Genome polyprotein

Details

Name
Genome polyprotein
Synonyms
  • 3.4.22.-
  • p23
Gene Name
Not Available
Organism
HCV
Amino acid sequence
>lcl|BSEQ0010867|Genome polyprotein
MSTNPKPQRKTKRNTNRRPQDVKFPGGGQIVGGVYLLPRRGPRLGVRATRKTSERSQPRG
RRQPIPKARRPEGRTWAQPGYPWPLYGNEGMGWAGWLLSPRGSRPSWGPTDPRRRSRNLG
KVIDTLTCGFADLMGYIPLVGAPLGGAARALAHGVRVLEDGVNYATGNLPGCSFSIFLLA
LLSCLTIPASAYEVRNVSGIYHVTNDCSNSSIVYEAADMIMHTPGCVPCVRESNFSRCWV
ALTPTLAARNSSIPTTTIRRHVDLLVGAAALCSAMYVGDLCGSVFLVSQLFTFSPRRYET
VQDCNCSIYPGHVSGHRMAWDMMMNWSPTTALVVSQLLRIPQAVVDMVAGAHWGVLAGLA
YYSMVGNWAKVLIVMLLFAGVDGHTHVTGGRVASSTQSLVSWLSQGPSQKIQLVNTNGSW
HINRTALNCNDSLQTGFIAALFYAHRFNASGCPERMASCRPIDEFAQGWGPITHDMPESS
DQRPYCWHYAPRPCGIVPASQVCGPVYCFTPSPVVVGTTDRFGAPTYSWGENETDVLLLS
NTRPPQGNWFGCTWMNSTGFTKTCGGPPCNIGGVGNNTLVCPTDCFRKHPEATYTKCGSG
PWLTPRCMVDYPYRLWHYPCTVNFTVFKVRMYVGGVEHRLNAACNWTRGERCDLEDRDRS
ELSPLLLSTTEWQILPCSFTTLPALSTGLIHLHRNIVDVQYLYGIGSAVVSFAIKWEYIL
LLFLLLADARVCACLWMMLLIAQAEATLENLVVLNAASVAGAHGLLSFLVFFCAAWYIKG
RLVPGAAYALYGVWPLLLLLLALPPRAYAMDREMAASCGGAVFVGLVLLTLSPYYKVFLA
RLIWWLQYFITRAEAHLQVWVPPLNVRGGRDAIILLTCAVHPELIFDITKLLLAILGPLM
VLQAGITRVPYFVRAQGLIRACMLVRKVAGGHYVQMAFMKLAALTGTYVYDHLTPLRDWA
HAGLRDLAVAVEPVVFSDMETKLITWGADTAACGDIISGLPVSARRGKEILLGPADSFGE
QGWRLLAPITAYSQQTRGLLGCIITSLTGRDKNQVDGEVQVLSTATQSFLATCVNGVCWT
VYHGAGSKTLAGPKGPITQMYTNVDQDLVGWPAPPGARSMTPCTCGSSDLYLVTRHADVV
PVRRRGDSRGSLLSPRPISYLKGSSGGPLLCPSGHVVGIFRAAVCTRGVAKAVDFIPVES
METTMRSPVFTDNSSPPAVPQTFQVAHLHAPTGSGKSTKVPAAYAAQGYKVLVLNPSVAA
TLGFGAYMSKAHGIEPNIRTGVRTITTGGPITYSTYCKFLADGGCSGGAYDIIICDECHS
TDSTTILGIGTVLDQAETAGARLVVLATATPPGSITVPHPNIEEVALSNTGEIPFYGKAI
PIEAIKGGRHLIFCHSKKKCDELAAKLTGLGLNAVAYYRGLDVSVIPTSGDVVVVATDAL
MTGFTGDFDSVIDCNTCVTQTVDFSLDPTFTIETTTLPQDAVSRAQRRGRTGRGRSGIYR
FVTPGERPSGMFDSSVLCECYDAGCAWYELTPAETSVRLRAYLNTPGLPVCQDHLEFWES
VFTGLTHIDAHFLSQTKQAGDNLPYLVAYQATVCARAQAPPPSWDQMWKCLIRLKPTLHG
PTPLLYRLGAVQNEVTLTHPITKYIMACMSADLEVVTSTWVLVGGVLAALAAYCLTTGSV
VIVGRIILSGRPAVIPDREVLYQEFDEMEECASHLPYIEQGMQLAEQFKQKALGLLQTAT
KQAEAAAPVVESKWRALEVFWAKHMWNFISGIQYLAGLSTLPGNPAIASLMAFTASITSP
LTTQNTLLFNILGGWVAAQLAPPSAASAFVGAGIAGAAVGSIGLGKVLVDILAGYGAGVA
GALVAFKVMSGEMPSTEDLVNLLPAILSPGALVVGVVCAAILRRHVGPGEGAVQWMNRLI
AFASRGNHVSPTHYVPESDAAARVTQILSSLTITQLLKRLHQWINEDCSTPCSGSWLKDV
WDWICTVLSDFKTWLQSKLLPRLPGLPFLSCQRGYKGVWRGDGIMQTTCPCGAQITGHVK
NGSMRIVGPKTCSNTWHGTFPINAYTTGPCTPSPAPNYSRALWRVAAEEYVEVTRVGDFH
YVTGMTTDNVKCPCQVPAPEFFTEVDGVRLHRYAPVCKPLLREEVVFQVGLNQYLVGSQL
