RNA-directed RNA polymerase L
Details
- Name
- RNA-directed RNA polymerase L
- Synonyms
- Large structural protein
- Protein L
- Replicase
- Transcriptase
- Gene Name
- L
- Organism
- HPIV-2
- Amino acid sequence
>lcl|BSEQ0010473|RNA-directed RNA polymerase L MAASSEILLPEVHLNSPIVKHKLIYYLLLGHFPHDLDISEISPLHNNDWDQIAREESNLA ERLGVAKSELIKRVPAFRATRWRSHAAVLIWPSCIPFLVKFLPHSKLQPVEQWYKLINAS CNTISDSIDRCMENISIKLTGKNNLFSRSRGTAGAGKNSKITLNDIQSIWESNKWQPNVS LWLTIKYQMRQLIMHQSSRQPTDLVHIVDTRSGLIVITPELVICFDRLNSVLMYFTFEMT LMVSDMFEGRMNVTALCTISHYLSPLGPRIDRLFSIVDELAQLLGDTVYKVIASLESLVY GCLQLKDPVVELAGSFHSFITQEIIDILIGSKALDKDESITVTTQLLDIFSNLSPDLIAE MLCLMRLWGHPTLTAAQVGKVRESMCAGKLLDFPTIMKTLAFFHTILINGYRRKKNGMWP PLILPKNASKSLIEFQHDNAEISYEYTLKHWKEISLIEFRKCFDFDPGEELSIFMKDKAI SAPRSDWMSVFRRSLIKQRHQRHHIPMPNPFNRRLLLNFLEDDSFDPVAELRYVTGGEYL QDDTFCASYSLKEKEIKPDGRIFAKLTNRMRSCQVIAEAILANHAGTLMKENGVVLNQLS LTKSLLTMSQIGIISEKAKRYTRDNISSQGFHTIKTDSKNKRKSKTASSYLTDPDDTFEL SACFITTDLAKYCLQWRYQTIIHFARTLNRMYGVPHLFEWIHLRLIRSTLYVGDPFNPPA ATDAFDLDKVLNGDIFIVSKGGIEGLCQKMWTMISISVIILSSAESKTRVMSMVQGDNQA IAVTTRVPRSLPSIQKKELAYAASKLFFERLRANNYGLGHQLKAQETIISSTFFIYSKRV FYQGRILTQALKNASKLCLTADVLGECTQASCSNSATTIMRLTENGVEKDTCYKLNIYQS IRQLTYDLIFPQYSIPGETISEIFLQHPRLISRIVLLPSQLGGLNYLACSRLFNRNIGDP LGTAVADLKRLIKCGALESWILYNLLARKPGKGSWATLAADPYSLNQEYLYPPTTILKRH TQNTLMEICRNPMLKGVFTDNAKEEENLLAKFLLDRDIVLPRVAHIIIDQSSIGRKKQIQ GFFDTTRTIMRRSFEIKPLSTKKTLSVIEYNTNYLSYNYPVILNPLPIPGYLNYITDQTC SIDISRSLRKLSWSSLLNGRTLEGLETPDPIEVVNGFLIVGTGDCDFCMQGDDKFTWFFL PMGIIIDGNPETNPPIRVPYIGSRTEERRVASMAYIKGATHSLKAALRGAGVYIWAFGDT VVNWNDALDIANTRVKISLEQLQTLTPLPTSANITHRLDDGATTLKFTPASSYAFSSYTH ISNDQQYLEIDQRVVDSNIIYQQLMITGLGIIETYHNPPIRTSTQEITLHLHTSSSCCVR SVDGCLICESNGEVPQITVPYTNTFVYDPDPLADYEIAHLDYLSYQAKIGSTDYYSLTDK IDLLAHLTAKQMINSIIGLDETVSIVNDAVILSDYTNNWISECSYTKIDLVFKLMAWNFL LELAFQMYYLRISSWTNIFDYTYMTLRRIPGTALNNIAATISHPKLLRRAMNLDIITPIH APYLASLDYVKLSIDAIQWGVKQVLADLSNGIDLEILILSEDSMEISDRAMNLIARKLTL LALVKGENYTFPKIKGMPPEEKCLVLTEYLAMCYQNTHHLDPDLQKYLYNLTNPKLTAFP SNNFYLTRKILNQIRESDEGQYIITSYYESFEQLETDIILHSTLTAPYDNSENSNKVRFI PFDIFPHPESLEKYPLPVDHDSQSAISTLIPGPPSHHVLRPLGVSSTAWYKGISYCRYLE TQKIQTGDHLYLAEGSGASMSLLELLFPGDTVYYNSLFSSGENPPQRNYAPLPTQFVQSV PYKLWQADLADDSNLIKDFVPLWNGNGAVTDLSTKDAVAFIIHKVGAEKASLVHIDLEST