C4b-binding protein beta chain
Details
- Name
- C4b-binding protein beta chain
- Synonyms
- Not Available
- Gene Name
- C4BPB
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049852|C4b-binding protein beta chain MFFWCACCLMVAWRVSASDAEHCPELPPVDNSIFVAKEVEGQILGTYVCIKGYHLVGKKT LFCNASKEWDNTTTECRLGHCPDPVLVNGEFSSSGPVNVSDKITFMCNDHYILKGSNRSQ CLEDHTWAPPFPICKSRDCDPPGNPVHGYFEGNNFTLGSTISYYCEDRYYLVGVQEQQCV DGEWSSALPVCKLIQEAPKPECEKALLAFQESKNLCEAMENFMQQLKESGMTMEELKYSL ELKKAELKAKLL
- Number of residues
- 252
- Molecular Weight
- 28357.215
- Theoretical pI
- Not Available
- GO Classification
- Processesblood coagulation / complement activation, classical pathway / innate immune response / negative regulation of complement activation, classical pathway / positive regulation of protein catabolic process / regulation of complement activation / regulation of opsonizationComponentsextracellular region / extracellular space / other organism cell / plasma membrane
- General Function
- Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.
- Specific Function
- Not Available
- Pfam Domain Function
- Sushi (PF00084)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0049853|C4b-binding protein beta chain (C4BPB) ATGTTTTTTTGGTGTGCGTGCTGTCTTATGGTTGCGTGGCGAGTTTCTGCTTCAGATGCA GAGCACTGTCCAGAGCTTCCTCCAGTGGACAATAGCATATTTGTCGCAAAGGAGGTGGAA GGACAGATTCTGGGGACTTACGTTTGTATCAAGGGCTACCACCTGGTAGGAAAGAAGACC CTTTTTTGCAATGCCTCTAAGGAGTGGGATAACACCACTACTGAGTGCCGCTTGGGCCAC TGTCCTGATCCTGTGCTGGTGAATGGAGAGTTCAGTTCTTCAGGGCCTGTGAATGTAAGT GACAAAATCACGTTTATGTGCAATGACCACTACATCCTCAAGGGCAGCAATCGGAGCCAG TGTCTAGAGGACCACACCTGGGCACCTCCCTTTCCCATCTGCAAAAGTAGGGACTGTGAC CCTCCTGGGAATCCAGTTCATGGCTATTTTGAAGGAAATAACTTCACCTTAGGATCCACC ATTAGTTATTACTGTGAAGACAGGTACTACTTAGTGGGCGTGCAGGAGCAGCAATGCGTT GATGGGGAGTGGAGCAGTGCACTTCCAGTCTGCAAGTTGATCCAGGAAGCTCCCAAACCA GAGTGTGAGAAGGCACTTCTTGCCTTTCAGGAGAGTAAGAACCTCTGCGAAGCCATGGAG AACTTTATGCAACAATTAAAGGAAAGTGGCATGACAATGGAGGAGCTAAAATATTCTCTG GAGCTGAAGAAAGCTGAGTTGAAGGCAAAATTGTTGTAA
- Chromosome Location
- 1
- Locus
- 1q32.1
- External Identifiers
Resource Link UniProtKB ID P20851 UniProtKB Entry Name C4BPB_HUMAN HGNC ID HGNC:1328 - General References
- Hillarp A, Pardo-Manuel F, Ruiz RR, Rodriguez de Cordoba S, Dahlback B: The human C4b-binding protein beta-chain gene. J Biol Chem. 1993 Jul 15;268(20):15017-23. [Article]
- Hillarp A, Dahlback B: Cloning of cDNA coding for the beta chain of human complement component C4b-binding protein: sequence homology with the alpha chain. Proc Natl Acad Sci U S A. 1990 Feb;87(3):1183-7. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB01593 Zinc approved, investigational unknown Details DB14487 Zinc acetate approved, investigational unknown Details DB14533 Zinc chloride approved, investigational unknown modulator Details DB14548 Zinc sulfate, unspecified form approved, experimental unknown modulator Details