Sodium-dependent noradrenaline transporter

Details

Name
Sodium-dependent noradrenaline transporter
Synonyms
  • NAT1
  • NET
  • NET1
  • Norepinephrine transporter
  • SLC6A5
  • Solute carrier family 6 member 2
Gene Name
SLC6A2
Organism
Human
Amino acid sequence
>lcl|BSEQ0000970|Sodium-dependent noradrenaline transporter
MLLARMNPQVQPENNGADTGPEQPLRARKTAELLVVKERNGVQCLLAPRDGDAQPRETWG
KKIDFLLSVVGFAVDLANVWRFPYLCYKNGGGAFLIPYTLFLIIAGMPLFYMELALGQYN
REGAATVWKICPFFKGVGYAVILIALYVGFYYNVIIAWSLYYLFSSFTLNLPWTDCGHTW
NSPNCTDPKLLNGSVLGNHTKYSKYKFTPAAEFYERGVLHLHESSGIHDIGLPQWQLLLC
LMVVVIVLYFSLWKGVKTSGKVVWITATLPYFVLFVLLVHGVTLPGASNGINAYLHIDFY
RLKEATVWIDAATQIFFSLGAGFGVLIAFASYNKFDNNCYRDALLTSSINCITSFVSGFA
IFSILGYMAHEHKVNIEDVATEGAGLVFILYPEAISTLSGSTFWAVVFFVMLLALGLDSS
MGGMEAVITGLADDFQVLKRHRKLFTFGVTFSTFLLALFCITKGGIYVLTLLDTFAAGTS
ILFAVLMEAIGVSWFYGVDRFSNDIQQMMGFRPGLYWRLCWKFVSPAFLLFVVVVSIINF
KPLTYDDYIFPPWANWVGWGIALSSMVLVPIYVIYKFLSTQGSLWERLAYGITPENEHHL
VAQRDIRQFQLQHWLAI
Number of residues
617
Molecular Weight
69331.42
Theoretical pI
7.53
GO Classification
Functions
monoamine transmembrane transporter activity / norepinephrine
Processes
transport / norepinephrine transport / synaptic transmission / transmembrane transport / monoamine transport / response to pain
Components
membrane / plasma membrane / integral component of plasma membrane / neuron projection
General Function
Norepinephrine:sodium symporter activity
Specific Function
Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals.
Pfam Domain Function
Transmembrane Regions
65-85 93-112 136-156 235-253 262-279 315-332 344-365 398-417 444-462 478-498 519-538 557-575
Cellular Location
Membrane
Gene sequence
>lcl|BSEQ0010343|Sodium-dependent noradrenaline transporter (SLC6A2)
ATGCTTCTGGCGCGGATGAACCCGCAGGTGCAGCCCGAGAACAACGGGGCGGACACGGGT
CCAGAGCAGCCCCTTCGGGCGCGCAAAACTGCGGAGCTGCTGGTGGTGAAGGAGCGCAAC
GGCGTCCAGTGCCTGCTGGCGCCCCGCGACGGCGACGCGCAGCCCCGGGAGACCTGGGGC
AAGAAGATCGACTTCCTGCTGTCCGTAGTCGGCTTCGCAGTGGACCTGGCCAACGTGTGG
CGCTTCCCCTACCTCTGCTACAAGAACGGCGGCGGTGCCTTCTTGATCCCGTACACACTG
TTCCTTATCATCGCGGGGATGCCCCTGTTCTACATGGAGCTGGCTCTGGGACAGTACAAC
CGGGAGGGGGCTGCCACCGTTTGGAAAATCTGCCCATTCTTCAAAGGCGTTGGCTATGCT
GTCATCCTGATCGCCCTGTACGTTGGCTTCTACTACAACGTCATCATCGCCTGGTCACTC
TACTACCTCTTCTCCTCCTTCACCCTCAACCTGCCCTGGACCGACTGTGGCCACACCTGG
AACAGCCCCAACTGTACCGACCCCAAGCTCCTCAATGGCTCCGTGCTTGGCAACCACACC
AAGTACTCCAAGTACAAGTTCACGCCGGCAGCCGAGTTTTATGAGCGTGGTGTCCTGCAC
CTTCACGAGAGCAGCGGGATTCATGACATCGGCCTGCCCCAGTGGCAGCTCTTGCTCTGT
CTGATGGTCGTCGTCATCGTCTTGTATTTTAGCCTCTGGAAAGGGGTGAAGACATCAGGA
AAGGTGGTGTGGATCACAGCCACGCTGCCTTACTTCGTGCTGTTCGTGCTCCTGGTCCAT
GGCGTCACGCTGCCCGGAGCCTCCAATGGCATCAATGCCTACCTGCACATCGACTTCTAC
CGCTTGAAAGAGGCCACGGTATGGATTGATGCCGCAACTCAGATATTTTTTTCCTTGGGG
