Dr hemagglutinin structural subunit
Details
- Name
- Dr hemagglutinin structural subunit
- Synonyms
- Dr hemagglutinin structural subunit precursor
- Gene Name
- draA
- Organism
- Escherichia coli
- Amino acid sequence
>lcl|BSEQ0011094|Dr hemagglutinin structural subunit MKKLAIMAAASMVFAVSSAHAGFTPSGTTGTTKLTVTEECQVRVGDLTVAKTRGQLTDAA PIGPVTVQALGCDARQVALKADTDNFEQGKFFLISDNNRDKLYVNIRPTDNSAWTTDNGV FYKNDVGSWGGIIGIYVDGQQTNTPPGNYTLTLTGGYWAK
- Number of residues
- 160
- Molecular Weight
- 17058.095
- Theoretical pI
- 7.25
- GO Classification
- Componentspilus
- General Function
- Not Available
- Specific Function
- Hemagglutinins of uropathogenic E.coli mediate adherence to the upper urinary tract. These adhesins bind to the Dr blood group antigen and also agglutinate human erythrocytes in the presence of D-mannose (mannose-resistant hemagglutination (MRHA)).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Fimbrium
- Gene sequence
>lcl|BSEQ0003065|483 bp ATGAAAAAATTAGCGATCATGGCCGCGGCCAGCATGGTGTTCGCCGTGAGCTCCGCGCAT GCTGGGTTCACCCCGAGTGGCACCACCGGCACCACCAAACTCACAGTTACCGAAGAGTGC CAGGTACGGGTTGGTGACCTGACCGTGGCTAAGACTCGTGGCCAACTGACGGACGCAGCA CCAATAGGGCCGGTCACCGTGCAAGCGCTGGGATGCGACGCCCGCCAGGTCGCGTTGAAG GCAGACACCGATAACTTCGAACAGGGCAAGTTCTTCCTGATCAGCGACAACAATAGGGAT AAGCTCTATGTCAATATACGGCCTACGGATAACTCCGCCTGGACGACCGACAATGGTGTC TTCTACAAAAACGATGTCGGGAGCTGGGGTGGAATTATCGGGATCTACGTAGATGGGCAA CAAACGAACACACCGCCCGGCAACTACACACTGACCCTGACCGGGGGTTACTGGGCAAAA TGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P24093 UniProtKB Entry Name DRAA_ECOLX GenBank Protein ID 145801 GenBank Gene ID M62834 - General References
- Swanson TN, Bilge SS, Nowicki B, Moseley SL: Molecular structure of the Dr adhesin: nucleotide sequence and mapping of receptor-binding domain by use of fusion constructs. Infect Immun. 1991 Jan;59(1):261-8. [Article]
- Kist ML, Salit IE, Hofmann T: Purification and characterization of the Dr hemagglutinins expressed by two uropathogenic Escherichia coli strains. Infect Immun. 1990 Mar;58(3):695-702. [Article]
Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00446 Chloramphenicol approved, vet_approved, withdrawn unknown antagonist Details DB07492 Bromamphenicol experimental unknown Details DB07565 Chloramphenicol succinate approved unknown inhibitor Details DB08621 Thiamphenicol experimental, investigational unknown Details