Ferredoxin--NADP reductase
Details
- Name
- Ferredoxin--NADP reductase
- Synonyms
- 1.18.1.2
- DA1
- Flavodoxin reductase
- FLDR
- FLXR
- FNR
- Methyl viologen resistance protein A
- mvrA
- Gene Name
- fpr
- Organism
- Escherichia coli (strain K12)
- Amino acid sequence
>lcl|BSEQ0005841|Ferredoxin--NADP reductase MADWVTGKVTKVQNWTDALFSLTVHAPVLPFTAGQFTKLGLEIDGERVQRAYSYVNSPDN PDLEFYLVTVPDGKLSPRLAALKPGDEVQVVSEAAGFFVLDEVPHCETLWMLATGTAIGP YLSILQLGKDLDRFKNLVLVHAARYAADLSYLPLMQELEKRYEGKLRIQTVVSRETAAGS LTGRIPALIESGELESTIGLPMNKETSHVMLCGNPQMVRDTQQLLKETRQMTKHLRRRPG HMTAEHYW
- Number of residues
- 248
- Molecular Weight
- 27750.735
- Theoretical pI
- 6.63
- GO Classification
- FunctionsFAD binding / ferredoxin-NADP+ reductase activity / oxidoreductase activityProcessesfructose catabolic process / response to drugComponentscytoplasm / cytosol
- General Function
- Oxidoreductase activity
- Specific Function
- Transports electrons between flavodoxin or ferredoxin and NADPH. Involved in the reductive activation of cobalamin-independent methionine synthase, pyruvate formate lyase and anaerobic ribonucleotide reductase. Also protects against superoxide radicals due to methyl viologen in the presence of oxygen.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0016950|Ferredoxin--NADP reductase (fpr) ATGGCTGATTGGGTAACAGGCAAAGTCACTAAAGTGCAGAACTGGACCGACGCCCTGTTT AGTCTCACCGTTCACGCCCCCGTGCTTCCGTTTACCGCCGGGCAATTTACCAAGCTTGGC CTTGAAATCGACGGCGAACGCGTCCAGCGCGCCTACTCCTATGTAAACTCGCCCGATAAT CCCGATCTGGAGTTTTACCTGGTCACCGTCCCCGATGGCAAATTAAGCCCACGACTGGCG GCACTGAAACCAGGCGATGAAGTGCAGGTGGTTAGCGAAGCGGCAGGATTCTTTGTGCTC GATGAAGTGCCGCACTGCGAAACGCTATGGATGCTGGCAACCGGTACAGCGATTGGCCCT TATTTATCGATTCTGCAACTAGGTAAAGATTTAGATCGCTTCAAAAATCTGGTCCTGGTG CACGCCGCACGTTATGCCGCCGACTTAAGCTATTTGCCACTGATGCAGGAACTGGAAAAA CGCTACGAAGGAAAACTGCGCATTCAGACGGTGGTCAGTCGGGAAACGGCAGCGGGGTCG CTCACCGGACGGATACCGGCATTAATTGAAAGTGGGGAACTGGAAAGCACGATTGGCCTG CCGATGAATAAAGAAACCAGCCATGTGATGCTGTGCGGCAATCCACAGATGGTGCGCGAT ACACAACAGTTGCTGAAAGAGACCCGGCAGATGACGAAACATTTACGTCGCCGACCGGGC CATATGACAGCGGAGCATTACTGGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P28861 UniProtKB Entry Name FENR_ECOLI GenBank Gene ID L04757 - General References
- Bianchi V, Reichard P, Eliasson R, Pontis E, Krook M, Jornvall H, Haggard-Ljungquist E: Escherichia coli ferredoxin NADP+ reductase: activation of E. coli anaerobic ribonucleotide reduction, cloning of the gene (fpr), and overexpression of the protein. J Bacteriol. 1993 Mar;175(6):1590-5. [Article]
- Plunkett G 3rd, Burland V, Daniels DL, Blattner FR: Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes. Nucleic Acids Res. 1993 Jul 25;21(15):3391-8. [Article]
- Blattner FR, Plunkett G 3rd, Bloch CA, Perna NT, Burland V, Riley M, Collado-Vides J, Glasner JD, Rode CK, Mayhew GF, Gregor J, Davis NW, Kirkpatrick HA, Goeden MA, Rose DJ, Mau B, Shao Y: The complete genome sequence of Escherichia coli K-12. Science. 1997 Sep 5;277(5331):1453-62. [Article]
- Hayashi K, Morooka N, Yamamoto Y, Fujita K, Isono K, Choi S, Ohtsubo E, Baba T, Wanner BL, Mori H, Horiuchi T: Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Mol Syst Biol. 2006;2:2006.0007. Epub 2006 Feb 21. [Article]
- Truniger V, Boos W, Sweet G: Molecular analysis of the glpFKX regions of Escherichia coli and Shigella flexneri. J Bacteriol. 1992 Nov;174(21):6981-91. [Article]
- Morimyo M: Isolation and characterization of methyl viologen-sensitive mutants of Escherichia coli K-12. J Bacteriol. 1988 May;170(5):2136-42. [Article]
- Jenkins CM, Waterman MR: Flavodoxin and NADPH-flavodoxin reductase from Escherichia coli support bovine cytochrome P450c17 hydroxylase activities. J Biol Chem. 1994 Nov 4;269(44):27401-8. [Article]
- Ingelman M, Bianchi V, Eklund H: The three-dimensional structure of flavodoxin reductase from Escherichia coli at 1.7 A resolution. J Mol Biol. 1997 Apr 25;268(1):147-57. [Article]