Nicotinate-nucleotide pyrophosphorylase [carboxylating]

Details

Name
Nicotinate-nucleotide pyrophosphorylase [carboxylating]
Synonyms
  • 2.4.2.19
  • QAPRTase
  • Quinolinate phosphoribosyltransferase [decarboxylating]
Gene Name
nadC
Organism
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
Amino acid sequence
>lcl|BSEQ0016392|Nicotinate-nucleotide pyrophosphorylase [carboxylating]
MPPRRYNPDDRRDALLERINLDIPAAVAQALREDLGGEVDAGNDITAQLLPADTQAHATV
ITREDGVFCGKRWVEEVFIQLAGDDVRLTWHVDDGDAIHANQTVFELNGPARVLLTGERT
ALNFVQTLSGVASEVRRYVGLLAGTQTQLLDTRKTLPGLRTALKYAVLCGGGANHRLGLT
DAFLIKENHIIASGSVRQAVEKAFWLHPDVPVEVEVENLDELDDALKAGADIIMLDNFNT
DQMREAVKRVNGQARLEVSGNVTAETLREFAETGVDFISVGALTKHVRALDLSMRFC
Number of residues
297
Molecular Weight
32559.53
Theoretical pI
4.73
GO Classification
Functions
nicotinate-nucleotide diphosphorylase (carboxylating) activity
Processes
NAD biosynthetic process
General Function
Nicotinate-nucleotide diphosphorylase (carboxylating) activity
Specific Function
Involved in the catabolism of quinolinic acid (QA).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0016393|Nicotinate-nucleotide pyrophosphorylase [carboxylating] (nadC)
ATGCCGCCTCGCCGTTATAACCCAGACGACCGACGTGACGCGCTACTGGAACGCATTAAT
CTCGATATCCCTGCCGCCGTTGCTCAGGCGCTGCGTGAAGATTTAGGTGGAGAAGTCGAT
GCTGGCAACGATATCACCGCGCAACTTTTGCCGGCAGATACGCAAGCCCATGCCACGGTG
ATCACTCGTGAAGACGGCGTTTTCTGCGGCAAGCGCTGGGTTGAAGAGGTCTTCATCCAA
CTGGCGGGCGATGATGTGCGCCTCACCTGGCATGTCGATGACGGCGACGCCATTCACGCC
AACCAAACAGTGTTTGAACTGAACGGCCCGGCTCGCGTATTGCTGACCGGCGAGCGCACG
GCGCTAAACTTTGTCCAGACCCTTTCCGGCGTCGCCAGTGAAGTACGCCGCTACGTTGGA
CTGTTGGCTGGCACCCAAACCCAGTTGCTCGACACGCGTAAAACGCTGCCGGGTCTGCGC
ACCGCGCTCAAATATGCGGTTTTATGCGGCGGCGGCGCCAATCATCGTCTGGGCCTCACT
GACGCGTTCCTGATTAAAGAAAACCATATTATCGCCTCCGGTTCGGTTCGTCAGGCGGTG
GAAAAAGCGTTCTGGCTACATCCGGACGTGCCGGTAGAAGTCGAGGTCGAAAATCTGGAT
GAACTGGACGATGCGCTGAAAGCAGGCGCGGATATTATCATGCTGGATAATTTCAACACC
GACCAGATGCGCGAGGCGGTGAAACGCGTCAACGGCCAGGCGCGGCTGGAAGTATCCGGC
AACGTCACCGCGGAAACCTTACGCGAATTTGCTGAAACCGGGGTGGATTTCATCTCCGTT
GGCGCGCTGACCAAGCACGTGCGCGCGCTCGATCTCTCCATGCGTTTTTGCTGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP30012
UniProtKB Entry NameNADC_SALTY
GenBank Protein ID415621
GenBank Gene IDL07292
General References
  1. Hughes KT, Dessen A, Gray JP, Grubmeyer C: The Salmonella typhimurium nadC gene: sequence determination by use of Mud-P22 and purification of quinolinate phosphoribosyltransferase. J Bacteriol. 1993 Jan;175(2):479-86. [Article]
  2. McClelland M, Sanderson KE, Spieth J, Clifton SW, Latreille P, Courtney L, Porwollik S, Ali J, Dante M, Du F, Hou S, Layman D, Leonard S, Nguyen C, Scott K, Holmes A, Grewal N, Mulvaney E, Ryan E, Sun H, Florea L, Miller W, Stoneking T, Nhan M, Waterston R, Wilson RK: Complete genome sequence of Salmonella enterica serovar Typhimurium LT2. Nature. 2001 Oct 25;413(6858):852-6. [Article]
  3. Eads JC, Ozturk D, Wexler TB, Grubmeyer C, Sacchettini JC: A new function for a common fold: the crystal structure of quinolinic acid phosphoribosyltransferase. Structure. 1997 Jan 15;5(1):47-58. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01796Quinolinic AcidexperimentalunknownDetails