Histidine decarboxylase
Details
- Name
- Histidine decarboxylase
- Synonyms
- 4.1.1.22
- HDC
- Gene Name
- HDC
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0000004|Histidine decarboxylase MMEPEEYRERGREMVDYICQYLSTVRERRVTPDVQPGYLRAQLPESAPEDPDSWDSIFGD IERIIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLADAINCLGFTWASSPACTELEMNVM DWLAKMLGLPEHFLHHHPSSQGGGVLQSTVSESTLIALLAARKNKILEMKTSEPDADESC LNARLVAYASDQAHSSVEKAGLISLVKMKFLPVDDNFSLRGEALQKAIEEDKQRGLVPVF VCATLGTTGVCAFDCLSELGPICAREGLWLHIDAAYAGTAFLCPEFRGFLKGIEYADSFT FNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGVATDFMHWQIPLSRRFRSV KLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRNDPSFEIPAKRHLGLVVFRLKGPNCLT ENVLKEIAKAGRLFLIPATIQDKLIIRFTVTSQFTTRDDILRDWNLIRDAATLILSQHCT SQPSPRVGNLISQIRGARAWACGTSLQSVSGAGDDPVQARKIIKQPQRVGAGPMKRENGL HLETLLDPVDDCFSEEAPDATKHKLSSFLFSYLSVQTKKKTVRSLSCNSVPVSAQKPLPT EASVKNGGSSRVRIFSRFPEDMMMLKKSAFKKLIKFYSVPSFPECSSQCGLQLPCCPLQA MV
- Number of residues
- 662
- Molecular Weight
- 74139.825
- Theoretical pI
- 8.06
- GO Classification
- Functionshistidine decarboxylase activity / pyridoxal phosphate bindingProcessescatecholamine biosynthetic process / cellular nitrogen compound metabolic process / histamine biosynthetic process / histidine catabolic process / histidine metabolic process / small molecule metabolic processComponentscytosol
- General Function
- Pyridoxal phosphate binding
- Specific Function
- Catalyzes the biosynthesis of histamine from histidine.
- Pfam Domain Function
- Pyridoxal_deC (PF00282)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0018911|Histidine decarboxylase (HDC) ATGATGGAGCCTGAGGAGTACAGAGAGAGAGGGAGAGAGATGGTGGATTACATCTGCCAG TACCTGAGCACTGTGCGGGAGAGACGTGTGACGCCAGACGTGCAGCCTGGCTACCTGCGA GCCCAGCTGCCTGAGAGTGCTCCTGAGGACCCCGACAGCTGGGACAGCATCTTTGGGGAC ATTGAACGAATCATCATGCCTGGGGTGGTACATTGGCAGAGCCCCCATATGCACGCCTAC TACCCAGCCCTCACCTCTTGGCCCTCCCTGCTAGGAGACATGCTGGCTGATGCCATCAAC TGCTTGGGATTCACCTGGGCATCCAGCCCTGCGTGTACAGAGCTGGAGATGAACGTCATG GACTGGTTGGCAAAAATGCTGGGACTTCCAGAGCACTTCTTGCACCACCACCCCAGCAGC CAGGGCGGAGGCGTCCTGCAGAGCACGGTCAGTGAATCCACTTTGATTGCCCTGCTGGCA GCAAGGAAGAACAAAATCCTGGAAATGAAAACGTCTGAGCCCGATGCTGATGAGTCCTGC CTAAATGCCCGACTCGTGGCCTATGCCTCTGACCAGGCTCACTCCTCTGTGGAAAAGGCT GGTTTGATTTCCCTTGTGAAGATGAAATTTCTGCCTGTGGATGACAACTTCTCACTCCGA GGGGAAGCTCTTCAGAAGGCCATCGAGGAAGACAAGCAGCGGGGCTTGGTGCCCGTCTTT GTCTGTGCAACACTAGGGACCACTGGGGTCTGTGCATTTGACTGCCTGTCAGAGCTGGGC CCCATCTGTGCCCGTGAGGGGCTGTGGCTCCACATCGATGCTGCTTATGCAGGCACTGCC TTCCTGTGCCCCGAGTTCCGGGGGTTTCTGAAGGGGATTGAGTATGCCGACTCCTTCACC TTTAATCCTTCCAAGTGGATGATGGTGCATTTTGACTGTACTGGGTTCTGGGTCAAGGAC