PCEPEPDVAVLTSMLTDPSHITAETAKRRLARGSPPSLASSSASQLSAPSLKATCTTHHD
SPDADLIEANLLWRQEMGGNITRVESENKVVILDSFDPIRAVEDEREISVPAEILRKPRK
FPPALPIWARPDYNPPLLESWKDPDYVPPVVHGCPLPSTKAPPIPPPRRKRTVVLTESTV
SSALAELATKTFGSSGSSAVDSGTATGPPDQASDDGDKGSDVESYSSMPPLEGEPGDPDL
SDGSWSTVSGEAGEDVVCCSMSYTWTGALITPCAAEESKLPINPLSNSLLRHHSMVYSTT
SRSASLRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKARLLSIEEACKLTPPHSAKSKF
GYGAKDVRSLSSRAVNHIRSVWEDLLEDTETPIDTTIMAKNEVFCVQPEKGGRKPARLIV
FPDLGVRVCEKMALYDVVSTLPQAVMGPSYGFQYSPGQRVEFLVNTWKSKKCPMGFSYDT
RCFDSTVTENDIRTEESIYQCCDLAPEARQAIRSLTERLYVGGPLTNSKGQNCGYRRCRA
SGVLTTSCGNTLTCYLKATAACRAAKLQDCTMLVNGDDLVVICESAGTQEDAAALRAFTE
AMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETVR
HTPVNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDCQIYGACYSIEPLDLPQ
IIERLHGLSAFSLHSYSPGEINRVASCLRKLGVPPLRVWRHRARSVRAKLLSQGGRAATC
GKYLFNWAVKTKLKLTPIPAASQLDLSGWFVAGYNGGDIYHSLSRARPRWFMLCLLLLSV
GVGIYLLPNR
Number of residues
3010
Molecular Weight
327018.235
Theoretical pI
8.07
GO Classification
Functions
ATP binding / ATP-dependent helicase activity / cysteine-type endopeptidase activity / ion channel activity / RNA binding / RNA helicase activity / RNA-directed RNA polymerase activity / serine-type endopeptidase activity / structural molecule activity / zinc ion binding
Processes
apoptotic process / clathrin-mediated endocytosis of virus by host cell / fusion of virus membrane with host endosome membrane / induction by virus of host autophagy / modulation by virus of host G1/S transition checkpoint / negative regulation of apoptotic process / negative regulation of cell cycle G1/S phase transition / pore formation by virus in membrane of host cell / positive regulation of apoptotic process by virus / protein oligomerization / regulation of transcription, DNA-templated / suppression by virus of host MAVS activity / suppression by virus of host STAT1 activity / suppression by virus of host TRAF activity / suppression by virus of host type I interferon-mediated signaling pathway / transcription, DNA-templated / transformation of host cell by virus / viral RNA genome replication / virion attachment to host cell
Components
extracellular region / host cell cytoplasm / host cell cytosol / host cell endoplasmic reticulum membrane / host cell lipid particle / host cell mitochondrial membrane / host cell nucleus / host cell perinuclear region of cytoplasm / host cell plasma membrane / integral component of membrane / integral to membrane of host cell / viral envelope / viral nucleocapsid / virion membrane
