Thymidine kinase
Details
- Name
- Thymidine kinase
- Synonyms
- 2.7.1.21
- Gene Name
- TK
- Organism
- EHV-4
- Amino acid sequence
>lcl|BSEQ0016617|Thymidine kinase MAACVPPGEAPRSASGTPTRRQVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPE PMAYWRTLFETDVISGIYDTQNRKQQGNLAVDDAALITAHYQSRFTTPYLILHDHTCTLF GGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIV VTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPT SCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRN LNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
- Number of residues
- 352
- Molecular Weight
- 38784.035
- Theoretical pI
- 7.19
- GO Classification
- FunctionsATP binding / thymidine kinase activityProcessesDNA biosynthetic process / TMP biosynthetic process
- General Function
- Thymidine kinase activity
- Specific Function
- In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.
- Pfam Domain Function
- Herpes_TK (PF00693)
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0003820|1059 bp ATGGCTGCTTGCGTACCCCCGGGAGAAGCTCCACGAAGCGCCAGCGGAACGCCCACCCGG CGGCAAGTAACAATAGTTAGAATTTACCTCGATGGAGTTTATGGCATCGGTAAGAGCACG ACGGGACGAGTTATGGCATCGGCTGCTAGCGGAGGAAGTCCAACTCTATACTTTCCAGAG CCTATGGCGTACTGGCGGACTCTTTTTGAAACGGACGTAATTAGTGGTATTTACGACACC CAAAACCGGAAACAGCAGGGAAATTTGGCCGTTGATGACGCGGCATTAATAACTGCGCAT TACCAAAGCCGCTTTACCACGCCCTACCTGATACTCCACGATCACACTTGTACGTTGTTT GGGGGAAACAGCCTACAGCGTGGAACACAACCGGACCTGACCCTTGTGTTTGACCGCCAC CCGGTCGCCTCTACCGTATGCTTTCCAGCAGCCCGCTACCTACTCGGTGACATGTCAATG TGCGCGCTAATGGCTATGGTTGCTACTCTACCAAGAGAACCCCAGGGTGGTAACATTGTG GTTACCACCCTAAATGTAGAGGAGCATATACGGAGACTGCGTACGCGGGCTAGAATAGGA GAACAAATTGACATTACGCTGATTGCTACATTGCGAAATGTGTACTTTATGCTAGTTAAT ACATGTCACTTTTTGCGCTCTGGGCGAGTTTGGCGCGACGGTTGGGGTGAGCTACCCACT TCCTGTGGGGCTTATAAGCATCGCGCCACACAGATGGACGCCTTCCAAGAGCGCGTTTCA CCGGAGCTGGGCGACACTCTGTTTGCCCTGTTTAAAACTCAAGAACTGCTAGACGATCGC GGTGTAATATTGGAAGTTCACGCTTGGGCGTTGGACGCGCTTATGCTAAAACTGCGTAAC CTGAATGTTTTCAGTGCCGATTTAAGTGGTACACCGCGACAATGTGCAGCTGTTGTAGAG TCTTTGCTGCCACTTATGAGCAGCACCTTATCAGATTTTGATTCCGCCTCTGCTTTAGAG CGGGCGGCACGCACCTTTAACGCGGAGATGGGCGTCTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P24425 UniProtKB Entry Name KITH_EHV4 GenBank Protein ID 221822 GenBank Gene ID D14486 - General References
- Nicolson L, Cullinane AA, Onions DE: The nucleotide sequence of the equine herpesvirus 4 thymidine kinase gene. J Gen Virol. 1990 Aug;71 ( Pt 8):1801-5. [Article]
- Gardberg A, Shuvalova L, Monnerjahn C, Konrad M, Lavie A: Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases. Structure. 2003 Oct;11(10):1265-77. [Article]