AMP deaminase 1
Details
- Name
- AMP deaminase 1
- Synonyms
- 3.5.4.6
- AMP deaminase isoform M
- Myoadenylate deaminase
- Gene Name
- AMPD1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0036996|AMP deaminase 1 MNVRIFYSVSQSPHSLLSLLFYCAILESRISATMPLFKLPAEEKQIDDAMRNFAEKVFAS EVKDEGGRQEISPFDVDEICPISHHEMQAHIFHLETLSTSTEARRKKRFQGRKTVNLSIP LSETSSTKLSHIDEYISSSPTYQTVPDFQRVQITGDYASGVTVEDFEIVCKGLYRALCIR EKYMQKSFQRFPKTPSKYLRNIDGEAWVANESFYPVFTPPVKKGEDPFRTDNLPENLGYH LKMKDGVVYVYPNEAAVSKDEPKPLPYPNLDTFLDDMNFLLALIAQGPVKTYTHRRLKFL SSKFQVHQMLNEMDELKELKNNPHRDFYNCRKVDTHIHAAACMNQKHLLRFIKKSYQIDA DRVVYSTKEKNLTLKELFAKLKMHPYDLTVDSLDVHAGRQTFQRFDKFNDKYNPVGASEL RDLYLKTDNYINGEYFATIIKEVGADLVEAKYQHAEPRLSIYGRSPDEWSKLSSWFVCNR IHCPNMTWMIQVPRIYDVFRSKNFLPHFGKMLENIFMPVFEATINPQADPELSVFLKHIT GFDSVDDESKHSGHMFSSKSPKPQEWTLEKNPSYTYYAYYMYANIMVLNSLRKERGMNTF LFRPHCGEAGALTHLMTAFMIADDISHGLNLKKSPVLQYLFFLAQIPIAMSPLSNNSLFL EYAKNPFLDFLQKGLMISLSTDDPMQFHFTKEPLMEEYAIAAQVFKLSTCDMCEVARNSV LQCGISHEEKVKFLGDNYLEEGPAGNDIRRTNVAQIRMAYRYETWCYELNLIAEGLKSTE
- Number of residues
- 780
- Molecular Weight
- 90218.455
- Theoretical pI
- 6.89
- GO Classification
- FunctionsAMP deaminase activity / metal ion bindingProcessesIMP salvage / nucleobase-containing small molecule metabolic process / purine nucleobase metabolic process / purine-containing compound salvage / response to organic substance / small molecule metabolic processComponentscytosol
- General Function
- Metal ion binding
- Specific Function
- AMP deaminase plays a critical role in energy metabolism.
- Pfam Domain Function
- A_deaminase (PF00962)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasmic
- Gene sequence
>lcl|BSEQ0016069|AMP deaminase 1 (AMPD1) ATGAATGTCAGGATATTTTATAGTGTCAGTCAGTCACCCCACAGTCTCCTCTCTCTTCTT TTCTACTGTGCTATCCTAGAATCAAGGATTTCAGCAACAATGCCTCTGTTCAAACTCCCA GCTGAAGAGAAACAAATTGATGATGCAATGCGCAACTTTGCTGAAAAAGTGTTTGCCTCT GAAGTCAAAGATGAAGGAGGTCGTCAGGAGATTTCCCCCTTTGATGTGGATGAGATCTGT CCGATTTCTCATCATGAGATGCAAGCACACATATTCCATCTGGAGACTCTGTCCACCTCC ACAGAAGCCAGGAGAAAAAAGCGTTTCCAAGGACGGAAGACTGTTAATTTGTCCATTCCA CTAAGTGAAACATCTTCCACCAAACTGTCCCACATTGATGAATACATTTCCTCATCTCCA ACCTACCAGACCGTGCCTGATTTTCAGAGAGTGCAGATTACTGGTGACTATGCCTCTGGG GTTACAGTTGAAGATTTTGAAATTGTTTGCAAAGGTCTGTATCGGGCACTATGCATACGT GAGAAATACATGCAGAAGTCGTTTCAGAGGTTCCCTAAAACCCCTTCCAAATACTTGCGG AACATTGATGGTGAGGCTTGGGTAGCAAATGAGAGCTTCTATCCAGTCTTTACTCCTCCT GTGAAGAAGGGAGAGGACCCCTTCCGAACAGACAACCTTCCTGAAAACCTGGGCTATCAC CTCAAAATGAAGGACGGTGTAGTTTACGTCTATCCTAATGAAGCAGCAGTCAGCAAAGAT