C4b-binding protein beta chain

Details

Name
C4b-binding protein beta chain
Synonyms
Not Available
Gene Name
C4BPB
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049852|C4b-binding protein beta chain
MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT
LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ
CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV
DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL
ELKKAELKAKLL
Number of residues
252
Molecular Weight
28357.215
Theoretical pI
Not Available
GO Classification
Processes
blood coagulation / complement activation, classical pathway / innate immune response / negative regulation of complement activation, classical pathway / positive regulation of protein catabolic process / regulation of complement activation / regulation of opsonization
Components
extracellular region / extracellular space / other organism cell / plasma membrane
General Function
Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0049853|C4b-binding protein beta chain (C4BPB)
ATGTTTTTTTGGTGTGCGTGCTGTCTTATGGTTGCGTGGCGAGTTTCTGCTTCAGATGCA
GAGCACTGTCCAGAGCTTCCTCCAGTGGACAATAGCATATTTGTCGCAAAGGAGGTGGAA
GGACAGATTCTGGGGACTTACGTTTGTATCAAGGGCTACCACCTGGTAGGAAAGAAGACC
CTTTTTTGCAATGCCTCTAAGGAGTGGGATAACACCACTACTGAGTGCCGCTTGGGCCAC
TGTCCTGATCCTGTGCTGGTGAATGGAGAGTTCAGTTCTTCAGGGCCTGTGAATGTAAGT
GACAAAATCACGTTTATGTGCAATGACCACTACATCCTCAAGGGCAGCAATCGGAGCCAG
TGTCTAGAGGACCACACCTGGGCACCTCCCTTTCCCATCTGCAAAAGTAGGGACTGTGAC
CCTCCTGGGAATCCAGTTCATGGCTATTTTGAAGGAAATAACTTCACCTTAGGATCCACC
ATTAGTTATTACTGTGAAGACAGGTACTACTTAGTGGGCGTGCAGGAGCAGCAATGCGTT
GATGGGGAGTGGAGCAGTGCACTTCCAGTCTGCAAGTTGATCCAGGAAGCTCCCAAACCA
GAGTGTGAGAAGGCACTTCTTGCCTTTCAGGAGAGTAAGAACCTCTGCGAAGCCATGGAG
AACTTTATGCAACAATTAAAGGAAAGTGGCATGACAATGGAGGAGCTAAAATATTCTCTG
GAGCTGAAGAAAGCTGAGTTGAAGGCAAAATTGTTGTAA
Chromosome Location
1
Locus
1q32.1
External Identifiers
ResourceLink
UniProtKB IDP20851
UniProtKB Entry NameC4BPB_HUMAN
HGNC IDHGNC:1328
General References
  1. Hillarp A, Pardo-Manuel F, Ruiz RR, Rodriguez de Cordoba S, Dahlback B: The human C4b-binding protein beta-chain gene. J Biol Chem. 1993 Jul 15;268(20):15017-23. [Article]
  2. Hillarp A, Dahlback B: Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain. Proc Natl Acad Sci U S A. 1990 Feb;87(3):1183-7. [Article]
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  5. Bunkenborg J, Pilch BJ, Podtelejnikov AV, Wisniewski JR: Screening for N-glycosylated proteins by liquid chromatography mass spectrometry. Proteomics. 2004 Feb;4(2):454-65. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01593Zincapproved, investigationalunknownDetails
DB14487Zinc acetateapproved, investigationalunknownDetails
DB14533Zinc chlorideapproved, investigationalunknownmodulatorDetails
DB14548Zinc sulfate, unspecified formapproved, experimentalunknownmodulatorDetails