Adenosine receptor A2a
Details
- Name
- Adenosine receptor A2a
- Synonyms
- ADORA2
- Gene Name
- ADORA2A
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001840|Adenosine receptor A2a MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAI PFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTR AKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYF NFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVG LFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFR KIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNG YALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
- Number of residues
- 412
- Molecular Weight
- 44706.925
- Theoretical pI
- 8.05
- GO Classification
- Functionsenzyme binding / G-protein coupled adenosine receptor activity / identical protein bindingProcessesactivation of adenylate cyclase activity / adenylate cyclase-modulating G-protein coupled receptor signaling pathway / apoptotic process / astrocyte activation / blood circulation / blood coagulation / cAMP biosynthetic process / cell-cell signaling / cellular defense response / cellular protein metabolic process / central nervous system development / eating behavior / excitatory postsynaptic potential / inflammatory response / inhibitory postsynaptic potential / locomotory behavior / membrane depolarization / negative regulation of alpha-beta T cell activation / negative regulation of cell proliferation / negative regulation of cysteine-type endopeptidase activity involved in apoptotic process / negative regulation of inflammatory response / negative regulation of locomotion / negative regulation of neuron apoptotic process / negative regulation of protein kinase activity / negative regulation of vascular permeability / neuron projection morphogenesis / neurotrophin TRK receptor signaling pathway / phagocytosis / positive regulation of acetylcholine secretion, neurotransmission / positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway / positive regulation of apoptotic signaling pathway / positive regulation of circadian sleep/wake cycle, sleep / positive regulation of glutamate secretion / positive regulation of protein secretion / positive regulation of renal sodium excretion / positive regulation of synaptic transmission, GABAergic / positive regulation of synaptic transmission, glutamatergic / positive regulation of urine volume / prepulse inhibition / protein kinase C-activating G-protein coupled receptor signaling pathway / regulation of calcium ion transport / regulation of mitochondrial membrane potential / regulation of norepinephrine secretion / regulation of synaptic plasticity / regulation of transcription, DNA-templated / response to amphetamine / response to caffeine / response to drug / sensory perception / synaptic transmission, cholinergic / synaptic transmission, dopaminergic / synaptic transmission, glutamatergic / transmembrane receptor protein tyrosine kinase signaling pathway / vasodilationComponentsasymmetric synapse / axolemma / dendrite / endomembrane system / integral component of plasma membrane / intermediate filament / membrane / neuronal cell body / plasma membrane / postsynaptic density / postsynaptic membrane / presynaptic active zone / presynaptic membrane
- General Function
- Identical protein binding
- Specific Function
- Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 8-32 43-66 78-100 121-143 174-198 235-258 267-290
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0016254|Adenosine receptor A2a (ADORA2A) ATGCCCATCATGGGCTCCTCGGTGTACATCACGGTGGAGCTGGCCATTGCTGTGCTGGCC ATCCTGGGCAATGTGCTGGTGTGCTGGGCCGTGTGGCTCAACAGCAACCTGCAGAACGTC ACCAACTACTTTGTGGTGTCACTGGCGGCGGCCGACATCGCAGTGGGTGTGCTCGCCATC CCCTTTGCCATCACCATCAGCACCGGGTTCTGCGCTGCCTGCCACGGCTGCCTCTTCATT GCCTGCTTCGTCCTGGTCCTCACGCAGAGCTCCATCTTCAGTCTCCTGGCCATCGCCATT GACCGCTACATTGCCATCCGCATCCCGCTCCGGTACAATGGCTTGGTGACCGGCACGAGG GCTAAGGGCATCATTGCCATCTGCTGGGTGCTGTCGTTTGCCATCGGCCTGACTCCCATG CTAGGTTGGAACAACTGCGGTCAGCCAAAGGAGGGCAAGAACCACTCCCAGGGCTGCGGG GAGGGCCAAGTGGCCTGTCTCTTTGAGGATGTGGTCCCCATGAACTACATGGTGTACTTC AACTTCTTTGCCTGTGTGCTGGTGCCCCTGCTGCTCATGCTGGGTGTCTATTTGCGGATC TTCCTGGCGGCGCGACGACAGCTGAAGCAGATGGAGAGCCAGCCTCTGCCGGGGGAGCGG GCACGGTCCACACTGCAGAAGGAGGTCCATGCTGCCAAGTCACTGGCCATCATTGTGGGG CTCTTTGCCCTCTGCTGGCTGCCCCTACACATCATCAACTGCTTCACTTTCTTCTGCCCC GACTGCAGCCACGCCCCTCTCTGGCTCATGTACCTGGCCATCGTCCTCTCCCACACCAAT TCGGTTGTGAATCCCTTCATCTACGCCTACCGTATCCGCGAGTTCCGCCAGACCTTCCGC AAGATCATTCGCAGCCACGTCCTGAGGCAGCAAGAACCTTTCAAGGCAGCTGGCACCAGT GCCCGGGTCTTGGCAGCTCATGGCAGTGACGGAGAGCAGGTCAGCCTCCGTCTCAACGGC CACCCGCCAGGAGTGTGGGCCAACGGCAGTGCTCCCCACCCTGAGCGGAGGCCCAATGGC TATGCCCTGGGGCTGGTGAGTGGAGGGAGTGCCCAAGAGTCCCAGGGGAACACGGGCCTC CCAGACGTGGAGCTCCTTAGCCATGAGCTCAAGGGAGTGTGCCCAGAGCCCCCTGGCCTA GATGACCCCCTGGCCCAGGATGGAGCAGGAGTGTCCTGA
- Chromosome Location
- 22
- Locus
- 22q11.23
- External Identifiers
Resource Link UniProtKB ID P29274 UniProtKB Entry Name AA2AR_HUMAN GenBank Protein ID 177892 GenBank Gene ID M97370 GenAtlas ID ADORA2A HGNC ID HGNC:263 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00201 Caffeine approved yes antagonist Details DB04853 Binodenoson investigational unknown Details DB04932 Defibrotide approved, investigational unknown Details DB05191 Atl146e investigational unknown Details DB05009 Apadenoson investigational unknown Details DB00277 Theophylline approved yes antagonist Details DB06213 Regadenoson approved, investigational yes agonist Details DB00358 Mefloquine approved, investigational unknown antagonist Details DB00640 Adenosine approved, investigational yes agonist Details DB08770 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol experimental unknown Details DB00806 Pentoxifylline approved, investigational yes agonist Details DB00651 Dyphylline approved yes antagonist Details DB01303 Oxtriphylline approved yes antagonist Details DB01412 Theobromine investigational yes antagonist Details DB00824 Enprofylline approved, experimental unknown inhibitor Details DB09273 Doxofylline experimental unknown antagonist Details DB00555 Lamotrigine approved, investigational unknown inhibitor Details DB14132 8-chlorotheophylline experimental yes antagonist Details DB11757 Istradefylline approved, investigational yes antagonist Details DB17080 KW-6356 experimental yes antagonist Details DB00683 Midazolam approved, illicit unknown potentiator Details