GAGCCTAAGCCACTTCCTTACCCAAATCTGGACACCTTCTTAGACGATATGAATTTTTTA CTTGCTTTAATTGCTCAAGGACCTGTTAAGACCTATACCCACCGGCGCCTGAAGTTCCTC TCCTCCAAGTTCCAGGTCCATCAGATGCTTAACGAGATGGACGAGTTAAAGGAGCTGAAA AACAACCCCCACCGAGATTTTTATAACTGCAGGAAGGTGGACACCCATATCCATGCAGCC GCTTGCATGAACCAGAAACATCTGCTGCGTTTTATTAAGAAATCTTACCAAATTGATGCT GACAGAGTGGTCTATAGCACCAAAGAGAAGAATCTGACCCTAAAGGAACTTTTTGCTAAA TTAAAAATGCATCCTTATGACCTGACTGTTGATTCTCTGGATGTTCATGCTGGACGCCAG ACCTTCCAGCGTTTTGATAAGTTCAATGACAAATATAATCCTGTAGGAGCAAGTGAGCTA CGGGACCTCTACTTGAAGACAGACAATTACATTAATGGGGAATATTTTGCCACTATCATC AAGGAGGTAGGTGCGGACCTGGTGGAGGCCAAGTACCAGCATGCTGAGCCCCGCCTGTCC ATCTATGGCCGCAGTCCTGATGAGTGGAGCAAACTCTCCTCCTGGTTCGTCTGCAATCGC ATCCACTGCCCCAACATGACATGGATGATCCAGGTTCCCAGGATCTATGATGTGTTCCGT TCCAAGAATTTCCTTCCACATTTTGGAAAAATGCTGGAGAATATTTTCATGCCAGTGTTT GAGGCCACCATCAACCCCCAGGCTGACCCAGAACTCAGTGTCTTCCTCAAGCATATCACT GGCTTTGACAGTGTGGATGATGAGTCCAAACACAGTGGCCACATGTTCTCCTCCAAGAGT CCCAAGCCCCAGGAGTGGACATTGGAAAAGAATCCATCTTACACTTACTATGCCTACTAC ATGTATGCAAACATCATGGTGCTCAACAGCCTGAGAAAGGAACGAGGCATGAATACGTTT CTGTTCCGACCTCACTGTGGAGAAGCTGGAGCCCTCACCCATCTCATGACAGCATTCATG ATAGCAGATGATATCTCTCATGGCCTAAATTTAAAAAAGAGTCCCGTGCTACAGTACTTG TTTTTCTTAGCCCAAATTCCCATCGCCATGTCACCACTAAGTAACAATAGCCTATTTCTA GAGTATGCCAAAAATCCTTTTTTGGATTTCCTTCAGAAAGGGCTAATGATCTCACTGTCT ACAGATGACCCAATGCAATTCCACTTTACCAAGGAGCCCCTAATGGAAGAATATGCTATT GCTGCACAAGTCTTCAAGCTGAGCACCTGTGATATGTGCGAAGTGGCAAGGAACAGTGTC TTGCAGTGTGGAATTTCTCATGAGGAGAAAGTAAAGTTTCTGGGCGACAATTACCTTGAG GAAGGCCCTGCTGGAAATGATATCCGGAGGACAAATGTAGCCCAAATCCGCATGGCCTAT CGCTATGAAACCTGGTGTTATGAACTCAATTTAATTGCTGAGGGTCTTAAATCAACAGAA TAA
- Chromosome Location
- 1
- Locus
- 1p13
- External Identifiers
Resource Link UniProtKB ID P23109 UniProtKB Entry Name AMPD1_HUMAN GenBank Protein ID 10864686 GenBank Gene ID M37931 GenAtlas ID AMPD1 HGNC ID HGNC:468 - General References
- Sabina RL, Morisaki T, Clarke P, Eddy R, Shows TB, Morton CC, Holmes EW: Characterization of the human and rat myoadenylate deaminase genes. J Biol Chem. 1990 Jun 5;265(16):9423-33. [Article]
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- Morisaki T, Gross M, Morisaki H, Pongratz D, Zollner N, Holmes EW: Molecular basis of AMP deaminase deficiency in skeletal muscle. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6457-61. [Article]
- Morisaki H, Higuchi I, Abe M, Osame M, Morisaki T: First missense mutations (R388W and R425H) of AMPD1 accompanied with myopathy found in a Japanese patient. Hum Mutat. 2000 Dec;16(6):467-72. [Article]
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