cAMP-dependent protein kinase catalytic subunit beta
Details
- Name
- cAMP-dependent protein kinase catalytic subunit beta
- Synonyms
- 2.7.11.11
- PKA C-beta
- Gene Name
- PRKACB
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0009396|cAMP-dependent protein kinase catalytic subunit beta MGNAATAKKGSEVESVKEFLAKAKEDFLKKWENPTQNNAGLEDFERKKTLGTGSFGRVML VKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVRLEYAFKDNSNLYMV MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDHQGY IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVSDIKTHKWFAT TDWIAIYQRKVEAPFIPKFRGSGDTSNFDDYEEEDIRVSITEKCAKEFGEF
- Number of residues
- 351
- Molecular Weight
- 40622.39
- Theoretical pI
- Not Available
- GO Classification
- FunctionsATP binding / cAMP-dependent protein kinase activity / magnesium ion binding / ubiquitin protein ligase bindingProcessesactivation of phospholipase C activity / activation of protein kinase A activity / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / blood coagulation / carbohydrate metabolic process / cellular response to glucagon stimulus / energy reserve metabolic process / epidermal growth factor receptor signaling pathway / fibroblast growth factor receptor signaling pathway / gluconeogenesis / glucose metabolic process / innate immune response / intracellular signal transduction / negative regulation of meiotic cell cycle / negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning / neural tube closure / neurotrophin TRK receptor signaling pathway / protein phosphorylation / regulation of insulin secretion / regulation of protein processing / renal water homeostasis / response to clozapine / signal transduction / small molecule metabolic process / stimulatory C-type lectin receptor signaling pathway / synaptic transmission / transmembrane transport / triglyceride catabolic process / water transportComponentscAMP-dependent protein kinase complex / centrosome / ciliary base / cytosol / extracellular exosome / nucleoplasm / perinuclear region of cytoplasm / plasma membrane
- General Function
- Ubiquitin protein ligase binding
- Specific Function
- Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis.
- Pfam Domain Function
- Pkinase (PF00069)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0021709|cAMP-dependent protein kinase catalytic subunit beta (PRKACB) ATGGGATTGTCACGCAAATCATCAGATGCATCTGCTTGCTCCTCTTCAGAAATATCTGAT TCCTTTGTGAAAGAGTTTCTAGCCAAAGCCAAAGAAGACTTTTTGAAAAAATGGGAGAAT CCAACTCAGAATAATGCCGGACTTGAAGATTTTGAAAGGAAAAAAACCCTTGGAACAGGT TCATTTGGAAGAGTCATGTTGGTAAAACACAAAGCCACTGAACAGTATTATGCCATGAAG ATCTTAGATAAGCAGAAGGTTGTTAAACTGAAGCAAATAGAGCATACTTTGAATGAGAAA AGAATATTACAGGCAGTGAATTTTCCTTTCCTTGTTCGACTGGAGTATGCTTTTAAGGAT AATTCTAATTTATACATGGTTATGGAATATGTCCCTGGGGGTGAAATGTTTTCACATCTA AGAAGAATTGGAAGGTTCAGTGAGCCCCATGCACGGTTCTATGCAGCTCAGATAGTGCTA ACATTCGAGTACCTCCATTCACTAGACCTCATCTACAGAGATCTAAAACCTGAAAATCTC TTAATTGACCATCAAGGCTATATCCAGGTCACAGACTTTGGGTTTGCCAAAAGAGTTAAA GGCAGAACTTGGACATTATGTGGAACTCCAGAGTATTTGGCTCCAGAAATAATTCTCAGC AAGGGCTACAATAAGGCAGTGGATTGGTGGGCATTAGGAGTGCTAATCTATGAAATGGCA GCTGGCTATCCCCCATTCTTTGCAGACCAACCAATTCAGATTTATGAAAAGATTGTTTCT GGAAAGGTCCGATTCCCATCCCACTTCAGTTCAGATCTCAAGGACCTTCTACGGAACCTG CTGCAGGTGGATTTGACCAAGAGATTTGGAAATCTAAAGAATGGTGTCAGTGATATAAAA ACTCACAAGTGGTTTGCCACGACAGATTGGATTGCTATTTACCAGAGGAAGGTTGAAGCT CCATTCATACCAAAGTTTAGAGGCTCTGGAGATACCAGCAACTTTGATGACTATGAAGAA GAAGATATCCGTGTCTCTATAACAGAAAAATGTGCAAAAGAATTTGGTGAATTTTAA
- Chromosome Location
- 1
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P22694 UniProtKB Entry Name KAPCB_HUMAN HGNC ID HGNC:9381 - General References
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