ANINQQTLSRSQIHSLIIATTVLKRGGILIYKTSWLPFSRFSQLAGLLWCFFDRIHLIRS SYSDPHSHEVYLVCRLAADFRTIGFSAALVTATTLHNDGFTTIHPDVVCSYWQHHLENVG RVGKVIDEILDGLATNFFAGDNGLILRCGGTPSSRKWLEIDQLASFDLVQDALVTLITIH LKEIIEVQSSHTEDYTSLLFTPYNIGAAGKVRTIIKLILERSLMYTVRNWLVLPSSIRDS VRQDLELGSFRLMSILSEQTFLKKTPTKKYLLDQLTRTYISTFFNSHSVLPLHRPYQKQI WKALGSVIYCSETVDIPLIKDIQIEDINDFEDIERGIDGEEL
- Number of residues
- 2262
- Molecular Weight
- 256380.115
- Theoretical pI
- 6.97
- GO Classification
- FunctionsATP binding / mRNA (guanine-N7-)-methyltransferase activity / RNA-directed RNA polymerase activityComponentshost cell cytoplasm / virion
- General Function
- Rna-directed rna polymerase activity
- Specific Function
- Displays RNA-directed RNA polymerase, mRNA guanylyl transferase, mRNA (guanine-N(7)-)-methyltransferase and poly(A) synthetase activities. The viral mRNA guanylyl transferase displays a different biochemical reaction than the cellular enzyme. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). Functions either as transcriptase or as replicase. The transcriptase synthesizes subsequently the subgenomic RNAs, assuring their capping and polyadenylation by a stuttering mechanism. The transcriptase stutters on a specific sequence, resulting on a cotranscriptional editing of the phosphoprotein (P) mRNA. The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing the transcriptional signals (By similarity).
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Virion
- Gene sequence
>lcl|BSEQ0010474|RNA-directed RNA polymerase L (L) ATGGCGGCCTCTTCTGAGATACTCCTTCCTGAAGTCCACTTGAACTCACCAATAGTCAAA CACAAACTCATATACTACTTATTACTAGGGCACTTCCCGCATGATCTTGACATTTCTGAA ATAAGCCCCCTTCACAATAATGATTGGGATCAAATTGCCAGAGAAGAATCCAATCTTGCT GAACGACTTGGAGTAGCTAAATCTGAATTAATTAAACGTGTGCCCGCATTTAGAGCAACT AGATGGCGTAGTCATGCAGCCGTCCTTATATGGCCTTCTTGTATACCATTTCTTGTTAAA TTCCTACCTCATTCTAAGCTTCAACCAGTAGAACAATGGTACAAGTTGATCAATGCTTCA TGTAATACTATATCTGACTCAATTGATAGATGTATGGAGAATATTTCTATTAAGCTTACT GGGAAAAACAATCTATTCTCTCGATCCAGAGGAACTGCAGGTGCAGGTAAAAACAGTAAA ATCACCCTCAATGATATCCAATCTATTTGGGAATCAAACAAGTGGCAACCTAATGTATCT TTATGGCTTACAATTAAATACCAAATGCGACAACTTATAATGCATCAAAGTTCTCGTCAG CCGACTGATTTAGTTCACATTGTTGACACACGATCTGGTCTAATAGTTATCACCCCTGAA CTTGTTATTTGTTTTGATCGGTTAAATAGTGTTTTAATGTATTTTACATTTGAGATGACT