Pituitary adenylate cyclase-activating polypeptide
Details
- Name
- Pituitary adenylate cyclase-activating polypeptide
- Synonyms
- PACAP
- Gene Name
- ADCYAP1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017018|Pituitary adenylate cyclase-activating polypeptide MTMCSGARLALLVYGIIMHSSVYSSPAAAGLRFPGIRPEEEAYGEDGNPLPDFDGSEPPG AGSPASAPRAAAAWYRPAGRRDVAHGILNEAYRKVLDQLSAGKHLQSLVARGVGGSLGGG AGDDAEPLSKRHSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNKGRRIAYL
- Number of residues
- 176
- Molecular Weight
- 18835.215
- Theoretical pI
- 10.24
- GO Classification
- Functionsneuropeptide hormone activity / peptide hormone receptor binding / pituitary adenylate cyclase activating polypeptide activity / receptor binding / receptor signaling protein activityProcessesactivation of adenylate cyclase activity / cAMP-mediated signaling / cell-cell signaling / female pregnancy / negative regulation of cell cycle / neuron projection development / neuropeptide signaling pathway / neurotrophin TRK receptor signaling pathway / positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway / positive regulation of chemokine (C-C motif) ligand 5 production / positive regulation of ERK1 and ERK2 cascade / positive regulation of GTPase activity / positive regulation of protein kinase activity / positive regulation of transcription from RNA polymerase II promoter / regulation of G-protein coupled receptor protein signaling pathway / regulation of protein localization / transmembrane receptor protein tyrosine kinase signaling pathwayComponentsextracellular region / intracellular
- General Function
- Receptor signaling protein activity
- Specific Function
- Binding to its receptor activates G proteins and stimulates adenylate cyclase in pituitary cells. Promotes neuron projection development through the RAPGEF2/Rap1/B-Raf/ERK pathway.
- Pfam Domain Function
- Hormone_2 (PF00123)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0017019|Pituitary adenylate cyclase-activating polypeptide (ADCYAP1) ATGACCATGTGTAGCGGAGCGAGGCTGGCCCTGCTGGTCTATGGGATAATCATGCACAGC AGCGTCTACAGCTCACCTGCCGCCGCCGGACTCCGGTTCCCCGGGATCAGGCCAGAGGAA GAGGCGTACGGCGAGGACGGAAACCCGCTGCCAGACTTCGATGGCTCGGAGCCGCCGGGC GCAGGGAGCCCCGCCTCCGCGCCGCGCGCCGCCGCCGCCTGGTACCGCCCGGCCGGGAGA AGAGATGTCGCCCACGGGATCCTTAACGAGGCCTACCGCAAAGTGCTGGACCAGCTGTCC GCCGGGAAGCACCTGCAGTCGCTCGTGGCCCGGGGCGTGGGTGGGAGCCTCGGCGGCGGC GCGGGGGACGACGCGGAGCCGCTCTCCAAGCGCCACTCGGACGGGATCTTCACGGACAGC TACAGCCGCTACCGGAAACAAATGGCTGTCAAGAAATACTTGGCGGCCGTCCTAGGGAAG AGGTATAAACAAAGGGTTAAAAACAAAGGACGCCGAATAGCTTATTTGTAG
- Chromosome Location
- 18
- Locus
- 18p11
- External Identifiers
Resource Link UniProtKB ID P18509 UniProtKB Entry Name PACA_HUMAN GenBank Gene ID S83513 GenAtlas ID ADCYAP1 HGNC ID HGNC:241 - General References
- Ohkubo S, Kimura C, Ogi K, Okazaki K, Hosoya M, Onda H, Miyata A, Arimura A, Fujino M: Primary structure and characterization of the precursor to human pituitary adenylate cyclase activating polypeptide. DNA Cell Biol. 1992 Jan-Feb;11(1):21-30. [Article]
- Hosoya M, Kimura C, Ogi K, Ohkubo S, Miyamoto Y, Kugoh H, Shimizu M, Onda H, Oshimura M, Arimura A, et al.: Structure of the human pituitary adenylate cyclase activating polypeptide (PACAP) gene. Biochim Biophys Acta. 1992 Jan 6;1129(2):199-206. [Article]
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- Kimura C, Ohkubo S, Ogi K, Hosoya M, Itoh Y, Onda H, Miyata A, Jiang L, Dahl RR, Stibbs HH, et al.: A novel peptide which stimulates adenylate cyclase: molecular cloning and characterization of the ovine and human cDNAs. Biochem Biophys Res Commun. 1990 Jan 15;166(1):81-9. [Article]
- Emery AC, Eiden MV, Mustafa T, Eiden LE: Rapgef2 connects GPCR-mediated cAMP signals to ERK activation in neuronal and endocrine cells. Sci Signal. 2013 Jun 25;6(281):ra51. doi: 10.1126/scisignal.2003993. [Article]
- Wray V, Kakoschke C, Nokihara K, Naruse S: Solution structure of pituitary adenylate cyclase activating polypeptide by nuclear magnetic resonance spectroscopy. Biochemistry. 1993 Jun 8;32(22):5832-41. [Article]
- Inooka H, Endo S, Kitada C, Mizuta E, Fujino M: Pituitary adenylate cyclase activating polypeptide (PACAP) with 27 residues. Conformation determined by 1H NMR and CD spectroscopies and distance geometry in 25% methanol solution. Int J Pept Protein Res. 1992 Nov;40(5):456-64. [Article]
- Inooka H, Ohtaki T, Kitahara O, Ikegami T, Endo S, Kitada C, Ogi K, Onda H, Fujino M, Shirakawa M: Conformation of a peptide ligand bound to its G-protein coupled receptor. Nat Struct Biol. 2001 Feb;8(2):161-5. [Article]
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- Gu HF: Genetic variation screening and association studies of the adenylate cyclase activating polypeptide 1 (ADCYAP1) gene in patients with type 2 diabetes. Hum Mutat. 2002 May;19(5):572-3. [Article]