Cytidine deaminase
Details
- Name
- Cytidine deaminase
- Synonyms
- 3.5.4.5
- CDA
- Cytidine aminohydrolase
- Gene Name
- cdd
- Organism
- Bacillus subtilis (strain 168)
- Amino acid sequence
>lcl|BSEQ0011426|Cytidine deaminase MNRQELITEALKARDMAYAPYSKFQVGAALLTKDGKVYRGCNIENAAYSMCNCAERTALF KAVSEGDTEFQMLAVAADTPGPVSPCGACRQVISELCTKDVIVVLTNLQGQIKEMTVEEL LPGAFSSEDLHDERKL
- Number of residues
- 136
- Molecular Weight
- 14853.885
- Theoretical pI
- 4.62
- GO Classification
- Functionscytidine deaminase activity / zinc ion binding
- General Function
- Zinc ion binding
- Specific Function
- This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
- Pfam Domain Function
- dCMP_cyt_deam_1 (PF00383)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0011427|Cytidine deaminase (cdd) ATGAACAGACAAGAATTAATAACAGAAGCTTTAAAAGCGCGTGATATGGCATATGCGCCG TATTCCAAATTCCAAGTAGGAGCCGCTCTTCTTACCAAGGATGGAAAAGTGTACAGAGGC TGCAATATTGAGAACGCGGCATACAGCATGTGCAATTGCGCCGAGCGTACCGCTTTATTT AAAGCTGTTTCTGAAGGGGATACAGAGTTTCAGATGCTGGCCGTTGCGGCTGACACCCCT GGACCAGTATCTCCGTGCGGAGCCTGCCGACAGGTGATTTCTGAGCTTTGCACAAAAGAC GTTATTGTCGTACTGACTAATTTACAAGGACAAATAAAAGAAATGACTGTGGAAGAATTA TTGCCAGGCGCATTTTCATCGGAGGATTTACATGACGAACGAAAGCTTTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P19079 UniProtKB Entry Name CDD_BACSU GenBank Protein ID 606744 GenBank Gene ID U18532 - General References
- Song BH, Neuhard J: Chromosomal location, cloning and nucleotide sequence of the Bacillus subtilis cdd gene encoding cytidine/deoxycytidine deaminase. Mol Gen Genet. 1989 Apr;216(2-3):462-8. [Article]
- Mizuno M, Masuda S, Takemaru K, Hosono S, Sato T, Takeuchi M, Kobayashi Y: Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the Bacillus subtilis genome containing the skin element and many sporulation genes. Microbiology. 1996 Nov;142 ( Pt 11):3103-11. [Article]
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- Johansson E, Mejlhede N, Neuhard J, Larsen S: Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution. Biochemistry. 2002 Feb 26;41(8):2563-70. [Article]
- Johansson E, Neuhard J, Willemoes M, Larsen S: Structural, kinetic, and mutational studies of the zinc ion environment in tetrameric cytidine deaminase. Biochemistry. 2004 May 25;43(20):6020-9. [Article]