Nitrite reductase
Details
- Name
- Nitrite reductase
- Synonyms
- 1.7.2.1
- Cytochrome cd1
- Cytochrome oxidase
- Hydroxylamine reductase
- Gene Name
- nirS
- Organism
- Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
- Amino acid sequence
>lcl|BSEQ0016537|Nitrite reductase MPFGKPLVGTLLASLTLLGLATAHAKDDMKAAEQYQGAASAVDPAHVVRTNGAPDMSESE FNEAKQIYFQRCAGCHGVLRKGATGKPLTPDITQQRGQQYLEALITYGTPLGMPNWGSSG ELSKEQITLMAKYIQHTPPQPPEWGMPEMRESWKVLVKPEDRPKKQLNDLDLPNLFSVTL RDAGQIALVDGDSKKIVKVIDTGYAVHISRMSASGRYLLVIGRDARIDMIDLWAKEPTKV AEIKIGIEARSVESSKFKGYEDRYTIAGAYWPPQFAIMDGETLEPKQIVSTRGMTVDTQT YHPEPRVAAIIASHEHPEFIVNVKETGKVLLVNYKDIDNLTVTSIGAAPFLHDGGWDSSH RYFMTAANNSNKVAVIDSKDRRLSALVDVGKTPHPGRGANFVHPKYGPVWSTSHLGDGSI SLIGTDPKNHPQYAWKKVAELQGQGGGSLFIKTHPKSSHLYVDTTFNPDARISQSVAVFD LKNLDAKYQVLPIAEWADLGEGAKRVVQPEYNKRGDEVWFSVWNGKNDSSALVVVDDKTL KLKAVVKDPRLITPTGKFNVYNTQHDVY
- Number of residues
- 568
- Molecular Weight
- 62652.855
- Theoretical pI
- 8.21
- GO Classification
- Functionselectron carrier activity / heme binding / hydroxylamine reductase activity / metal ion binding / nitrite reductase (NO-forming) activityComponentsperiplasmic space
- General Function
- Nitrite reductase (no-forming) activity
- Specific Function
- Not Available
- Pfam Domain Function
- Cytochrome_CBB3 (PF13442)
- Transmembrane Regions
- Not Available
- Cellular Location
- Periplasm
- Gene sequence
>lcl|BSEQ0016538|Nitrite reductase (nirS) ATGCCATTTGGCAAGCCACTGGTGGGCACCTTGCTCGCCTCGCTGACGCTGCTGGGCCTG GCCACCGCTCACGCCAAGGACGACATGAAAGCCGCCGAGCAATACCAGGGTGCCGCTTCC GCCGTCGATCCCGCTCACGTGGTGCGCACCAACGGTGCCCCCGACATGAGTGAAAGCGAG TTCAACGAGGCCAAGCAGATCTACTTCCAACGCTGCGCCGGTTGCCACGGCGTCCTGCGC AAGGGCGCCACCGGCAAGCCGCTGACCCCGGACATCACCCAGCAACGCGGCCAGCAATAC CTGGAAGCGCTGATCACCTACGGCACCCCGCTGGGCATGCCGAACTGGGGCAGCTCCGGC GAGCTGAGCAAGGAACAGATCACCCTGATGGCCAAGTACATCCAGCACACCCCGCCGCAA CCGCCGGAGTGGGGCATGCCGGAGATGCGCGAATCGTGGAAGGTGCTGGTGAAGCCGGAG GACCGGCCGAAGAAACAGCTCAACGACCTCGACCTGCCCAACCTGTTCTCGGTGACCCTG CGCGACGCCGGGCAGATCGCCCTGGTCGACGGCGACAGCAAGAAGATCGTCAAGGTCATC GATACCGGCTATGCCGTGCATATCTCGCGGATGTCCGCTTCCGGCCGCTACCTGCTGGTG ATCGGCCGCGACGCGCGGATCGACATGATCGACCTGTGGGCCAAGGAGCCGACCAAGGTC GCCGAGATCAAGATCGGCATCGAGGCGCGCTCGGTGGAAAGCTCCAAGTTCAAGGGCTAC GAGGACCGCTACACCATCGCCGGCGCCTACTGGCCGCCGCAGTTCGCGATCATGGACGGC GAGACCCTGGAACCGAAGCAGATCGTCTCCACCCGCGGCATGACCGTAGACACCCAGACC TACCACCCGGAACCGCGCGTGGCGGCGATCATCGCCTCCCACGAGCACCCCGAGTTCATC GTCAACGTGAAGGAGACCGGCAAGGTCCTGCTGGTCAACTACAAGGATATCGACAACCTC ACCGTCACCAGCATCGGTGCGGCGCCGTTCCTCCACGACGGCGGCTGGGACAGCAGCCAC CGCTACTTCATGACCGCCGCCAACAACTCCAACAAGGTTGCCGTGATCGACTCCAAGGAC CGTCGCCTGTCGGCCCTGGTCGACGTCGGCAAGACCCCGCACCCGGGGCGTGGCGCCAAC