Thymidine kinase

Details

Name
Thymidine kinase
Synonyms
  • 2.7.1.21
Gene Name
TK
Organism
EHV-4
Amino acid sequence
>lcl|BSEQ0016617|Thymidine kinase
MAACVPPGEAPRSASGTPTRRQVTIVRIYLDGVYGIGKSTTGRVMASAASGGSPTLYFPE
PMAYWRTLFETDVISGIYDTQNRKQQGNLAVDDAALITAHYQSRFTTPYLILHDHTCTLF
GGNSLQRGTQPDLTLVFDRHPVASTVCFPAARYLLGDMSMCALMAMVATLPREPQGGNIV
VTTLNVEEHIRRLRTRARIGEQIDITLIATLRNVYFMLVNTCHFLRSGRVWRDGWGELPT
SCGAYKHRATQMDAFQERVSPELGDTLFALFKTQELLDDRGVILEVHAWALDALMLKLRN
LNVFSADLSGTPRQCAAVVESLLPLMSSTLSDFDSASALERAARTFNAEMGV
Number of residues
352
Molecular Weight
38784.035
Theoretical pI
7.19
GO Classification
Functions
ATP binding / thymidine kinase activity
Processes
DNA biosynthetic process / TMP biosynthetic process
General Function
Thymidine kinase activity
Specific Function
In latent infection, may allow the virus to be reactivated and to grow in cells lacking a high concentration of phosphorylated nucleic acid precursors, such as nerve cells that do not replicate their genome.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0003820|1059 bp
ATGGCTGCTTGCGTACCCCCGGGAGAAGCTCCACGAAGCGCCAGCGGAACGCCCACCCGG
CGGCAAGTAACAATAGTTAGAATTTACCTCGATGGAGTTTATGGCATCGGTAAGAGCACG
ACGGGACGAGTTATGGCATCGGCTGCTAGCGGAGGAAGTCCAACTCTATACTTTCCAGAG
CCTATGGCGTACTGGCGGACTCTTTTTGAAACGGACGTAATTAGTGGTATTTACGACACC
CAAAACCGGAAACAGCAGGGAAATTTGGCCGTTGATGACGCGGCATTAATAACTGCGCAT
TACCAAAGCCGCTTTACCACGCCCTACCTGATACTCCACGATCACACTTGTACGTTGTTT
GGGGGAAACAGCCTACAGCGTGGAACACAACCGGACCTGACCCTTGTGTTTGACCGCCAC
CCGGTCGCCTCTACCGTATGCTTTCCAGCAGCCCGCTACCTACTCGGTGACATGTCAATG
TGCGCGCTAATGGCTATGGTTGCTACTCTACCAAGAGAACCCCAGGGTGGTAACATTGTG
GTTACCACCCTAAATGTAGAGGAGCATATACGGAGACTGCGTACGCGGGCTAGAATAGGA
GAACAAATTGACATTACGCTGATTGCTACATTGCGAAATGTGTACTTTATGCTAGTTAAT
ACATGTCACTTTTTGCGCTCTGGGCGAGTTTGGCGCGACGGTTGGGGTGAGCTACCCACT
TCCTGTGGGGCTTATAAGCATCGCGCCACACAGATGGACGCCTTCCAAGAGCGCGTTTCA
CCGGAGCTGGGCGACACTCTGTTTGCCCTGTTTAAAACTCAAGAACTGCTAGACGATCGC
GGTGTAATATTGGAAGTTCACGCTTGGGCGTTGGACGCGCTTATGCTAAAACTGCGTAAC
CTGAATGTTTTCAGTGCCGATTTAAGTGGTACACCGCGACAATGTGCAGCTGTTGTAGAG
TCTTTGCTGCCACTTATGAGCAGCACCTTATCAGATTTTGATTCCGCCTCTGCTTTAGAG
CGGGCGGCACGCACCTTTAACGCGGAGATGGGCGTCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP24425
UniProtKB Entry NameKITH_EHV4
GenBank Protein ID221822
GenBank Gene IDD14486
General References
  1. Nicolson L, Cullinane AA, Onions DE: The nucleotide sequence of the equine herpesvirus 4 thymidine kinase gene. J Gen Virol. 1990 Aug;71 ( Pt 8):1801-5. [Article]
  2. Gardberg A, Shuvalova L, Monnerjahn C, Konrad M, Lavie A: Structural basis for the dual thymidine and thymidylate kinase activity of herpes thymidine kinases. Structure. 2003 Oct;11(10):1265-77. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03280p1-(5'-adenosyl)p5-(5'-thymidyl)pentaphosphateexperimentalunknownligandDetails
DB04485Thymidineexperimental, investigationalunknownsubstrateDetails