGAACATGAATTCAAGAAA
GCTGCAGATGAGGATGAGAAAAAGGCTGCTGCTGGGCCCCTTGACATGTCTCTGCCTTCC
ACACCAGACATCAAAATCAAAGAAGAAGAGCCAGTGGAGGTAGACTCATCCCCACCTGAT
AGCCCTGCCTCTAGTCCCTGTTCCCCACCACTGAAGGAGAAGGAGGTTACCCCAAAGCCT
GTTCTGATCTCTACCCCCACACCCACCATTGTACGTCCTGGCTCCCTGCCTCTCCACTTG
GGCTATGATCCACTTCATCCAACCCTTCCCTCCCCAACCTCTGTCATCACACAGGCTCCA
CCATCCAACAGGCAAATGGGGTCTCCCACTGGCTCCCTCCCTCTTGTCATGCATCTTGCT
AATGGACAGACCATGCCTGTGTTGCCAGGGCCTCCAGTACAGATGCCGTCTGTTATATCG
CTGGCCAGACCTGTGTCCATGGTGCCCAACATTCCTGGTATCCCTGGCCCACCAGTTAAC
AGTAGTGGCTCCATTTCTCCCTCTGGCCACCCTATACCATCAGAAGCCAAGATGAGACTG
AAAGCCACCCTAACTCACCAAGTCTCCTCAATCAATGGTGGTTGTGGAATGGTGGTGGGT
ACTGCCAGCACCATGGTGACAGCCCGCCCAGAGCAGAGCCAGATTCTCATCCAGCACCCT
GATGCCCCATCCCCTGCCCAGCCACAGGTCTCACCAGCTCAGCCCACCCCTAGTACTGGG
GGGCGACGGCGGCGCACAGTAGATGAAGATCCAGATGAGCGACGGCAGCGCTTTCTGGAG
CGCAACCGGGCTGCAGCCTCCCGCTGCCGCCAAAAGCGAAAGCTGTGGGTGTCCTCCCTA
GAGAAGAAGGCCGAAGAACTCACTTCTCAGAACATTCAGCTGAGTAATGAAGTCACATTA
CTACGCAATGAGGTGGCCCAGTTGAAACAGCTACTGTTAGCTCATAAAGACTGCCCAGTC
ACTGCACTACAGAAAAAGACTCAAGGCTATTTAGAAAGCCCCAAGGAAAGCTCAGAGCCA
ACGGGTTCTCCAGCCCCTGTGATTCAGCACAGCTCAGCAACAGCCCCTAGCAATGGCCTC
AGTGTTCGCTCTGCAGCTGAAGCTGTGGCCACCTCGGTCCTCACTCAGATGGCCAGCCAA
AGGACAGAACTGAGCATGCCGATACAATCGCATGTAATCATGACCCCACAGTCCCAGTCT
GCGGGCAGATGA

Chromosome Location

Locus

12q13.13

External Identifiers

Resource	Link
UniProtKB ID	P17544
UniProtKB Entry Name	ATF7_HUMAN
HGNC ID	HGNC:792

General References

Gaire M, Chatton B, Kedinger C: Isolation and characterization of two novel, closely related ATF cDNA clones from HeLa cells. Nucleic Acids Res. 1990 Jun 25;18(12):3467-73. [Article]
Pescini R, Kaszubska W, Whelan J, DeLamarter JF, Hooft van Huijsduijnen R: ATF-a0, a novel variant of the ATF/CREB transcription factor family, forms a dominant transcription inhibitor in ATF-a heterodimers. J Biol Chem. 1994 Jan 14;269(2):1159-65. [Article]
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Chatton B, Bocco JL, Goetz J, Gaire M, Lutz Y, Kedinger C: Jun and Fos heterodimerize with ATFa, a member of the ATF/CREB family and modulate its transcriptional activity. Oncogene. 1994 Feb;9(2):375-85. [Article]
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Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB00852	Pseudoephedrine	approved	unknown	inhibitor	Details