General Function
Zinc ion binding
Specific Function
Core protein packages viral RNA to form a viral nucleocapsid, and promotes virion budding. Modulates viral translation initiation by interacting with HCV IRES and 40S ribosomal subunit. Also regulates many host cellular functions such as signaling pathways and apoptosis. Prevents the establishment of cellular antiviral state by blocking the interferon-alpha/beta (IFN-alpha/beta) and IFN-gamma signaling pathways and by inducing human STAT1 degradation. Thought to play a role in virus-mediated cell transformation leading to hepatocellular carcinomas. Interacts with, and activates STAT3 leading to cellular transformation. May repress the promoter of p53, and sequester CREB3 and SP110 isoform 3/Sp110b in the cytoplasm. Also represses cell cycle negative regulating factor CDKN1A, thereby interrupting an important check point of normal cell cycle regulation. Targets transcription factors involved in the regulation of inflammatory responses and in the immune response: suppresses NK-kappaB activation, and activates AP-1. Could mediate apoptotic pathways through association with TNF-type receptors TNFRSF1A and LTBR, although its effect on death receptor-induced apoptosis remains controversial. Enhances TRAIL mediated apoptosis, suggesting that it might play a role in immune-mediated liver cell injury. Seric core protein is able to bind C1QR1 at the T-cell surface, resulting in down-regulation of T-lymphocytes proliferation. May transactivate human MYC, Rous sarcoma virus LTR, and SV40 promoters. May suppress the human FOS and HIV-1 LTR activity. Alters lipid metabolism by interacting with hepatocellular proteins involved in lipid accumulation and storage. Core protein induces up-regulation of FAS promoter activity, and thereby probably contributes to the increased triglyceride accumulation in hepatocytes (steatosis) (By similarity).E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection (By similarity).P7 seems to be a heptameric ion channel protein (viroporin) and is inhibited by the antiviral drug amantadine. Also inhibited by long-alkyl-chain iminosugar derivatives. Essential for infectivity (By similarity).Protease NS2-3 is a cysteine protease responsible for the autocatalytic cleavage of NS2-NS3. Seems to undergo