GCTGGATTTGGAGTATTGATTGCATTTGCCAGTTACAACAAATTTGACAACAACTGTTAC
AGGGATGCCCTGCTGACCAGCAGCATCAACTGTATCACCAGCTTCGTCTCTGGGTTCGCC
ATCTTCTCCATCCTTGGTTACATGGCCCATGAACACAAGGTCAACATTGAGGATGTGGCC
ACAGAAGGAGCTGGCCTAGTGTTCATCCTGTATCCAGAGGCCATTTCTACCCTGTCTGGA
TCTACATTCTGGGCTGTTGTGTTTTTCGTCATGCTCCTGGCGCTGGGCCTTGACAGCTCA
ATGGGAGGCATGGAGGCTGTCATCACGGGCCTGGCAGATGACTTCCAGGTCCTGAAGCGA
CACCGGAAACTCTTCACATTTGGCGTCACCTTCAGCACTTTCCTTCTCGCCCTGTTCTGC
ATAACCAAGGGTGGAATTTACGTCTTGACCCTCCTGGACACCTTTGCTGCGGGCACCTCC
ATCCTTTTTGCTGTCCTCATGGAAGCCATCGGAGTTTCCTGGTTTTATGGAGTGGACAGG
TTCAGCAACGACATCCAGCAGATGATGGGGTTCAGGCCGGGTCTATACTGGAGACTGTGC
TGGAAGTTCGTCAGTCCTGCCTTCCTCCTGTTCGTGGTTGTGGTCAGCATCATCAACTTC
AAGCCACTCACCTACGACGACTACATCTTCCCGCCCTGGGCCAACTGGGTGGGGTGGGGC
ATCGCCCTGTCCTCCATGGTCCTGGTGCCCATCTACGTCATCTATAAGTTCCTCAGCACG
CAGGGCTCTCTTTGGGAGAGACTGGCCTATGGCATCACGCCAGAGAACGAGCACCACCTG
GTGGCTCAGAGGGACATCAGACAGTTCCAGTTGCAACACTGGCTGGCCATCTGA
Chromosome Location
16
Locus
16q12.2
External Identifiers
ResourceLink
UniProtKB IDP23975
UniProtKB Entry NameSC6A2_HUMAN
GenBank Protein ID189258
GenBank Gene IDM65105
GenAtlas IDSLC6A2
HGNC IDHGNC:11048
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00191Phentermineapproved, illicityesinhibitorDetails
DB00234Reboxetineapproved, investigationalyesinhibitorDetails
DB00289AtomoxetineapprovedyesDetails
DB00344ProtriptylineapprovedyesinhibitorDetails
DB00458ImipramineapprovedyesinhibitorDetails
DB00579Mazindolapproved, investigationalyesinhibitorDetails
DB00830Phenmetrazineapproved, illicityesinhibitorDetails
DB00937Diethylpropionapproved, illicityesinhibitorDetails
DB00193Tramadolapproved, investigationalyesinhibitorDetails
DB00226Guanadrelapprovedyespartial agonistDetails
DB00285VenlafaxineapprovedyesinhibitorDetails
DB00321AmitriptylineapprovedyesinhibitorDetails
DB00422Methylphenidateapproved, investigationalunknowninhibitorDetails
DB00476DuloxetineapprovedyesinhibitorDetails
DB00540NortriptylineapprovedyesinhibitorDetails
DB00543AmoxapineapprovedunknowninhibitorDetails
DB00726TrimipramineapprovedyesinhibitorDetails
DB00907Cocaineapproved, illicityesinhibitorDetails
DB00934Maprotilineapproved, investigationalyesinhibitorDetails
DB01105Sibutramineapproved, illicit, investigational, withdrawnyesinhibitorDetails
DB01142Doxepinapproved, investigationalyesinhibitorDetails
DB01149Nefazodoneapproved, withdrawnyesinhibitorDetails
DB01151Desipramineapproved, investigationalyesinhibitorDetails
DB01156BupropionapprovedyesinhibitorDetails
DB01170GuanethidineapprovedyesinducerDetails
DB01242Clomipramineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00715Paroxetineapproved, investigationalunknowninhibitorDetails
DB04836Amineptineillicit, withdrawnunknownDetails