TTAATGGTAAGTGACATGTTTGAGGGAAGGATGAATGTCACCGCTCTCTGCACTATTAGT CATTACTTATCTCCACTAGGGCCAAGGATAGATAGATTGTTTTCCATTGTAGATGAATTA GCACAACTATTAGGTGACACTGTATATAAAGTTATTGCATCTCTTGAATCTTTAGTATAT GGGTGTCTACAACTTAAAGATCCAGTAGTGGAATTAGCAGGGTCATTTCATTCCTTTATT ACACAAGAGATTATAGATATCCTAATTGGTTCAAAAGCCCTTGATAAGGATGAATCAATA ACTGTTACTACACAATTGTTAGATATATTTTCCAACCTTTCTCCAGATTTAATTGCTGAG ATGTTGTGTCTCATGAGACTTTGGGGTCATCCCACTCTTACTGCTGCGCAAGTGGGTAAA GTGAGAGAATCTATGTGTGCAGGTAAGTTACTTGATTTCCCTACAATAATGAAAACTCTT GCTTTTTTCCACACAATTTTAATTAATGGTTACCGTAGAAAGAAAAATGGAATGTGGCCT CCACTTATACTTCCTAAAAATGCATCAAAAAGCTTAATAGAATTTCAACATGATAATGCT GAAATATCTTACGAATATACACTCAAGCATTGGAAAGAGATATCTCTCATAGAATTTAGA AAGTGCTTTGACTTTGATCCTGGTGAGGAGCTAAGCATTTTTATGAAAGACAAGGCAATA AGTGCTCCAAGAAGTGATTGGATGAGTGTATTTCGTAGAAGTCTAATAAAACAACGACAT CAGAGACATCATATTCCTATGCCCAATCCATTTAATAGACGTCTATTACTCAATTTCTTA GAAGATGACAGTTTTGATCCAGTTGCCGAGCTTCGATATGTTACCGGTGGTGAATATCTC CAAGATGACACATTTTGTGCATCTTACTCATTAAAAGAGAAAGAAATAAAACCAGATGGA AGGATATTTGCTAAGCTTACTAATAGAATGCGGTCCTGTCAAGTAATTGCGGAAGCAATT CTCGCAAATCATGCAGGTACTCTAATGAAGGAAAACGGAGTTGTCTTGAATCAATTATCA CTGACTAAATCATTGCTTACTATGAGTCAAATTGGCATAATATCAGAAAAGGCGAAGAGA TATACGCGAGATAACATCTCATCCCAAGGTTTCCATACAATCAAGACTGATTCTAAAAAT AAGAGGAAAAGCAAAACTGCATCATCATACCTCACAGATCCTGATGATACATTTGAACTT AGTGCATGTTTTATAACTACTGATCTTGCTAAATACTGTCTTCAATGGAGATATCAGACC ATAATCCATTTTGCTCGAACATTAAACAGAATGTATGGAGTTCCACATTTATTTGAATGG ATTCATCTTCGTTTAATTAGATCTACATTATATGTTGGTGATCCATTCAATCCTCCTGCC GCAACTGATGCTTTCGATCTAGATAAAGTATTAAATGGTGATATCTTTATAGTCTCCAAG GGAGGTATTGAAGGCCTATGTCAGAAAATGTGGACAATGATCTCTATTTCTGTGATCATC CTCTCTTCAGCCGAATCCAAAACAAGAGTAATGAGCATGGTTCAAGGAGATAATCAGGCG ATTGCAGTTACAACAAGAGTTCCTAGATCATTACCTAGTATTCAGAAAAAGGAGTTAGCC TATGCAGCAAGCAAGTTATTTTTTGAAAGACTTAGGGCAAATAATTATGGGTTGGGTCAT CAGCTAAAGGCTCAAGAAACTATAATAAGTTCCACGTTCTTCATATATAGTAAACGGGTA TTTTATCAAGGACGTATACTAACACAGGCACTCAAAAATGCTAGCAAGTTATGTCTTACT GCAGATGTATTAGGTGAATGTACTCAAGCTTCCTGTTCAAATTCTGCTACTACCATCATG AGATTAACAGAAAATGGGGTTGAGAAAGATACATGTTATAAGCTTAATATTTATCAGTCC ATTCGTCAACTCACATATGATCTAATATTTCCCCAATACTCCATACCAGGTGAAACTATA AGTGAGATTTTCCTACAGCATCCAAGACTAATCTCACGTATTGTTCTGCTCCCTTCACAG CTAGGTGGTCTTAATTACCTCGCATGTAGCAGATTATTTAACCGCAATATCGGAGATCCT