self-inactivation following maturation (By similarity).NS3 displays three enzymatic activities: serine protease, NTPase and RNA helicase. NS3 serine protease, in association with NS4A, is responsible for the cleavages of NS3-NS4A, NS4A-NS4B, NS4B-NS5A and NS5A-NS5B. NS3/NS4A complex also prevents phosphorylation of human IRF3, thus preventing the establishment of dsRNA induced antiviral state. NS3 RNA helicase binds to RNA and unwinds dsRNA in the 3' to 5' direction and likely RNA stable secondary structure in the template strand. Cleaves and inhibits the host antiviral protein MAVS (By similarity).NS4B induces a specific membrane alteration that serves as a scaffold for the virus replication complex. This membrane alteration gives rise to the so-called ER-derived membranous web that contains the replication complex.NS5A is a component of the replication complex involved in RNA-binding. Its interaction with Human VAPB may target the viral replication complex to vesicles. Down-regulates viral IRES translation initiation. Mediates interferon resistance, presumably by interacting with and inhibiting human EIF2AK2/PKR. Seems to inhibit apoptosis by interacting with BIN1 and FKBP8. The hyperphosphorylated form of NS5A is an inhibitor of viral replication.NS5B is an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
Pfam Domain Function
Transmembrane Regions
169-189 359-379 726-746 758-778 783-803 814-834 882-902 929-949 1658-1678 1806-1826 1829-1849 1851-1871 1882-1902 2990-3010
Cellular Location
Host endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0002478|9033 bp
ATGAGCACAAATCCTAAACCTCAAAGAAAAACCAAACGTAACACCAACCGCCGCCCACAG
GACGTTAAGTTCCCGGGCGGTGGTCAGATCGTTGGTGGAGTTTACCTGTTGCCGCGCAGG
GGCCCCAGGTTGGGTGTGCGCGCGACTAGGAAGACTTCCGAGCGGTCGCAACCTCGTGGA
AGGCGACAACCTATCCCCAAGGCTCGCCGGCCCGAGGGTAGGACCTGGGCTCAGCCCGGG
TACCCTTGGCCCCTCTATGGCAACGAGGGTATGGGGTGGGCAGGATGGCTCCTGTCACCC
CGTGGCTCTCGGCCTAGTTGGGGCCCCACAGACCCCCGGCGTAGGTCGCGTAATTTGGGT
AAGGTCATCGATACCCTTACATGCGGCTTCGCCGACCTCATGGGGTACATTCCGCTTGTC
GGCGCCCCCCTAGGGGGCGCTGCCAGGGCCCTGGCACATGGTGTCCGGGTTCTGGAGGAC
GGCGTGAACTATGCAACAGGGAATCTGCCCGGTTGCTCTTTCTCTATCTTCCTCTTAGCT
TTGCTGTCTTGTTTGACCATCCCAGCTTCCGCTTACGAGGTGCGCAACGTGTCCGGGATA
TACCATGTCACGAACGACTGCTCCAACTCAAGTATTGTGTATGAGGCAGCGGACATGATC
ATGCACACCCCCGGGTGCGTGCCCTGCGTCCGGGAGAGTAATTTCTCCCGTTGCTGGGTA
GCGCTCACTCCCACGCTCGCGGCCAGGAACAGCAGCATCCCCACCACGACAATACGACGC