DB04840Debrisoquinapproved, investigationalyesinducerDetails
DB00696ErgotamineapprovedunknowninhibitorDetails
DB04889BicifadineinvestigationalunknownDetails
DB04896Milnacipranapproved, investigationalyesinhibitorDetails
DB05012XEN2174investigationalunknownDetails
DB05688CRx-119investigationalunknownDetails
DB12305DasotralineinvestigationalunknownDetails
DB06156TesofensineinvestigationalunknownDetails
DB05642DDP-225investigationalunknownDetails
DB06204TapentadolapprovedyesinhibitorDetails
DB06333TrodusquemineinvestigationalunknownDetails
DB04821NomifensinewithdrawnunknownDetails
DB01175Escitalopramapproved, investigationalunknowninhibitorDetails
DB01114ChlorphenamineapprovedunknowninhibitorDetails
DB01381Ginkgo bilobaapproved, investigational, nutraceuticalunknowninhibitorDetails
DB01173OrphenadrineapprovedyesinhibitorDetails
DB06700Desvenlafaxineapproved, investigationalyesinhibitorDetails
DB06148Mianserinapproved, investigationalunknowninhibitorDetails
DB06701Dexmethylphenidateapproved, investigationalyesinhibitorDetails
DB00852PseudoephedrineapprovedyesinhibitorDetails
DB01576Dextroamphetamineapproved, illicityesnegative modulatorDetails
DB01579Phendimetrazineapproved, illicityesnegative modulatorDetails
DB01363Ephedraapproved, nutraceutical, withdrawnyesnegative modulatorDetails
DB01442MMDAexperimental, illicityesnegative modulatorDetails
DB01577Methamphetamineapproved, illicityesnegative modulatorDetails
DB01454Midomafetamineexperimental, illicit, investigationalyesnegative modulatorDetails
DB01364Ephedrineapprovedunknowninverse agonistDetails
DB00368NorepinephrineapprovedunknownsubstrateDetails
DB06262Droxidopaapproved, investigationalunknownsubstrateDetails
DB01454Midomafetamineexperimental, illicit, investigationalunknownDetails
DB06704Iobenguaneapproved, investigationalyessubstrateDetails
DB00215CitalopramapprovedunknownsubstrateinhibitorDetails
DB08918Levomilnacipranapproved, investigationalyesinhibitorDetails
DB00408LoxapineapprovedunknownbinderDetails
DB00370MirtazapineapprovedunknownbinderDetails
DB00182Amphetamineapproved, illicit, investigationalunknownstimulatorDetails
DB00514DextromethorphanapprovedunknownDetails
DB00988DopamineapprovedunknownDetails
DB00454PethidineapprovedunknownDetails
DB01221Ketamineapproved, vet_approvedunknownDetails
DB09546Iobenguane sulfate I-123approved, investigationalnosubstrateDetails
DB09167DosulepinapprovedyesinhibitorDetails
DB09185Viloxazineapproved, investigational, withdrawnyesinhibitorDetails
DB09194EtoperidonewithdrawnunknowninhibitorDetails
DB09225Zotepineapproved, investigational, withdrawnyesantagonistDetails
DB09363Rauwolfia serpentina rootinvestigationalunknowninhibitorDetails