Cytochrome P450 2C19

Details

Name
Cytochrome P450 2C19
Synonyms
  • (R)-limonene 6-monooxygenase
  • (S)-limonene 6-monooxygenase
  • (S)-limonene 7-monooxygenase
  • 1.14.13.-
  • CYPIIC17
  • CYPIIC19
  • Cytochrome P450-11A
  • Cytochrome P450-254C
  • Mephenytoin 4-hydroxylase
Gene Name
CYP2C19
Organism
Human
Amino acid sequence
>lcl|BSEQ0020694|Cytochrome P450 2C19
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKI
YGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRW
KEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICS
IIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFM
ESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTE
TTSTTLRYALLLLLKHPEVTAKVQEEIERVVGRNRSPCMQDRGHMPYTDAVVHEVQRYID
LIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFK
KSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVP
PFYQLCFIPV
Number of residues
490
Molecular Weight
55930.545
Theoretical pI
7.42
GO Classification
Functions
arachidonic acid epoxygenase activity / oxidoreductase activity / steroid hydroxylase activity / iron ion binding / (R)-limonene 6-monooxygenase activity / heme binding / (S)-limonene 6-monooxygenase activity / monooxygenase activity / (S)-limonene 7-monooxygenase activity / oxygen binding / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen / enzyme binding
Processes
oxidation-reduction process / steroid metabolic process / xenobiotic metabolic process / arachidonic acid metabolic process / drug metabolic process / epoxygenase P450 pathway / exogenous drug catabolic process / heterocycle metabolic process / monoterpenoid metabolic process / small molecule metabolic process / omega-hydroxylase P450 pathway
Components
cytoplasm / endoplasmic reticulum membrane / intracellular membrane-bounded organelle
General Function
Steroid hydroxylase activity
Specific Function
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Endoplasmic reticulum membrane
Gene sequence
>lcl|BSEQ0020695|Cytochrome P450 2C19 (CYP2C19)
ATGGATCCTTTTGTGGTCCTTGTGCTCTGTCTCTCATGTTTGCTTCTCCTTTCAATCTGG
AGACAGAGCTCTGGGAGAGGAAAACTCCCTCCTGGCCCCACTCCTCTCCCAGTGATTGGA
AATATCCTACAGATAGATATTAAGGATGTCAGCAAATCCTTAACCAATCTCTCAAAAATC
TATGGCCCTGTGTTCACTCTGTATTTTGGCCTGGAACGCATGGTGGTGCTGCATGGATAT
GAAGTGGTGAAGGAAGCCCTGATTGATCTTGGAGAGGAGTTTTCTGGAAGAGGCCATTTC
CCACTGGCTGAAAGAGCTAACAGAGGATTTGGAATCGTTTTCAGCAATGGAAAGAGATGG
AAGGAGATCCGGCGTTTCTCCCTCATGACGCTGCGGAATTTTGGGATGGGGAAGAGGAGC
ATTGAGGACCGTGTTCAAGAGGAAGCCCGCTGCCTTGTGGAGGAGTTGAGAAAAACCAAG
GCTTCACCCTGTGATCCCACTTTCATCCTGGGCTGTGCTCCCTGCAATGTGATCTGCTCC
ATTATTTTCCAGAAACGTTTCGATTATAAAGATCAGCAATTTCTTAACTTGATGGAAAAA
TTGAATGAAAACATCAGGATTGTAAGCACCCCCTGGATCCAGATATGCAATAATTTTCCC
ACTATCATTGATTATTTCCCGGGAACCCATAACAAATTACTTAAAAACCTTGCTTTTATG
GAAAGTGATATTTTGGAGAAAGTAAAAGAACACCAAGAATCGATGGACATCAACAACCCT
CGGGACTTTATTGATTGCTTCCTGATCAAAATGGAGAAGGAAAAGCAAAACCAACAGTCT
GAATTCACTATTGAAAACTTGGTAATCACTGCAGCTGACTTACTTGGAGCTGGGACAGAG
ACAACAAGCACAACCCTGAGATATGCTCTCCTTCTCCTGCTGAAGCACCCAGAGGTCACA
GCTAAAGTCCAGGAAGAGATTGAACGTGTCATTGGCAGAAACCGGAGCCCCTGCATGCAG
GACAGGGGCCACATGCCCTACACAGATGCTGTGGTGCACGAGGTCCAGAGATACATCGAC
CTCATCCCCACCAGCCTGCCCCATGCAGTGACCTGTGACGTTAAATTCAGAAACTACCTC
ATTCCCAAGGGCACAACCATATTAACTTCCCTCACTTCTGTGCTACATGACAACAAAGAA
TTTCCCAACCCAGAGATGTTTGACCCTCGTCACTTTCTGGATGAAGGTGGAAATTTTAAG
AAAAGTAACTACTTCATGCCTTTCTCAGCAGGAAAACGGATTTGTGTGGGAGAGGGCCTG
GCCCGCATGGAGCTGTTTTTATTCCTGACCTTCATTTTACAGAACTTTAACCTGAAATCT
CTGATTGACCCAAAGGACCTTGACACAACTCCTGTTGTCAATGGATTTGCTTCTGTCCCG
