Streptavidin

Details

Name
Streptavidin
Synonyms
  • Streptavidin precursor
Gene Name
Not Available
Organism
Streptomyces avidinii
Amino acid sequence
>lcl|BSEQ0011189|Streptavidin
MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGAD
GALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQY
VGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDA
VQQ
Number of residues
183
Molecular Weight
18833.61
Theoretical pI
8.81
GO Classification
Components
extracellular region
General Function
Not Available
Specific Function
The biological function of streptavidin is not known. Forms a strong non-covalent specific complex with biotin (one molecule of biotin per subunit of streptavidin).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0003308|552 bp
ATGCGCAAGATCGTCGTTGCAGCCATCGCCGTTTCCCTGACCACGGTCTCGATTACGGCC
AGCGCTTCGGCAGACCCCTCCAAGGACTCGAAGGCCCAGGTCTCGGCCGCCGAGGCCGGC
ATCACCGGCACCTGGTACAACCAGCTCGGCTCGACCTTCATCGTGACCGCGGGCGCCGAC
GGCGCCCTGACCGGAACCTACGAGTCGGCCGTCGGCAACGCCGAGAGCCGCTACGTCCTG
ACCGGTCGTTACGACAGCGCCCCGGCCACCGACGGCAGCGGCACCGCCCTCGGTTGGACG
GTGGCCTGGAAGAATAACTACCGCAACGCCCACTCCGCGACCACGTGGAGCGGCCAGTAC
GTCGGCGGCGCCGAGGCGAGGATCAACACCCAGTGGCTGCTGACCTCCGGCACCACCGAG
GCCAACGCCTGGAAGTCCACGCTGGTCGGCCACGACACCTTCACCAAGGTGAAGCCGTCC
GCCGCCTCCATCGACGCGGCGAAGAAGGCCGGCGTCAACAACGGCAACCCGCTCGACGCC
GTTCAGCAGTAG
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP22629
UniProtKB Entry NameSAV_STRAV
GenBank Protein ID46741
GenBank Gene IDX03591
General References
  1. Argarana CE, Kuntz ID, Birken S, Axel R, Cantor CR: Molecular cloning and nucleotide sequence of the streptavidin gene. Nucleic Acids Res. 1986 Feb 25;14(4):1871-82. [Article]
  2. Gitlin G, Bayer EA, Wilchek M: Studies on the biotin-binding site of streptavidin. Tryptophan residues involved in the active site. Biochem J. 1988 Nov 15;256(1):279-82. [Article]
  3. Gitlin G, Bayer EA, Wilchek M: Studies on the biotin-binding sites of avidin and streptavidin. Tyrosine residues are involved in the binding site. Biochem J. 1990 Jul 15;269(2):527-30. [Article]
  4. Alon R, Bayer EA, Wilchek M: Streptavidin contains an RYD sequence which mimics the RGD receptor domain of fibronectin. Biochem Biophys Res Commun. 1990 Aug 16;170(3):1236-41. [Article]
  5. Weber PC, Ohlendorf DH, Wendoloski JJ, Salemme FR: Structural origins of high-affinity biotin binding to streptavidin. Science. 1989 Jan 6;243(4887):85-8. [Article]
  6. Freitag S, Le Trong I, Klumb L, Stayton PS, Stenkamp RE: Structural studies of the streptavidin binding loop. Protein Sci. 1997 Jun;6(6):1157-66. [Article]
  7. Katz BA, Cass RT: In crystals of complexes of streptavidin with peptide ligands containing the HPQ sequence the pKa of the peptide histidine is less than 3.0. J Biol Chem. 1997 May 16;272(20):13220-8. [Article]
  8. Katz BA: Binding of biotin to streptavidin stabilizes intersubunit salt bridges between Asp61 and His87 at low pH. J Mol Biol. 1997 Dec 19;274(5):776-800. [Article]
  9. Freitag S, Le Trong I, Chilkoti A, Klumb LA, Stayton PS, Stenkamp RE: Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex. J Mol Biol. 1998 May 29;279(1):211-21. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01942Formic acidexperimental, investigationalunknownDetails
DB026744-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-ButyricacidexperimentalunknownDetails
DB031126-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Hexanoic AcidexperimentalunknownDetails
DB031396-[5-(2-Oxo-Hexahydro-Thieno[3,4-D]Imidazol-4-Yl)-Pentanoylamino]-Hexanoic AcidexperimentalunknownDetails
DB033532-Iminobiotinexperimental, investigationalunknownDetails
DB03533AcetyleneureaexperimentalunknownDetails
DB03549Biotinyl P-NitroanilineexperimentalunknownDetails
DB046505-[(3AS,4R,6AR)-2-OXOHEXAHYDRO-1H-THIENO[3,4-D]IMIDAZOL-4-YL]PENTANOIC ACIDexperimentalunknownDetails
DB076672-((3',5'-DIMETHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACIDexperimentalunknownDetails
DB04464N-FormylmethionineexperimentalunknownDetails
DB078802-((4'-HYDROXYPHENYL)-AZO)BENZOIC ACIDexperimentalunknownDetails
DB081812-((3'-METHYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACIDexperimentalunknownDetails
DB081962-((3',5'-DIMETHOXY-4'-HYDROXYPHENYL)AZO)BENZOIC ACIDexperimentalunknownDetails
DB082162-((3'-TERTBUTYL-4'-HYDROXYPHENYL)AZO)BENZOIC ACIDexperimentalunknownDetails
DB082522-((4'-HYDROXYNAPHTHYL)-AZO)BENZOIC ACIDexperimentalunknownDetails