CACGTCGATTTGCTCGTTGGGGCGGCTGCTCTCTGTTCCGCTATGTACGTTGGGGATCTC
TGCGGATCCGTTTTTCTCGTCTCCCAGCTGTTCACCTTCTCACCTCGCCGGTATGAGACG
GTACAAGATTGCAATTGCTCAATCTATCCCGGCCACGTATCAGGTCACCGCATGGCTTGG
GATATGATGATGAACTGGTCACCTACAACGGCCCTAGTGGTATCGCAGCTACTCCGGATC
CCACAAGCCGTCGTGGACATGGTGGCGGGGGCCCACTGGGGTGTCCTAGCGGGCCTTGCC
TACTATTCCATGGTGGGGAACTGGGCTAAGGTCTTGATTGTGATGCTACTCTTTGCTGGC
GTTGACGGGCACACCCACGTGACAGGGGGAAGGGTAGCCTCCAGCACCCAGAGCCTCGTG
TCCTGGCTCTCACAAGGCCCATCTCAGAAAATCCAACTCGTGAACACCAACGGCAGCTGG
CACATCAACAGGACCGCTCTGAATTGCAATGACTCCCTCCAAACTGGGTTCATTGCTGCG
CTGTTCTACGCACACAGGTTCAACGCGTCCGGGTGCCCAGAGCGCATGGCTAGCTGCCGC
CCCATCGATGAGTTCGCTCAGGGGTGGGGTCCCATCACTCATGATATGCCTGAGAGCTCG
GACCAGAGGCCATATTGCTGGCACTACGCGCCTCGACCGTGCGGGATCGTGCCTGCGTCG
CAGGTGTGTGGTCCAGTGTATTGCTTCACTCCGAGCCCTGTTGTAGTGGGGACGACCGAT
CGTTTCGGCGCTCCTACGTATAGCTGGGGGGAGAATGAGACAGACGTGCTGCTACTTAGC
AACACGCGGCCGCCTCAAGGCAACTGGTTTGGGTGCACGTGGATGAACAGCACTGGGTTC
ACCAAGACGTGCGGGGGCCCTCCGTGCAACATCGGGGGGGTCGGCAACAACACCTTGGTC
TGCCCCACGGATTGCTTCCGGAAGCACCCCGAGGCCACTTACACAAAGTGTGGCTCGGGG
CCCTGGTTGACACCCAGGTGCATGGTTGACTACCCATACAGGCTCTGGCACTACCCCTGC
ACTGTTAACTTTACCGTCTTTAAGGTCAGGATGTATGTGGGGGGCGTGGAGCACAGGCTC
AATGCTGCATGCAATTGGACTCGAGGAGAGCGCTGTGACTTGGAGGACAGGGATAGGTCA
GAACTCAGCCCGCTGCTGCTGTCTACAACAGAGTGGCAGATACTGCCCTGTTCCTTCACC
ACCCTACCGGCCCTGTCCACTGGCTTGATCCATCTTCACCGGAACATCGTGGACGTGCAA
TACCTGTACGGTATAGGGTCGGCAGTTGTCTCCTTTGCAATCAAATGGGAGTATATCCTG
TTGCTTTTCCTTCTTCTGGCGGACGCGCGCGTCTGTGCCTGCTTGTGGATGATGCTGCTG
ATAGCCCAGGCTGAGGCCACCTTAGAGAACCTGGTGGTCCTCAATGCGGCGTCTGTGGCC
GGAGCGCATGGCCTTCTCTCCTTCCTCGTGTTCTTCTGCGCCGCCTGGTACATCAAAGGC
AGGCTGGTCCCTGGGGCGGCATATGCTCTCTATGGCGTATGGCCGTTGCTCCTGCTCTTG
CTGGCCTTACCACCACGAGCTTATGCCATGGACCGAGAGATGGCTGCATCGTGCGGAGGC
GCGGTTTTTGTAGGTCTGGTACTCTTGACCTTGTCACCATACTATAAGGTGTTCCTCGCT
AGGCTCATATGGTGGTTACAATATTTTATCACCAGAGCCGAGGCGCACTTGCAAGTGTGG
GTCCCCCCTCTCAATGTTCGGGGAGGCCGCGATGCCATCATCCTCCTTACATGCGCGGTC
CATCCAGAGCTAATCTTTGACATCACCAAACTCCTGCTCGCCATACTCGGTCCGCTCATG
GTGCTCCAGGCTGGCATAACTAGAGTGCCGTACTTTGTACGCGCTCAGGGGCTCATCCGT
GCATGCATGTTAGTGCGGAAGGTCGCTGGAGGCCACTATGTCCAAATGGCCTTCATGAAG
CTGGCCGCGCTGACAGGTACGTACGTATATGACCATCTTACTCCACTGCGGGATTGGGCC
CACGCGGGCCTACGAGACCTTGCGGTGGCAGTAGAGCCCGTCGTCTTCTCTGACATGGAG
ACTAAACTCATCACCTGGGGGGCAGACACCGCGGCGTGTGGGGACATCATCTCGGGTCTA
CCAGTCTCCGCCCGAAGGGGGAAGGAGATACTTCTAGGACCGGCCGATAGTTTTGGAGAG
CAGGGGTGGCGGCTCCTTGCGCCTATCACGGCCTATTCCCAACAAACGCGGGGCCTGCTT