CCCTTCTATCAGCTGTGCTTCATTCCTGTCTGA
Chromosome Location
10
Locus
10q24.1-q24.3
External Identifiers
ResourceLink
UniProtKB IDP33261
UniProtKB Entry NameCP2CJ_HUMAN
GenBank Protein ID181344
GenBank Gene IDM61854
HGNC IDHGNC:2621
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00188Bortezomibapproved, investigationalnosubstrateinhibitorDetails
DB00213PantoprazoleapprovedunknownsubstrateinhibitorDetails
DB00215CitalopramapprovedunknownsubstrateinhibitorDetails
DB00220NelfinavirapprovedunknownsubstrateinhibitorDetails
DB00231Temazepamapproved, investigationalunknownsubstrateDetails
DB00252Phenytoinapproved, vet_approvedunknownsubstrateDetails
DB00273TopiramateapprovedunknowninhibitorDetails
DB00328Indomethacinapproved, investigationalunknownsubstrateinhibitorDetails
DB00338Omeprazoleapproved, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00349Clobazamapproved, illicitunknownsubstrateDetails
DB00395CarisoprodolapprovedunknownsubstrateDetails
DB00396Progesteroneapproved, vet_approvedunknownsubstrateinhibitorDetails
DB00420Promazineapproved, vet_approvedunknownsubstrateDetails
DB00444TeniposideapprovedunknownsubstrateDetails
DB00448Lansoprazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00546AdinazolamexperimentalunknownsubstrateDetails
DB00582Voriconazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00665Nilutamideapproved, investigationalunknownsubstrateinhibitorDetails
DB00679Thioridazineapproved, withdrawnunknownsubstrateDetails
DB00736Esomeprazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB00738Pentamidineapproved, investigationalunknownsubstrateDetails
DB00794Primidoneapproved, vet_approvedunknownsubstrateinducerDetails
DB00849MethylphenobarbitalapprovedunknownsubstrateDetails
DB00863RanitidineapprovedunknownsubstrateDetails
DB00949FelbamateapprovedunknowninhibitorDetails
DB00983Formoterolapproved, investigationalunknownsubstrateDetails
DB01018Guanfacineapproved, investigationalunknownsubstrateDetails
DB01060Amoxicillinapproved, vet_approvedunknownsubstrateDetails
DB01104SertralineapprovedunknownsubstrateinhibitorDetails
DB01124Tolbutamideapproved, investigationalunknownsubstrateDetails
DB01129Rabeprazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB01131ProguanilapprovedunknownsubstrateDetails
DB01166Cilostazolapproved, investigationalunknownsubstrateDetails
DB01171Moclobemideapproved, investigationalunknownsubstrateinhibitorDetails
DB01174Phenobarbitalapproved, investigationalunknownsubstrateinducerDetails
DB01274Arformoterolapproved, investigationalunknownsubstrateDetails
DB01320Fosphenytoinapproved, investigationalunknownsubstrateDetails
DB01544Flunitrazepamapproved, illicitunknownsubstrateDetails
DB00176Fluvoxamineapproved, investigationalunknowninhibitorDetails
DB00197Troglitazoneinvestigational, withdrawnunknownsubstrateinhibitorDetails
DB00208TiclopidineapprovedunknownsubstrateinhibitorDetails
DB00321AmitriptylineapprovedunknownsubstrateinhibitorDetails
DB00343Diltiazemapproved, investigationalunknownsubstrateDetails
DB00455Loratadineapproved, investigationalunknowninhibitorinducerDetails
DB00458ImipramineapprovedunknownsubstrateinhibitorDetails
DB00503Ritonavirapproved, investigationalunknowninhibitorinducerDetails
DB00532Mephenytoinapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB00586Diclofenacapproved, vet_approvedunknownsubstrateDetails
DB00622Nicardipineapproved, investigationalunknowninhibitorDetails