TTCGTGCATCCCAAGTACGGCCCGGTGTGGAGCACCAGCCACCTGGGCGACGGCAGCATC TCGCTGATCGGCACCGATCCGAAGAACCATCCGCAGTACGCCTGGAAGAAAGTCGCCGAA CTACAGGGCCAGGGCGGCGGCTCGCTGTTCATCAAGACCCATCCGAAGTCCTCGCACCTC TACGTCGACACCACCTTCAACCCCGACGCCAGGATCAGCCAGAGCGTCGCGGTGTTCGAC CTGAAGAACCTCGACGCCAAGTACCAGGTGCTGCCGATCGCCGAATGGGCCGATCTCGGC GAAGGCGCCAAGCGGGTGGTGCAGCCCGAGTACAACAAGCGCGGCGATGAAGTCTGGTTC TCGGTGTGGAACGGCAAGAACGACAGCTCCGCGCTGGTGGTGGTGGACGACAAGACCCTG AAGCTCAAGGCCGTGGTCAAGGACCCGCGGCTGATCACCCCGACCGGTAAGTTCAACGTC TACAACACCCAGCACGACGTGTACTGA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P24474 UniProtKB Entry Name NIRS_PSEAE GenBank Protein ID 45358 GenBank Gene ID X16452 - General References
- Silvestrini MC, Galeotti CL, Gervais M, Schinina E, Barra D, Bossa F, Brunori M: Nitrite reductase from Pseudomonas aeruginosa: sequence of the gene and the protein. FEBS Lett. 1989 Aug 28;254(1-2):33-8. [Article]
- Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]
- Arai H, Sanbongi Y, Igarashi Y, Kodama T: Cloning and sequencing of the gene encoding cytochrome c-551 from Pseudomonas aeruginosa. FEBS Lett. 1990 Feb 12;261(1):196-8. [Article]
- Nordling M, Young S, Karlsson BG, Lundberg LG: The structural gene for cytochrome c551 from Pseudomonas aeruginosa. The nucleotide sequence shows a location downstream of the nitrite reductase gene. FEBS Lett. 1990 Jan 1;259(2):230-2. [Article]
- Nurizzo D, Silvestrini MC, Mathieu M, Cutruzzola F, Bourgeois D, Fulop V, Hajdu J, Brunori M, Tegoni M, Cambillau C: N-terminal arm exchange is observed in the 2.15 A crystal structure of oxidized nitrite reductase from Pseudomonas aeruginosa. Structure. 1997 Sep 15;5(9):1157-71. [Article]
- Nurizzo D, Cutruzzola F, Arese M, Bourgeois D, Brunori M, Cambillau C, Tegoni M: Conformational changes occurring upon reduction and NO binding in nitrite reductase from Pseudomonas aeruginosa. Biochemistry. 1998 Oct 6;37(40):13987-96. [Article]
- Nurizzo D, Cutruzzola F, Arese M, Bourgeois D, Brunori M, Cambillau C, Tegoni M: Does the reduction of c heme trigger the conformational change of crystalline nitrite reductase? J Biol Chem. 1999 May 21;274(21):14997-5004. [Article]
- Cutruzzola F, Brown K, Wilson EK, Bellelli A, Arese M, Tegoni M, Cambillau C, Brunori M: The nitrite reductase from Pseudomonas aeruginosa: essential role of two active-site histidines in the catalytic and structural properties. Proc Natl Acad Sci U S A. 2001 Feb 27;98(5):2232-7. [Article]
- Brown K, Roig-Zamboni V, Cutruzzola' F, Arese M, Sun W, Brunori M, Cambillau C, Tegoni M: Domain swing upon His to Ala mutation in nitrite reductase of Pseudomonas aeruginosa. J Mol Biol. 2001 Sep 21;312(3):541-54. [Article]