Brain-derived neurotrophic factor

Details

Name
Brain-derived neurotrophic factor
Synonyms
  • Abrineurin
  • BDNF
Gene Name
BDNF
Organism
Humans
Amino acid sequence
>lcl|BSEQ0006623|Brain-derived neurotrophic factor
MTILFLTMVISYFGCMKAAPMKEANIRGQGGLAYPGVRTHGTLESVNGPKAGSRGLTSLA
DTFEHVIEELLDEDQKVRPNEENNKDADLYTSRVMLSSQVPLEPPLLFLLEEYKNYLDAA
NMSMRVRRHSDPARRGELSVCDSISEWVTAADKKTAVDMSGGTVTVLEKVPVSKGQLKQY
FYETKCNPMGYTKEGCRGIDKRHWNSQCRTTQSYVRALTMDSKKRIGWRFIRIDTSCVCT
LTIKRGR
Number of residues
247
Molecular Weight
27817.72
Theoretical pI
9.01
GO Classification
Functions
growth factor activity / neurotrophin TRKB receptor binding
Processes
axon extension / axon guidance / axon target recognition / behavioral fear response / brain-derived neurotrophic factor receptor signaling pathway / cell-cell signaling / cellular response to nerve growth factor stimulus / cellular response to norepinephrine stimulus / cellular response to tumor necrosis factor / chronic inflammatory response / collateral sprouting / dendrite development / dendrite extension / excitatory postsynaptic potential / feeding behavior / gamma-aminobutyric acid signaling pathway / glutamate secretion / inhibitory postsynaptic potential / inner ear development / learning / mechanoreceptor differentiation / mitochondrial electron transport, NADH to ubiquinone / negative regulation of neuroblast proliferation / negative regulation of neuron apoptotic process / negative regulation of striated muscle tissue development / negative regulation of synaptic transmission, GABAergic / nerve development / nervous system development / neuron projection morphogenesis / neuron recognition / positive regulation of brain-derived neurotrophic factor receptor signaling pathway / positive regulation of collateral sprouting / positive regulation of glucocorticoid receptor signaling pathway / positive regulation of long-term neuronal synaptic plasticity / positive regulation of peptidyl-serine phosphorylation / positive regulation of sequence-specific DNA binding transcription factor activity / positive regulation of synapse assembly / regulation of axon extension / regulation of neuron differentiation / regulation of retinal cell programmed cell death / regulation of short-term neuronal synaptic plasticity / response to activity / response to anesthetic / response to auditory stimulus / response to electrical stimulus / response to fluoxetine / response to food / response to hormone / response to hyperoxia / response to hypoxia / response to L-glutamate / response to light intensity / response to potassium ion / response to vitamin A / synapse assembly / taste bud development / transmembrane receptor protein tyrosine kinase signaling pathway / ureteric bud development
Components
cytoplasm / cytoplasmic membrane-bounded vesicle / dendrite / extracellular space / mitochondrial crista / perikaryon / perinuclear region of cytoplasm / synaptic vesicle / terminal bouton
General Function
Neurotrophin trkb receptor binding
Specific Function
During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0021859|Brain-derived neurotrophic factor (BDNF)
ATGACCATCCTTTTCCTTACTATGGTTATTTCATACTTTGGTTGCATGAAGGCTGCCCCC
ATGAAAGAAGCAAACATCCGAGGACAAGGTGGCTTGGCCTACCCAGGTGTGCGGACCCAT
GGGACTCTGGAGAGCGTGAATGGGCCCAAGGCAGGTTCAAGAGGCTTGACATCATTGGCT
GACACTTTCGAACACGTGATAGAAGAGCTGTTGGATGAGGACCAGAAAGTTCGGCCCAAT
GAAGAAAACAATAAGGACGCAGACTTGTACACGTCCAGGGTGATGCTCAGTAGTCAAGTG
CCTTTGGAGCCTCCTCTTCTCTTTCTGCTGGAGGAATACAAAAATTACCTAGATGCTGCA
AACATGTCCATGAGGGTCCGGCGCCACTCTGACCCTGCCCGCCGAGGGGAGCTGAGCGTG
TGTGACAGTATTAGTGAGTGGGTAACGGCGGCAGACAAAAAGACTGCAGTGGACATGTCG
GGCGGGACGGTCACAGTCCTTGAAAAGGTCCCTGTATCAAAAGGCCAACTGAAGCAATAC
TTCTACGAGACCAAGTGCAATCCCATGGGTTACACAAAAGAAGGCTGCAGGGGCATAGAC
AAAAGGCATTGGAACTCCCAGTGCCGAACTACCCAGTCGTACGTGCGGGCCCTTACCATG
GATAGCAAAAAGAGAATTGGCTGGCGATTCATAAGGATAGACACTTCTTGTGTATGTACA
TTGACCATTAAAAGGGGAAGATAG
Chromosome Location
11
Locus
11p13
External Identifiers
ResourceLink
UniProtKB IDP23560
UniProtKB Entry NameBDNF_HUMAN
GenBank Gene IDM37762
GenAtlas IDBDNF
HGNC IDHGNC:1033
General References
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  3. Shintani A, Ono Y, Kaisho Y, Igarashi K: Characterization of the 5'-flanking region of the human brain-derived neurotrophic factor gene. Biochem Biophys Res Commun. 1992 Jan 15;182(1):325-32. [Article]
  4. Liu QR, Walther D, Drgon T, Polesskaya O, Lesnick TG, Strain KJ, de Andrade M, Bower JH, Maraganore DM, Uhl GR: Human brain derived neurotrophic factor (BDNF) genes, splicing patterns, and assessments of associations with substance abuse and Parkinson's Disease. Am J Med Genet B Neuropsychiatr Genet. 2005 Apr 5;134B(1):93-103. [Article]
  5. Pruunsild P, Kazantseva A, Aid T, Palm K, Timmusk T: Dissecting the human BDNF locus: bidirectional transcription, complex splicing, and multiple promoters. Genomics. 2007 Sep;90(3):397-406. Epub 2007 Jul 12. [Article]
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  9. Hallbook F, Ibanez CF, Persson H: Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron. 1991 May;6(5):845-58. [Article]
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  13. Ribases M, Gratacos M, Fernandez-Aranda F, Bellodi L, Boni C, Anderluh M, Cavallini MC, Cellini E, Di Bella D, Erzegovesi S, Foulon C, Gabrovsek M, Gorwood P, Hebebrand J, Hinney A, Holliday J, Hu X, Karwautz A, Kipman A, Komel R, Nacmias B, Remschmidt H, Ricca V, Sorbi S, Wagner G, Treasure J, Collier DA, Estivill X: Association of BDNF with anorexia, bulimia and age of onset of weight loss in six European populations. Hum Mol Genet. 2004 Jun 15;13(12):1205-12. Epub 2004 Apr 28. [Article]
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  15. Robinson RC, Radziejewski C, Stuart DI, Jones EY: Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. Biochemistry. 1995 Apr 4;34(13):4139-46. [Article]
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  18. Hall D, Dhilla A, Charalambous A, Gogos JA, Karayiorgou M: Sequence variants of the brain-derived neurotrophic factor (BDNF) gene are strongly associated with obsessive-compulsive disorder. Am J Hum Genet. 2003 Aug;73(2):370-6. Epub 2003 Jun 27. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05047CX-717illicit, investigationalunknownDetails
DB09301Chondroitin sulfateapproved, investigational, nutraceuticalunknownDetails
DB09130Copperapproved, investigationalunknowncofactorDetails
DB11823Esketamineapproved, investigationalunknownagonistDetails