HLA class I histocompatibility antigen, B-27 alpha chain

Details

Name
HLA class I histocompatibility antigen, B-27 alpha chain
Synonyms
  • HLAB
  • MHC class I antigen B*27
Gene Name
HLA-B
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012842|HLA class I histocompatibility antigen, B-27 alpha chain
MRVTAPRTLLLLLWGAVALTETWAGSHSMRYFHTSVSRPGRGEPRFITVGYVDDTLFVRF
DSDAASPREEPRAPWIEQEGPEYWDRETQICKAKAQTDREDLRTLLRYYNQSEAGSHTLQ
NMYGCDVGPDGRLLRGYHQDAYDGKDYIALNEDLSSWTAADTAAQITQRKWEAARVAEQL
RAYLEGECVEWLRRYLENGKETLQRADPPKTHVTHHPISDHEATLRCWALGFYPAEITLT
WQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP
SSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVSL
TA
Number of residues
362
Molecular Weight
40427.835
Theoretical pI
5.63
GO Classification
Functions
peptide antigen binding
Processes
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of exogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent / antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent / antigen processing and presentation of peptide antigen via MHC class I / cytokine-mediated signaling pathway / defense response / detection of bacterium / immune response / interferon-gamma-mediated signaling pathway / regulation of immune response / type I interferon signaling pathway / viral process
Components
cell surface / early endosome membrane / endoplasmic reticulum / ER to Golgi transport vesicle membrane / extracellular exosome / Golgi apparatus / Golgi membrane / integral component of lumenal side of endoplasmic reticulum membrane / membrane / MHC class I protein complex / phagocytic vesicle membrane / plasma membrane
General Function
Peptide antigen binding
Specific Function
Involved in the presentation of foreign antigens to the immune system.
Pfam Domain Function
Transmembrane Regions
309-332
Cellular Location
Membrane
Chromosome Location
Not Available
Locus
6p21.3
External Identifiers
ResourceLink
UniProtKB IDP01889
UniProtKB Entry Name1B27_HUMAN
GenBank Protein ID896271
GenBank Gene IDL38504
HGNC IDHGNC:4932
General References
  1. Weiss EH, Kuon W, Dorner C, Lang M, Riethmuller G: Organization, sequence and expression of the HLA-B27 gene: a molecular approach to analyze HLA and disease associations. Immunobiology. 1985 Dec;170(5):367-80. [Article]
  2. Szots H, Riethmuller G, Weiss E, Meo T: Complete sequence of HLA-B27 cDNA identified through the characterization of structural markers unique to the HLA-A, -B, and -C allelic series. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1428-32. [Article]
  3. Ezquerra A, Bragado R, Vega MA, Strominger JL, Woody J, Lopez de Castro JA: Primary structure of papain-solubilized human histocompatibility antigen HLA-B27. Biochemistry. 1985 Mar 26;24(7):1733-41. [Article]
  4. Seemann GH, Rein RS, Brown CS, Ploegh HL: Gene conversion-like mechanisms may generate polymorphism in human class I genes. EMBO J. 1986 Mar;5(3):547-52. [Article]
  5. Moses JH, Marsh SG, Arnett KL, Adams EJ, Bodmer JG, Parham P: On the nucleotide sequences of B*2702 and B*2705. Tissue Antigens. 1995 Jul;46(1):50-3. [Article]
  6. Vega MA, Ezquerra A, Rojo S, Aparicio P, Bragado R, Lopez de Castro JA: Structural analysis of an HLA-B27 functional variant: identification of residues that contribute to the specificity of recognition by cytolytic T lymphocytes. Proc Natl Acad Sci U S A. 1985 Nov;82(21):7394-8. [Article]
  7. Choo SY, St John T, Orr HT, Hansen JA: Molecular analysis of the variant alloantigen HLA-B27d (HLA-B*2703) identifies a unique single amino acid substitution. Hum Immunol. 1988 Mar;21(3):209-19. [Article]