GGCTGTATCATCACTAGCCTCACAGGTCGGGACAAGAACCAGGTCGATGGGGAGGTTCAG
GTGCTCTCCACCGCAACGCAATCTTTCCTGGCGACCTGCGTCAATGGCGTGTGTTGGACC
GTCTACCATGGTGCCGGCTCGAAGACCCTGGCCGGCCCGAAGGGTCCAATCACCCAAATG
TACACCAATGTAGACCAGGACCTCGTCGGCTGGCCGGCGCCCCCCGGGGCGCGCTCCATG
ACACCGTGCACCTGCGGCAGCTCGGACCTTTACTTGGTCACGAGGCATGCTGATGTCGTT
CCGGTGCGCCGGCGGGGCGACAGCAGGGGGAGCCTGCTTTCCCCCAGGCCCATCTCCTAC
CTGAAGGGCTCCTCGGGTGGACCACTGCTTTGCCCTTCGGGGCACGTTGTAGGCATCTTC
CGGGCTGCTGTGTGCACCCGGGGGGTTGCGAAGGCGGTGGACTTCATACCCGTTGAGTCT
ATGGAAACTACCATGCGGTCTCCGGTCTTCACAGACAACTCATCCCCTCCGGCCGTACCG
CAAACATTCCAAGTGGCACATTTACACGCTCCCACTGGCAGCGGCAAGAGCACCAAAGTG
CCGGCTGCATATGCAGCCCAAGGGTACAAGGTGCTCGTCCTAAACCCGTCCGTTGCCGCC
ACATTGGGCTTTGGAGCGTATATGTCCAAGGCACATGGCATCGAGCCTAACATCAGAACT
GGGGTAAGGACCATCACCACGGGCGGCCCCATCACGTACTCCACCTATTGCAAGTTCCTT
GCCGACGGTGGATGCTCCGGGGGCGCCTATGACATCATAATATGTGATGAATGCCACTCA
ACTGACTCGACTACCATCTTGGGCATCGGCACAGTCCTGGATCAGGCAGAGACGGCTGGA
GCGCGGCTCGTCGTGCTCGCCACCGCCACGCCTCCGGGATCGATCACCGTGCCACACCCC
AACATCGAGGAAGTGGCCCTGTCCAACACTGGAGAGATTCCCTTCTATGGCAAAGCCATC
CCCATTGAGGCCATCAAGGGGGGAAGGCATCTCATCTTCTGCCATTCCAAGAAGAAGTGT
GACGAGCTCGCCGCAAAGCTGACAGGCCTCGGACTCAATGCTGTAGCGTATTACCGGGGT
CTCGATGTGTCCGTCATACCGACTAGCGGAGACGTCGTTGTCGTGGCAACAGACGCTCTA
ATGACGGGTTTTACCGGCGACTTTGACTCAGTGATCGACTGCAACACATGTGTCACCCAG
ACAGTCGATTTCAGCTTGGATCCCACCTTCACCATTGAGACGACAACGCTGCCCCAAGAC
GCGGTGTCGCGTGCGCAGCGGCGAGGTAGGACTGGCAGGGGCAGGAGTGGCATCTACAGG
TTTGTGACTCCAGGAGAACGGCCCTCAGGCATGTTCGACTCCTCGGTCCTGTGTGAGTGC
TATGACGCAGGCTGCGCTTGGTATGAGCTCACGCCCGCTGAGACCTCGGTTAGGTTGCGG
GCTTACCTAAATACACCAGGGTTGCCCGTCTGCCAGGACCACCTAGAGTTCTGGGAGAGC
GTCTTCACAGGCCTCACCCACATAGATGCCCACTTCTTGTCCCAGACCAAACAGGCAGGA
GACAACCTCCCCTACCTGGTAGCATACCAAGCCACAGTGTGCGCCAGGGCTCAGGCTCCA
CCTCCATCGTGGGACCAAATGTGGAAGTGTCTCATACGGCTAAAGCCCACACTGCATGGG
CCAACGCCCCTGCTGTACAGGCTAGGAGCCGTTCAAAATGAGGTCACTCTCACACACCCC
ATAACCAAATACATCATGGCATGCATGTCGGCTGACCTGGAGGTCGTCACTAGCACCTGG
GTGCTAGTAGGCGGAGTCCTTGCGGCTCTGGCCGCGTACTGCCTGACGACAGGCAGCGTG
GTCATTGTGGGCAGGATCATCTTGTCCGGGAGGCCAGCTGTTATTCCCGACAGGGAAGTC
CTCTACCAGGAGTTCGATGAGATGGAAGAGTGTGCTTCACACCTCCCTTACATCGAGCAA
GGAATGCAGCTCGCCGAGCAATTCAAACAGAAGGCGCTCGGATTGCTGCAAACAGCCACC
AAGCAAGCGGAGGCTGCTGCTCCCGTGGTGGAGTCCAAGTGGCGAGCCCTTGAGGTCTTC
TGGGCGAAACACATGTGGAACTTCATCAGCGGGATACAGTACTTGGCAGGCCTATCCACT
CTGCCTGGAAACCCCGCGATAGCATCATTGATGGCTTTTACAGCCTCTATCACCAGCCCG
CTCACCACCCAAAATACCCTCCTGTTTAACATCTTGGGGGGATGGGTGGCTGCCCAACTC
GCTCCCCCCAGCGCTGCTTCGGCTTTCGTGGGCGCCGGCATTGCCGGTGCGGCCGTTGGC
