Cytidine deaminase

Details

Name
Cytidine deaminase
Synonyms
  • 3.5.4.5
  • CDD
  • Cytidine aminohydrolase
Gene Name
CDA
Organism
Humans
Amino acid sequence
>lcl|BSEQ0011748|Cytidine deaminase
MAQKRPACTLKPECVQQLLVCSQEAKKSAYCPYSHFPVGAALLTQEGRIFKGCNIENACY
PLGICAERTAIQKAVSEGYKDFRAIAIASDMQDDFISPCGACRQVMREFGTNWPVYMTKP
DGTYIVMTVQELLPSSFGPEDLQKTQ
Number of residues
146
Molecular Weight
16184.545
Theoretical pI
6.95
GO Classification
Functions
cytidine deaminase activity / nucleoside binding / protein homodimerization activity / zinc ion binding
Processes
cell surface receptor signaling pathway / cytidine deamination / cytosine metabolic process / negative regulation of cell growth / negative regulation of nucleotide metabolic process / nucleobase-containing small molecule metabolic process / protein homotetramerization / pyrimidine nucleobase metabolic process / pyrimidine nucleoside salvage / pyrimidine-containing compound salvage / small molecule metabolic process
Components
cytosol / extracellular region
General Function
Zinc ion binding
Specific Function
This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0011749|Cytidine deaminase (CDA)
ATGGCCCAGAAGCGTCCTGCCTGCACCCTGAAGCCTGAGTGTGTCCAGCAGCTGCTGGTT
TGCTCCCAGGAGGCCAAGAAGTCAGCCTACTGCCCCTACAGTCACTTTCCTGTGGGGGCT
GCCCTGCTCACCCAGGAGGGGAGAATCTTCAAAGGGTGCAACATAGAAAATGCCTGCTAC
CCGCTGGGCATCTGTGCTGAACGGACCGCTATCCAGAAGGCCGTCTCAGAAGGGTACAAG
GATTTCAGGGCAATTGCTATCGCCAGTGACATGCAAGATGATTTTATCTCTCCATGTGGG
GCCTGCAGGCAAGTCATGAGAGAGTTTGGCACCAACTGGCCCGTGTACATGACCAAGCCG
GATGGTACGTATATTGTCATGACGGTCCAGGAGCTGCTGCCCTCCTCCTTTGGGCCTGAG
GACCTGCAGAAGACCCAGTGA
Chromosome Location
1
Locus
1p36.2-p35
External Identifiers
ResourceLink
UniProtKB IDP32320
UniProtKB Entry NameCDD_HUMAN
GenBank Gene IDL27943
GenAtlas IDCDA
HGNC IDHGNC:1712
General References
  1. Laliberte J, Momparler RL: Human cytidine deaminase: purification of enzyme, cloning, and expression of its complementary DNA. Cancer Res. 1994 Oct 15;54(20):5401-7. [Article]
  2. Demontis S, Terao M, Brivio M, Zanotta S, Bruschi M, Garattini E: Isolation and characterization of the gene coding for human cytidine deaminase. Biochim Biophys Acta. 1998 Dec 22;1443(3):323-33. [Article]
  3. Gran C, Boyum A, Johansen RF, Lovhaug D, Seeberg EC: Growth inhibition of granulocyte-macrophage colony-forming cells by human cytidine deaminase requires the catalytic function of the protein. Blood. 1998 Jun 1;91(11):4127-35. [Article]
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  5. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  6. Kuhn K, Bertling WM, Emmrich F: Cloning of a functional cDNA for human cytidine deaminase (CDD) and its use as a marker of monocyte/macrophage differentiation. Biochem Biophys Res Commun. 1993 Jan 15;190(1):1-7. [Article]
  7. Chung SJ, Fromme JC, Verdine GL: Structure of human cytidine deaminase bound to a potent inhibitor. J Med Chem. 2005 Feb 10;48(3):658-60. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB031851-Beta-Ribofuranosyl-1,3-DiazepinoneexperimentalunknownDetails
DB00441GemcitabineapprovedunknownsubstrateDetails
DB00987Cytarabineapproved, investigationalunknownsubstrateDetails
DB00928Azacitidineapproved, investigationalunknownsubstrateDetails
DB01101Capecitabineapproved, investigationalnosubstrateDetails
DB031851-Beta-Ribofuranosyl-1,3-DiazepinoneexperimentalunknownligandDetails
DB15694Cedazuridineapproved, investigationalyesinhibitorDetails
DB01262Decitabineapproved, investigationalnosubstrateDetails