  8. Rudwaleit M, Bowness P, Wordsworth P: The nucleotide sequence of HLA-B*2704 reveals a new amino acid substitution in exon 4 which is also present in HLA-B*2706. Immunogenetics. 1996;43(3):160-2. [Article]
  9. Coppin HL, McDevitt HO: Absence of polymorphism between HLA-B27 genomic exon sequences isolated from normal donors and ankylosing spondylitis patients. J Immunol. 1986 Oct 1;137(7):2168-72. [Article]
  10. Vilches C, de Pablo R, Kreisler M: Nucleotide sequence of HLA-B*2706. Immunogenetics. 1994;39(3):219. [Article]
  11. Choo SY, Fan LA, Hansen JA: A novel HLA-B27 allele maps B27 allospecificity to the region around position 70 in the alpha 1 domain. J Immunol. 1991 Jul 1;147(1):174-80. [Article]
  12. Hildebrand WH, Domena JD, Shen SY, Marsh SG, Bunce M, Guttridge MG, Darke C, Parham P: The HLA-B7Qui antigen is encoded by a new subtype of HLA-B27 (B*2708). Tissue Antigens. 1994 Jul;44(1):47-51. [Article]
  13. Del Porto P, D'Amato M, Fiorillo MT, Tuosto L, Piccolella E, Sorrentino R: Identification of a novel HLA-B27 subtype by restriction analysis of a cytotoxic gamma delta T cell clone. J Immunol. 1994 Oct 1;153(7):3093-100. [Article]
  14. Chen R, Jiang X, Sun D, Han G, Wang F, Ye M, Wang L, Zou H: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. J Proteome Res. 2009 Feb;8(2):651-61. doi: 10.1021/pr8008012. [Article]
  15. Bian Y, Song C, Cheng K, Dong M, Wang F, Huang J, Sun D, Wang L, Ye M, Zou H: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. J Proteomics. 2014 Jan 16;96:253-62. doi: 10.1016/j.jprot.2013.11.014. Epub 2013 Nov 22. [Article]
  16. Vaca Jacome AS, Rabilloud T, Schaeffer-Reiss C, Rompais M, Ayoub D, Lane L, Bairoch A, Van Dorsselaer A, Carapito C: N-terminome analysis of the human mitochondrial proteome. Proteomics. 2015 Jul;15(14):2519-24. doi: 10.1002/pmic.201400617. Epub 2015 Jun 8. [Article]
  17. Madden DR, Gorga JC, Strominger JL, Wiley DC: The three-dimensional structure of HLA-B27 at 2.1 A resolution suggests a general mechanism for tight peptide binding to MHC. Cell. 1992 Sep 18;70(6):1035-48. [Article]
  18. Madden DR, Gorga JC, Strominger JL, Wiley DC: The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature. 1991 Sep 26;353(6342):321-5. [Article]
  19. Hulsmeyer M, Hillig RC, Volz A, Ruhl M, Schroder W, Saenger W, Ziegler A, Uchanska-Ziegler B: HLA-B27 subtypes differentially associated with disease exhibit subtle structural alterations. J Biol Chem. 2002 Dec 6;277(49):47844-53. Epub 2002 Sep 18. [Article]
  20. Rognan D, Scapozza L, Folkers G, Daser A: Rational design of nonnatural peptides as high-affinity ligands for the HLA-B*2705 human leukocyte antigen. Proc Natl Acad Sci U S A. 1995 Jan 31;92(3):753-7. [Article]
  21. Varnavidou-Nicolaidou A, Karpasitou K, Georgiou D, Stylianou G, Kokkofitou A, Michalis C, Constantina C, Gregoriadou C, Kyriakides G: HLA-B27 in the Greek Cypriot population: distribution of subtypes in patients with ankylosing spondylitis and other HLA-B27-related diseases. The possible protective role of B*2707. Hum Immunol. 2004 Dec;65(12):1451-4. [Article]
  22. Burkard TR, Planyavsky M, Kaupe I, Breitwieser FP, Burckstummer T, Bennett KL, Superti-Furga G, Colinge J: Initial characterization of the human central proteome. BMC Syst Biol. 2011 Jan 26;5:17. doi: 10.1186/1752-0509-5-17. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04464N-FormylmethionineexperimentalunknownDetails
DB11294Coccidioides immitis spheruleapprovedunknownDetails
DB01048Abacavirapproved, investigationalunknownDetails