CTTGGTACAGCTGTGGCAGATCTCAAGAGGTTAATTAAATGTGGTGCTCTTGAATCATGG ATACTGTATAATTTACTAGCAAGAAAACCAGGGAAAGGTTCATGGGCAACTTTAGCAGCC GATCCATACTCATTGAATCAAGAATATCTTTATCCTCCTACTACTATACTTAAAAGACAT ACTCAAAATACTTTAATGGAGATATGTCGGAATCCTATGTTAAAGGGAGTTTTTACAGAT AATGCAAAAGAGGAGGAAAATCTCCTTGCAAAATTTCTTCTTGATCGTGATATAGTATTG CCAAGAGTTGCACACATTATAATAGATCAATCTAGCATCGGAAGGAAGAAACAGATACAA GGATTTTTTGACACCACAAGGACCATAATGAGACGATCATTTGAAATCAAACCACTCTCA ACTAAGAAGACTCTTTCAGTCATAGAATATAATACTAATTACTTATCTTATAACTACCCT GTCATACTTAATCCTTTACCTATTCCTGGATATTTAAATTATATTACTGACCAAACTTGC AGTATTGATATATCTAGAAGTTTAAGAAAATTATCATGGTCTTCTTTATTGAATGGAAGA ACTTTAGAAGGATTAGAAACTCCAGATCCAATTGAAGTTGTCAATGGTTTCTTGATTGTA GGTACAGGAGATTGTGATTTTTGTATGCAGGGTGACGACAAATTTACTTGGTTCTTTTTA CCTATGGGGATAATTATTGATGGAAATCCTGAAACTAATCCACCCATCAGAGTTCCATAC ATTGGGTCTAGAACAGAGGAAAGAAGAGTTGCATCAATGGCATATATTAAAGGTGCCACA CACAGTTTGAAGGCTGCTCTTAGAGGCGCAGGGGTATATATTTGGGCATTCGGGGATACT GTAGTGAACTGGAATGATGCACTTGATATCGCAAATACTAGGGTTAAGATATCCCTAGAG CAACTTCAGACCCTTACACCTCTTCCTACATCTGCAAACATTACACACCGTTTAGATGAT GGAGCCACAACACTTAAATTCACTCCAGCTAGTTCCTATGCATTTTCTAGTTATACTCAT ATATCAAATGATCAACAATATTTAGAAATAGATCAGAGAGTAGTCGATTCTAATATTATT TATCAACAATTAATGATAACAGGACTTGGGATTATTGAGACCTACCATAACCCACCTATA AGGACTTCTACACAAGAAATCACTCTCCATTTGCACACTAGCTCATCTTGTTGTGTTAGA AGTGTAGATGGTTGCCTTATATGTGAGAGCAATGGAGAGGTTCCTCAGATCACTGTTCCC TATACTAATACATTTGTATATGATCCTGATCCACTAGCAGATTATGAGATTGCACACCTA GATTATCTCTCCTACCAAGCTAAAATTGGAAGTACAGATTACTACTCACTCACTGATAAA ATTGACCTATTAGCACATTTAACTGCAAAACAAATGATAAACTCAATAATTGGGTTAGAT GAAACAGTATCAATTGTCAATGATGCGGTTATCCTATCTGACTATACTAATAACTGGATT AGTGAATGTTCTTATACTAAGATAGATTTAGTTTTTAAATTAATGGCATGGAATTTCCTT CTTGAGCTTGCATTCCAGATGTACTACTTAAGGATATCATCTTGGACAAATATATTTGAC TATACTTATATGACTTTGCGCAGGATACCCGGAACTGCTCTAAATAATATTGCAGCTACT ATTAGCCATCCAAAATTATTAAGACGTGCAATGAATCTTGATATTATCACTCCTATACAT GCACCGTATTTAGCTTCATTAGATTATGTCAAATTAAGTATTGATGCAATTCAGTGGGGA GTTAAACAAGTTCTTGCTGATTTATCAAATGGAATTGATCTTGAAATCTTGATTCTTTCA GAGGATTCAATGGAAATTAGTGATAGGGCAATGAATCTCATTGCTAGAAAACTAACTCTC CTTGCACTTGTTAAAGGTGAGAACTATACTTTTCCAAAAATTAAAGGGATGCCACCAGAA GAAAAGTGTTTAGTCTTAACTGAATATCTAGCAATGTGTTATCAAAATACTCATCACTTA GATCCAGATCTTCAAAAGTATTTATATAATCTAACTAATCCAAAATTGACTGCATTTCCC