Calsequestrin-1
Details
- Name
- Calsequestrin-1
- Synonyms
- Calmitine
- Calsequestrin, skeletal muscle isoform
- CASQ
- Gene Name
- CASQ1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0049492|Calsequestrin-1 MSATDRMGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNV FKKYEVLALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKK LGLTEVDSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEI KLIGYFKSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPV TIPDKPNSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFL ETLKAVAQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWME MDDEEDLPSAEELEDWLEDVLEGEINTEDDDDDDDD
- Number of residues
- 396
- Molecular Weight
- 45159.635
- Theoretical pI
- Not Available
- GO Classification
- Functionscalcium ion bindingProcessesendoplasmic reticulum organization / ion transmembrane transport / protein polymerization / regulation of cardiac conduction / regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion / response to denervation involved in regulation of muscle adaptation / response to heat / response to organic substance / sarcomere organization / skeletal muscle tissue developmentComponentsendoplasmic reticulum / Golgi apparatus / I band / mitochondrial matrix / mitochondrion / sarcoplasmic reticulum / sarcoplasmic reticulum lumen / sarcoplasmic reticulum membrane / smooth endoplasmic reticulum / T-tubule / terminal cisterna lumen
- General Function
- Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. Calcium ions are bound by clusters of acidic residues at the protein surface, often at the interface between subunits. Can bind around 80 Ca(2+) ions. Regulates the release of lumenal Ca(2+) via the calcium release channel RYR1; this plays an important role in triggering muscle contraction.
- Specific Function
- Calcium ion binding
- Pfam Domain Function
- Calsequestrin (PF01216)
- Transmembrane Regions
- Not Available
- Cellular Location
- Sarcoplasmic reticulum
- Gene sequence
>lcl|BSEQ0049493|Calsequestrin-1 (CASQ1) ATGAGTGCTACAGACAGGATGGGGCCCAGAGCTGTGCCGGGTCTGCGGCTGGCACTGCTG TTGCTGCTGGTGCTAGGGACACCCAAGTCAGGGGTACAGGGGCAGGAAGGGCTGGACTTC CCTGAGTACGATGGTGTGGACCGTGTGATCAATGTCAATGCAAAGAACTACAAGAATGTG TTCAAGAAGTATGAGGTGCTGGCACTCCTCTACCATGAACCCCCCGAGGATGACAAGGCC TCACAAAGACAATTTGAGATGGAGGAGCTGATCCTGGAGTTAGCAGCCCAAGTCCTAGAA GACAAGGGTGTTGGCTTCGGGCTGGTAGACTCTGAGAAGGATGCAGCTGTGGCCAAGAAA CTAGGCCTAACTGAAGTGGACAGCATGTATGTATTCAAGGGAGATGAAGTCATTGAGTAC GATGGCGAGTTTTCTGCTGACACCATCGTGGAGTTTCTGCTTGATGTCCTAGAGGACCCT GTGGAATTGATTGAAGGTGAACGAGAGCTGCAGGCGTTTGAGAATATTGAGGATGAGATC AAACTCATTGGCTACTTCAAGAGCAAAGACTCAGAGCATTACAAAGCCTTCGAGGATGCA GCTGAGGAGTTTCATCCCTACATCCCCTTCTTCGCCACCTTCGACAGCAAGGTGGCAAAG AAGCTGACCCTGAAGCTGAATGAGATTGATTTCTACGAGGCCTTCATGGAAGAGCCTGTG ACCATCCCAGACAAGCCCAATAGCGAAGAGGAGATTGTCAACTTCGTGGAGGAGCACAGG AGATCAACCCTGAGGAAACTGAAGCCGGAGAGTATGTATGAGACCTGGGAGGATGATATG GATGGAATCCACATTGTGGCCTTCGCAGAGGAAGCTGATCCTGATGGTTTCGAGTTCTTA GAGACTCTCAAGGCTGTGGCCCAAGATAACACTGAAAACCCAGATCTTAGCATCATCTGG ATTGACCCTGATGACTTCCCCCTGCTGGTCCCATACTGGGAGAAGACGTTTGACATCGAC TTGTCAGCCCCACAAATAGGAGTCGTCAATGTTACTGATGCGGATAGCGTATGGATGGAA ATGGACGATGAGGAGGACCTGCCTTCTGCTGAGGAGCTGGAGGACTGGCTGGAGGATGTC CTGGAGGGCGAGATCAACACAGAGGACGATGACGATGATGATGATGACTAG
- Chromosome Location
- 1
- Locus
- 1q23.2
- External Identifiers
Resource Link UniProtKB ID P31415 UniProtKB Entry Name CASQ1_HUMAN HGNC ID HGNC:1512 - General References
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- Sanchez EJ, Lewis KM, Danna BR, Kang C: High-capacity Ca2+ binding of human skeletal calsequestrin. J Biol Chem. 2012 Mar 30;287(14):11592-601. doi: 10.1074/jbc.M111.335075. Epub 2012 Feb 15. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB11093 Calcium citrate approved, investigational no ligand Details DB11348 Calcium Phosphate approved no ligand Details DB13800 Calcium levulinate approved, experimental unknown agonist Details DB14481 Calcium phosphate dihydrate approved no Details