AAGTACAAGCTGCAGCAGACCTTCAGTGTGAATCCCATCTACCTCAGGCATGCCAACTCA GGCGTGGCCACCGACTTCATGGGTACTGAAATGGCTAAATATTTTGAATCTCTGGTCAGA AACGACCCTTCCTTTGAAATTCCTGCCAAGAGGCACCTTGGCCTGGTGGTTTTTCGTCTA AAGGGTCCTAATTGTCTCACAGAAAATGTGTTAAAGGAAATAGCTAAAGCTGGCCGTCTC TTCCTCATCCCGGCCACTATCCAGGACAAGTTAATCATCCGTTTCACTGTGACATCCCAG TTTACCACTAGGGATGACATCCTGAGAGACTGGAATCTCATTCGAGATGCTGCCACTCTC ATCCTGAGTCAGCACTGTACTTCCCAACCCAGCCCTCGGGTTGGGAACCTCATCTCCCAA ATCAGGGGTGCCAGAGCCTGGGCCTGTGGAACGTCCCTTCAGTCTGTCAGTGGGGCAGGA GATGATCCAGTCCAGGCCAGGAAGATCATCAAGCAGCCTCAGCGTGTGGGAGCCGGTCCC ATGAAAAGGGAAAATGGCCTCCATCTTGAAACCCTGCTGGACCCAGTTGATGACTGCTTT TCAGAAGAGGCCCCAGATGCCACCAAGCACAAGCTGTCCTCCTTCCTGTTCAGTTACTTG TCTGTGCAGACTAAGAAGAAGACGGTGCGCTCCCTCAGTTGCAACAGTGTGCCAGTGAGT GCTCAGAAGCCACTGCCCACAGAGGCCTCTGTGAAGAATGGGGGCTCCTCCAGGGTCAGA ATCTTTTCCAGGTTTCCAGAAGACATGATGATGCTGAAGAAAAGTGCCTTCAAAAAACTC ATCAAATTCTACAGCGTCCCCAGCTTTCCTGAATGCAGCTCTCAATGTGGACTCCAGCTG CCCTGTTGCCCTCTGCAGGCCATGGTTTAG
- Chromosome Location
- 15
- Locus
- 15q21-q22
- External Identifiers
Resource Link UniProtKB ID P19113 UniProtKB Entry Name DCHS_HUMAN GenBank Protein ID 32109 GenBank Gene ID X54297 GenAtlas ID HDC HGNC ID HGNC:4855 - General References
- Yamauchi K, Sato R, Tanno Y, Ohkawara Y, Maeyama K, Watanabe T, Satoh K, Yoshizawa M, Shibahara S, Takishima T: Nucleotide sequence of the cDNA encoding L-histidine decarboxylase derived from human basophilic leukemia cell line, KU-812-F. Nucleic Acids Res. 1990 Oct 11;18(19):5891. [Article]
- Zahnow CA, Yi HF, McBride OW, Joseph DR: Cloning of the cDNA encoding human histidine decarboxylase from an erythroleukemia cell line and mapping of the gene locus to chromosome 15. DNA Seq. 1991;1(6):395-400. [Article]
- Mamune-Sato R, Yamauchi K, Tanno Y, Ohkawara Y, Ohtsu H, Katayose D, Maeyama K, Watanabe T, Shibahara S, Takishima T: Functional analysis of alternatively spliced transcripts of the human histidine decarboxylase gene and its expression in human tissues and basophilic leukemia cells. Eur J Biochem. 1992 Oct 15;209(2):533-9. [Article]
- Yatsunami K, Ohtsu H, Tsuchikawa M, Higuchi T, Ishibashi K, Shida A, Shima Y, Nakagawa S, Yamauchi K, Yamamoto M, et al.: Structure of the L-histidine decarboxylase gene. J Biol Chem. 1994 Jan 14;269(2):1554-9. [Article]
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- Komori H, Nitta Y, Ueno H, Higuchi Y: Structural study reveals that Ser-354 determines substrate specificity on human histidine decarboxylase. J Biol Chem. 2012 Aug 17;287(34):29175-83. doi: 10.1074/jbc.M112.381897. Epub 2012 Jul 5. [Article]
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