AGTAACAACTTCTACTTAACTAGAAAAATCCTTAATCAAATTAGAGAATCAGACGAAGGA CAATATATTATCACCTCATATTATGAATCCTTCGAACAATTAGAAACAGATATAATTCTT CACTCTACTTTAACTGCTCCTTATGATAATTCAGAAAACTCTAACAAAGTTCGATTTATC CCTTTCGACATCTTTCCACATCCAGAATCTCTCGAGAAATATCCTCTTCCAGTTGATCAT GACTCTCAATCTGCAATTTCAACACTAATTCCAGGCCCTCCTTCTCATCATGTATTACGA CCACTAGGAGTGTCATCCACAGCTTGGTATAAAGGGATAAGTTATTGTAGATACCTAGAA ACACAAAAGATACAGACTGGTGATCATCTTTATTTAGCCGAAGGAAGCGGTGCTTCAATG TCACTTCTAGAACTCTTATTTCCAGGAGATACTGTCTATTATAATAGTCTTTTTAGTAGT GGAGAGAATCCTCCACAGAGAAACTATGCCCCTCTTCCAACTCAATTTGTACAGAGTGTT CCATATAAATTGTGGCAAGCTGATCTTGCTGATGATAGCAATTTGATAAAAGATTTTGTC CCATTATGGAATGGAAACGGTGCAGTTACAGACTTATCAACAAAGGATGCAGTTGCATTC ATAATACATAAAGTAGGAGCAGAGAAAGCATCCCTTGTCCATATAGATCTCGAATCAACT GCTAATATAAATCAGCAAACTCTGTCCAGATCCCAGATTCATTCATTAATTATAGCAACT ACTGTTCTTAAGAGGGGTGGGATATTAATTTATAAAACATCATGGCTTCCGTTTTCTAGG TTTAGTCAACTAGCAGGTCTACTTTGGTGCTTCTTTGACCGGATCCATCTAATACGTAGT AGCTATTCTGATCCTCACAGTCATGAGGTTTATCTTGTATGTAGACTTGCCGCAGATTTT AGAACTATCGGTTTCAGTGCAGCTCTAGTAACTGCTACTACTCTTCACAATGACGGATTC ACAACAATACATCCTGATGTTGTTTGTAGTTATTGGCAACACCATCTTGAAAATGTTGGG AGAGTCGGAAAAGTAATTGATGAGATACTTGATGGTTTAGCCACCAACTTCTTCGCAGGA GATAATGGGCTTATTCTAAGATGTGGAGGAACTCCAAGCTCCAGAAAATGGTTAGAGATT GACCAGTTAGCATCATTTGATTTGGTTCAAGATGCTCTGGTTACACTTATCACTATACAC CTAAAGGAAATTATAGAAGTGCAGTCATCACATACAGAGGATTATACATCTCTCCTCTTC ACACCTTATAATATTGGTGCAGCAGGGAAAGTCAGAACTATCATCAAATTAATTCTAGAA CGATCTTTAATGTATACAGTCCGAAATTGGTTAGTTTTACCCAGTTCCATCCGGGATTCT GTACGACAAGATTTAGAATTAGGGTCATTTAGATTAATGTCTATTTTAAGTGAACAGACA TTTCTTAAAAAGACACCCACAAAAAAATACTTACTTGATCAGCTTACAAGGACATATATA TCAACCTTCTTTAACTCTCACTCAGTCCTTCCCCTCCACCGTCCATATCAAAAACAAATA TGGAAAGCCTTAGGTAGTGTAATATATTGTTCGGAGACAGTTGATATACCTCTAATTAAA GACATTCAGATAGAAGATATTAATGATTTTGAAGATATCGAGAGGGGTATCGATGGCGAA GAATTATGA
- Chromosome Location
- Not Available
- Locus
- 6p21.3
- External Identifiers
Resource Link UniProtKB ID P26676 UniProtKB Entry Name L_PI2HT GenBank Protein ID 61991 GenBank Gene ID X57559 - General References
- Kawano M, Okamoto K, Bando H, Kondo K, Tsurudome M, Komada H, Nishio M, Ito Y: Characterizations of the human parainfluenza type 2 virus gene encoding the L protein and the intergenic sequences. Nucleic Acids Res. 1991 May 25;19(10):2739-46. [Article]