AGCATAGGTCTCGGGAAGGTACTTGTGGACATTCTGGCGGGCTATGGGGCGGGGGTGGCT
GGCGCACTCGTGGCCTTTAAGGTCATGAGCGGCGAGATGCCCTCCACTGAGGATCTGGTT
AATTTACTCCCTGCCATCCTTTCTCCTGGCGCCCTGGTTGTCGGGGTCGTGTGCGCAGCA
ATACTGCGTCGGCACGTGGGCCCGGGAGAGGGGGCTGTGCAGTGGATGAACCGGCTGATA
GCGTTCGCTTCGCGGGGTAACCACGTCTCCCCCACGCACTATGTGCCCGAGAGCGACGCC
GCGGCGCGTGTTACTCAGATCCTCTCCAGCCTTACCATCACTCAGTTGCTGAAGAGGCTT
CATCAGTGGATTAATGAGGACTGCTCCACGCCTTGTTCCGGCTCGTGGCTAAAGGATGTT
TGGGACTGGATATGCACGGTGTTGAGTGACTTCAAGACTTGGCTCCAGTCCAAGCTCCTG
CCGCGGTTACCGGGACTCCCTTTCCTGTCATGCCAACGCGGGTACAAGGGAGTCTGGCGG
GGGGATGGCATCATGCAAACCACCTGCCCATGTGGAGCACAGATCACCGGACATGTCAAA
AATGGCTCCATGAGGATTGTTGGGCCAAAAACCTGCAGCAACACGTGGCATGGAACATTC
CCCATCAACGCATACACCACGGGCCCCTGCACGCCCTCCCCAGCGCCGAACTATTCCAGG
GCGCTGTGGCGGGTGGCTGCTGAGGAGTACGTGGAGGTTACGCGGGTGGGGGATTTCCAC
TACGTGACGGGCATGACCACTGACAACGTGAAATGCCCATGCCAGGTTCCAGCCCCTGAA
TTTTTCACGGAGGTGGATGGAGTACGGTTGCACAGGTATGCTCCAGTGTGCAAACCTCTC
CTACGAGAGGAGGTCGTATTCCAGGTCGGGCTCAACCAGTACCTGGTCGGGTCACAGCTC
CCATGTGAGCCCGAACCGGATGTGGCAGTGCTCACTTCCATGCTCACCGACCCCTCTCAT
ATTACAGCAGAGACGGCCAAGCGTAGGCTGGCCAGGGGGTCTCCCCCCTCCTTGGCCAGC
TCTTCAGCTAGCCAGTTGTCTGCGCCTTCTTTGAAGGCGACATGTACTACCCATCATGAC
TCCCCGGACGCTGACCTCATCGAGGCCAACCTCCTGTGGCGGCAGGAGATGGGCGGGAAC
ATCACCCGTGTGGAGTCAGAAAATAAGGTGGTAATCCTGGACTCTTTCGATCCGATTCGG
GCGGTGGAGGATGAGAGGGAAATATCCGTCCCGGCGGAGATCCTGCGAAAACCCAGGAAG
TTCCCCCCAGCGTTGCCCATATGGGCACGCCCGGATTACAACCCTCCACTGCTAGAGTCC
TGGAAGGACCCGGACTACGTCCCCCCGGTGGTACACGGGTGCCCTTTGCCATCTACCAAG
GCCCCCCCAATACCACCTCCACGGAGGAAGAGGACGGTTGTCCTGACAGAGTCCACCGTG
TCTTCTGCCTTGGCGGAGCTCGCTACTAAGACCTTTGGCAGCTCCGGGTCGTCGGCCGTT
GACAGCGGCACGGCGACTGGCCCTCCCGATCAGGCCTCCGACGACGGCGACAAAGGATCC
GACGTTGAGTCGTACTCCTCCATGCCCCCCCTCGAGGGAGAGCCAGGGGACCCCGACCTC
AGCGACGGGTCTTGGTCTACCGTGAGCGGGGAAGCTGGTGAGGACGTCGTCTGCTGCTCA
ATGTCCTATACATGGACAGGTGCCTTGATCACGCCATGCGCTGCGGAGGAGAGCAAGTTG
CCCATCAATCCGTTGAGCAACTCTTTGCTGCGTCACCACAGTATGGTCTACTCCACAACA
TCTCGCAGCGCAAGTCTGCGGCAGAAGAAGGTCACCTTTGACAGACTGCAAGTCCTGGAC
GACCACTACCGGGACGTGCTCAAGGAGATGAAGGCGAAGGCGTCCACAGTTAAGGCTAGG
CTTCTATCTATAGAGGAGGCCTGCAAACTGACGCCCCCACATTCGGCCAAATCCAAATTT
GGCTACGGGGCGAAGGACGTCCGGAGCCTATCCAGCAGGGCCGTCAACCACATCCGCTCC
GTGTGGGAGGACTTGCTGGAAGACACTGAAACACCAATTGATACCACCATCATGGCAAAA
AATGAGGTTTTCTGCGTCCAACCAGAGAAAGGAGGCCGCAAGCCAGCTCGCCTTATCGTA
TTCCCAGACCTGGGGGTACGTGTATGCGAGAAGATGGCCCTTTACGACGTGGTCTCCACC
CTTCCTCAGGCCGTGATGGGCCCCTCATACGGATTCCAGTACTCTCCTGGGCAGCGGGTC
