NADPH:adrenodoxin oxidoreductase, mitochondrial
Details
- Name
- NADPH:adrenodoxin oxidoreductase, mitochondrial
- Synonyms
- 1.18.1.6
- ADXR
- AR
- Ferredoxin reductase
- Ferredoxin--NADP(+) reductase
- Gene Name
- FDXR
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009401|NADPH:adrenodoxin oxidoreductase, mitochondrial MASRCWRWWGWSAWPRTRLPPAGSTPSFCHHFSTQEKTPQICVVGSGPAGFYTAQHLLKH PQAHVDIYEKQPVPFGLVRFGVAPDHPEVKNVINTFTQTAHSGRCAFWGNVEVGRDVTVP ELREAYHAVVLSYGAEDHRALEIPGEELPGVCSARAFVGWYNGLPENQELEPDLSCDTAV ILGQGNVALDVARILLTPPEHLERTDITKAALGVLRQSRVKTVWLVGRRGPLQVAFTIKE LREMIQLPGARPILDPVDFLGLQDKIKEVPRPRKRLTELLLRTATEKPGPAEAARQASAS RAWGLRFFRSPQQVLPSPDGRRAAGVRLAVTRLEGVDEATRAVPTGDMEDLPCGLVLSSI GYKSRPVDPSVPFDSKLGVIPNVEGRVMDVPGLYCSGWVKRGPTGVIATTMTDSFLTGQM LLQDLKAGLLPSGPRPGYAAIQALLSSRGVRPVSFSDWEKLDAEEVARGQGTGKPREKLV DPQEMLRLLGH
- Number of residues
- 491
- Molecular Weight
- 53836.36
- Theoretical pI
- Not Available
- GO Classification
- Functionsferredoxin-NADP+ reductase activity / NADPH-adrenodoxin reductase activityProcessesC21-steroid hormone biosynthetic process / cholesterol metabolic process / generation of precursor metabolites and energy / oxidation-reduction process / small molecule metabolic process / steroid biosynthetic process / steroid metabolic process / sterol metabolic process / ubiquinone biosynthetic process / xenobiotic metabolic processComponentscytoplasm / mitochondrial matrix / mitochondrion
- General Function
- Nadph-adrenodoxin reductase activity
- Specific Function
- Serves as the first electron transfer protein in all the mitochondrial P450 systems. Including cholesterol side chain cleavage in all steroidogenic tissues, steroid 11-beta hydroxylation in the adrenal cortex, 25-OH-vitamin D3-24 hydroxylation in the kidney, and sterol C-27 hydroxylation in the liver.
- Pfam Domain Function
- Pyr_redox_2 (PF07992)
- Transmembrane Regions
- Not Available
- Cellular Location
- Mitochondrion matrix
- Gene sequence
>lcl|BSEQ0013135|NADPH:adrenodoxin oxidoreductase, mitochondrial (FDXR) ATGGCTTCGCGCTGCTGGCGCTGGTGGGGCTGGTCGGCGTGGCCTCGGACCCGGCTGCCT CCCGCCGGGAGCACCCCGAGCTTCTGCCACCATTTCTCCACACAGGAGAAGACCCCCCAG ATCTGTGTGGTGGGCAGTGGCCCAGCTGGCTTCTACACGGCCCAACACCTGCTAAAGAGG GTGGAAGCCTTGTGTTCTCAGCCCAGGGTCCTGAACTCTCCTGCTCTGTCTGGGGAAGGG GAGGACCTGGGGGCGTCCCAGCCTCTCTCTCTCGGCCCCACCAGCTGCCACCCTGTTCCC CAGCAGCACCCCCAGGCCCACGTGGACATCTACGAGAAACAGCCTGTGCCCTTTGGCCTG GTGCGCTTTGGTGTGGCGCCTGATCACCCCGAGGTGAAGAATGTCATCAACACATTTACC CAGACGGCCCATTCTGGCCGCTGTGCCTTCTGGGGCAACGTGGAGGTGGGCAGGGACGTG ACGGTGCCGGAGCTGCAGGAGGCCTACCACGCTGTGGTGCTGAGCTACGGGGCAGAGGAC CATCGGGCCCTGGAAATTCCTGGTGAGGAGCTGCCAGGTGTGTGCTCCGCCCGGGCCTTC GTGGGCTGGTACAACGGGCTTCCTGAGAACCAGGAGCTGGAGCCAGACCTGAGCTGTGAC ACAGCCGTGATTCTGGGGCAGGGGAACGTGGCTCTGGACGTGGCCCGCATCCTACTGACC CCACCTGAGCACCTGGAGAGAACGGACATCACGAAGGCAGCCCTGGGTGTACTGAGGCAG AGTCGAGTGAAGACAGTGTGGCTAGTGGGCCGGCGTGGACCCCTGCAAGTGGCCTTCACC ATTAAGGAGCTTCGGGAGATGATTCAGTTACCGGGAGCCCGGCCCATTTTGGATCCTGTG GATTTCTTGGGTCTCCAGGACAAGATCAAGGAGGTCCCCCGCCCGAGGAAGCGGCTGACG GAACTGCTGCTTCGAACGGCCACAGAGAAGCCAGGGCCGGCGGAAGCTGCCCGCCAGGCA TCGGCCTCCCGTGCCTGGGGCCTCCGCTTTTTCCGAAGCCCCCAGCAGGTGCTGCCCTCA CCAGATGGGCGGCGGGCAGCAGGTGTCCGCCTAGCAGTCACTAGACTGGAGGGTGTCGAT GAGGCCACCCGTGCAGTGCCCACGGGAGACATGGAAGACCTCCCTTGTGGGCTGGTGCTC AGCAGCATTGGGTATAAGAGCCGCCCTGTCGACCCAAGCGTGCCCTTTGACTCCAAGCTT GGGGTCATCCCCAATGTGGAGGGCCGGGTTATGGATGTGCCAGGCCTCTACTGCAGCGGC TGGGTGAAGAGAGGACCTACAGGTGTCATAGCCACAACCATGACTGACAGCTTCCTCACC GGCCAGATGCTGCTGCAGGACCTGAAGGCTGGGTTGCTCCCCTCTGGCCCCAGGCCTGGC TACGCAGCCATCCAGGCCCTGCTCAGCAGCCGAGGGGTCCGGCCAGTCTCTTTCTCAGAC TGGGAGAAGCTGGATGCCGAGGAGGTGGCCCGGGGCCAGGGCACGGGGAAGCCCAGGGAG AAGCTGGTGGATCCTCAGGAGATGCTGCGCCTCCTGGGCCACTGA
- Chromosome Location
- 17
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P22570 UniProtKB Entry Name ADRO_HUMAN HGNC ID HGNC:3642 - General References
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- Lin D, Shi YF, Miller WL: Cloning and sequence of the human adrenodoxin reductase gene. Proc Natl Acad Sci U S A. 1990 Nov;87(21):8516-20. [Article]
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