Myeloid cell surface antigen CD33
Details
- Name
- Myeloid cell surface antigen CD33
- Synonyms
- gp67
- Sialic acid-binding Ig-like lectin 3
- Siglec-3
- SIGLEC3
- Gene Name
- CD33
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001344|Myeloid cell surface antigen CD33 MPLLLLLPLLWAGALAMDPNFWLQVQESVTVQEGLCVLVPCTFFHPIPYYDKNSPVHGYW FREGAIISRDSPVATNKLDQEVQEETQGRFRLLGDPSRNNCSLSIVDARRRDNGSYFFRM ERGSTKYSYKSPQLSVHVTDLTHRPKILIPGTLEPGHSKNLTCSVSWACEQGTPPIFSWL SAAPTSLGPRTTHSSVLIITPRPQDHGTNLTCQVKFAGAGVTTERTIQLNVTYVPQNPTT GIFPGDGSGKQETRAGVVHGAIGGAGVTALLALCLCLIFFIVKTHRRKAARTAVGRNDTH PTTGSASPKHQKKSKLHGPTETSSCSGAAPTVEMDEELHYASLNFHGMNPSKDTSTEYSE VRTQ
- Number of residues
- 364
- Molecular Weight
- 39824.885
- Theoretical pI
- 8.48
- GO Classification
- Functionscarbohydrate binding / receptor activityProcessescell adhesion / cell-cell signaling / negative regulation of cell proliferation / regulation of immune response / signal transductionComponentsexternal side of plasma membrane / extracellular exosome / integral component of plasma membrane / plasma membrane
- General Function
- Receptor activity
- Specific Function
- Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
- Pfam Domain Function
- Transmembrane Regions
- 260-282
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0010470|Myeloid cell surface antigen CD33 (CD33) ATGCCGCTGCTGCTACTGCTGCCCCTGCTGTGGGCAGACTTGACCCACAGGCCCAAAATC CTCATCCCTGGCACTCTAGAACCCGGCCACTCCAAAAACCTGACCTGCTCTGTGTCCTGG GCCTGTGAGCAGGGAACACCCCCGATCTTCTCCTGGTTGTCAGCTGCCCCCACCTCCCTG GGCCCCAGGACTACTCACTCCTCGGTGCTCATAATCACCCCACGGCCCCAGGACCACGGC ACCAACCTGACCTGTCAGGTGAAGTTCGCTGGAGCTGGTGTGACTACGGAGAGAACCATC CAGCTCAACGTCACCTATGTTCCACAGAACCCAACAACTGGTATCTTTCCAGGAGATGGC TCAGGGAAACAAGAGACCAGAGCAGGAGTGGTTCATGGGGCCATTGGAGGAGCTGGTGTT ACAGCCCTGCTCGCTCTTTGTCTCTGCCTCATCTTCTTCATAGTGAAGACCCACAGGAGG AAAGCAGCCAGGACAGCAGTGGGCAGGAATGACACCCACCCTACCACAGGGTCAGCCTCC CCGAAACACCAGAAGAAGTCCAAGTTACATGGCCCCACTGAAACCTCAAGCTGTTCAGGT GCCGCCCCTACTGTGGAGATGGATGAGGAGCTGCATTATGCTTCCCTCAACTTTCATGGG ATGAATCCTTCCAAGGACACCTCCACCGAATACTCAGAGGTCAGGACCCAGTGA
- Chromosome Location
- 19
- Locus
- 19q13.3
- External Identifiers
Resource Link UniProtKB ID P20138 UniProtKB Entry Name CD33_HUMAN GenBank Protein ID 180098 GenBank Gene ID M23197 GenAtlas ID CD33 HGNC ID HGNC:1659 - General References
- Simmons D, Seed B: Isolation of a cDNA encoding CD33, a differentiation antigen of myeloid progenitor cells. J Immunol. 1988 Oct 15;141(8):2797-800. [Article]
- Yousef GM, Ordon MH, Foussias G, Diamandis EP: Genomic organization of the siglec gene locus on chromosome 19q13.4 and cloning of two new siglec pseudogenes. Gene. 2002 Mar 20;286(2):259-70. [Article]
- Hernandez-Caselles T, Martinez-Esparza M, Perez-Oliva AB, Quintanilla-Cecconi AM, Garcia-Alonso A, Alvarez-Lopez DM, Garcia-Penarrubia P: A study of CD33 (SIGLEC-3) antigen expression and function on activated human T and NK cells: two isoforms of CD33 are generated by alternative splicing. J Leukoc Biol. 2006 Jan;79(1):46-58. [Article]
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- Freeman SD, Kelm S, Barber EK, Crocker PR: Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules. Blood. 1995 Apr 15;85(8):2005-12. [Article]
- Ulyanova T, Blasioli J, Woodford-Thomas TA, Thomas ML: The sialoadhesin CD33 is a myeloid-specific inhibitory receptor. Eur J Immunol. 1999 Nov;29(11):3440-9. [Article]
- Taylor VC, Buckley CD, Douglas M, Cody AJ, Simmons DL, Freeman SD: The myeloid-specific sialic acid-binding receptor, CD33, associates with the protein-tyrosine phosphatases, SHP-1 and SHP-2. J Biol Chem. 1999 Apr 23;274(17):11505-12. [Article]
- Vitale C, Romagnani C, Puccetti A, Olive D, Costello R, Chiossone L, Pitto A, Bacigalupo A, Moretta L, Mingari MC: Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: engagement of CD33 induces apoptosis of leukemic cells. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5764-9. Epub 2001 Apr 24. [Article]