GAGTTCCTGGTGAATACCTGGAAATCAAAGAAATGCCCTATGGGCTTCTCATATGACACC
CGCTGCTTTGACTCAACGGTCACTGAGAATGACATCCGTACTGAGGAATCAATTTACCAA
TGTTGTGACTTGGCCCCCGAAGCCAGGCAGGCCATAAGGTCGCTCACAGAGCGGCTTTAT
GTCGGGGGTCCCCTGACTAATTCGAAGGGGCAGAACTGCGGTTATCGCCGGTGCCGCGCA
AGTGGCGTGCTGACGACTAGCTGCGGCAACACCCTCACATGTTACTTGAAGGCCACTGCG
GCCTGTCGAGCTGCAAAGCTCCAGGACTGCACGATGCTCGTGAACGGAGACGACCTTGTC
GTTATCTGTGAGAGTGCGGGAACCCAGGAGGATGCGGCGGCCCTACGAGCCTTCACGGAG
GCTATGACTAGGTATTCCGCCCCCCCCGGGGACCCGCCCCAACCAGAATACGACTTGGAG
CTGATAACGTCATGCTCCTCCAATGTGTCGGTCGCGCACGATGCATCCGGCAAAAGGGTG
TACTACCTCACCCGTGACCCCACCACCCCCCTCGCACGGGCTGCGTGGGAGACAGTTAGA
CACACTCCAGTCAACTCCTGGCTAGGCAATATCATCATGTATGCGCCCACCCTATGGGCG
AGGATGATTCTGATGACTCATTTCTTCTCTATCCTTCTAGCTCAGGAGCAACTTGAAAAA
GCCCTGGATTGTCAGATCTACGGGGCCTGTTACTCCATTGAGCCACTTGACCTACCTCAG
ATCATTGAACGACTCCATGGTCTTAGCGCATTTTCACTCCACAGTTACTCTCCAGGTGAG
ATCAATAGGGTGGCTTCATGCCTCAGGAAACTTGGGGTACCGCCTTTGCGAGTCTGGAGA
CATCGGGCCAGAAGTGTCCGCGCTAAGCTACTGTCCCAGGGGGGGAGGGCTGCCACTTGC
GGCAAGTACCTCTTCAACTGGGCAGTAAAGACCAAGCTTAAACTCACTCCAATCCCGGCT
GCGTCCCAGCTAGACTTGTCCGGCTGGTTCGTTGCTGGTTACAACGGGGGAGACATATAT
CACAGCCTGTCTCGTGCCCGACCCCGTTGGTTCATGTTGTGCCTACTCCTACTTTCTGTA
GGGGTAGGCATCTACCTGCTCCCCAACCGGTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP26662
UniProtKB Entry NamePOLG_HCVJA
GenBank Protein ID221611
GenBank Gene IDD90208
General References
  1. Kato N, Hijikata M, Ootsuyama Y, Nakagawa M, Ohkoshi S, Sugimura T, Shimotohno K: Molecular cloning of the human hepatitis C virus genome from Japanese patients with non-A, non-B hepatitis. Proc Natl Acad Sci U S A. 1990 Dec;87(24):9524-8. [Article]
  2. Kato N, Hijikata M, Nakagawa M, Ootsuyama Y, Muraiso K, Ohkoshi S, Shimotohno K: Molecular structure of the Japanese hepatitis C viral genome. FEBS Lett. 1991 Mar 25;280(2):325-8. [Article]
  3. Hijikata M, Mizushima H, Akagi T, Mori S, Kakiuchi N, Kato N, Tanaka T, Kimura K, Shimotohno K: Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus. J Virol. 1993 Aug;67(8):4665-75. [Article]
  4. Shih CM, Lo SJ, Miyamura T, Chen SY, Lee YH: Suppression of hepatitis B virus expression and replication by hepatitis C virus core protein in HuH-7 cells. J Virol. 1993 Oct;67(10):5823-32. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01720(2Z)-2-(Benzoylamino)-3-[4-(2-bromophenoxy)phenyl]acrylic acidexperimentalunknownDetails
DB04005Uridine 5'-triphosphateexperimental, investigationalunknownDetails