DB00625Efavirenzapproved, investigationalunknowninhibitorDetails
DB00745Modafinilapproved, investigationalunknowninhibitorDetails
DB00752Tranylcypromineapproved, investigationalunknowninhibitorDetails
DB00776OxcarbazepineapprovedunknowninhibitorDetails
DB00927FamotidineapprovedunknownsubstrateDetails
DB00967Desloratadineapproved, investigationalunknowninhibitorDetails
DB01026Ketoconazoleapproved, investigationalunknowninhibitorDetails
DB01041Thalidomideapproved, investigational, withdrawnunknownsubstrateinhibitorDetails
DB01211ClarithromycinapprovedunknownsubstrateDetails
DB01424Aminophenazoneapproved, withdrawnunknownsubstrateinhibitorDetails
DB00333MethadoneapprovedunknownsubstrateDetails
DB06442AvasimibeinvestigationalunknownDetails
DB01065Melatoninapproved, nutraceutical, vet_approvedunknownsubstrateDetails
DB01076AtorvastatinapprovedunknowninhibitorDetails
DB00641SimvastatinapprovedunknownsubstrateDetails
DB01095FluvastatinapprovedunknowninhibitorDetails
DB00196Fluconazoleapproved, investigationalunknowninhibitorDetails
DB00619ImatinibapprovedunknownsubstrateDetails
DB00468QuinineapprovedunknownsubstrateinhibitorDetails
DB01142Doxepinapproved, investigationalunknownsubstrateDetails
DB01435Antipyrineapproved, investigationalunknownsubstrateinhibitorDetails
DB00250Dapsoneapproved, investigationalunknownsubstrateDetails
DB00675TamoxifenapprovedunknownsubstrateDetails
DB05109Trabectedinapproved, investigationalunknownsubstrateDetails
DB01418Acenocoumarolapproved, investigationalunknownsubstrateDetails
DB00682WarfarinapprovedunknownsubstrateinhibitorDetails
DB00540NortriptylineapprovedunknownsubstrateDetails
DB00285VenlafaxineapprovedunknownsubstrateDetails
DB00857Terbinafineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00972AzelastineapprovedunknownsubstrateinhibitorDetails
DB01075Diphenhydramineapproved, investigationalunknownsubstrateDetails
DB00829Diazepamapproved, illicit, investigational, vet_approvedunknownsubstrateinhibitorDetails
DB00446Chloramphenicolapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01242Clomipramineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00758ClopidogrelapprovedunknownsubstrateDetails
DB00531Cyclophosphamideapproved, investigationalunknownsubstrateDetails
DB01355HexobarbitalexperimentalunknownsubstrateDetails
DB00571Propranololapproved, investigationalunknownsubstrateDetails
DB00501Cimetidineapproved, investigationalunknowninhibitorDetails
DB00472Fluoxetineapproved, vet_approvedunknownsubstrateinhibitorDetails
DB01032Probenecidapproved, investigationalunknowninhibitorDetails
DB06403Ambrisentanapproved, investigationalunknownsubstrateDetails
DB01175Escitalopramapproved, investigationalunknownsubstrateDetails
DB06414EtravirineapprovedunknownsubstrateinhibitorDetails
DB01181IfosfamideapprovedunknownsubstrateDetails
DB05246MethsuximideapprovedunknownsubstrateinhibitorDetails
DB00726TrimipramineapprovedunknownsubstrateDetails
DB00357Aminoglutethimideapproved, investigationalunknowninducerDetails
DB00564Carbamazepineapproved, investigationalunknowninhibitorinducerDetails
DB01601LopinavirapprovedunknowninhibitorDetails
DB01045RifampicinapprovedunknowninducerDetails
DB06413Armodafinilapproved, investigationalunknowninhibitorDetails
DB00705DelavirdineapprovedunknowninhibitorDetails
DB01241GemfibrozilapprovedunknowninhibitorDetails
DB00951Isoniazidapproved, investigationalunknowninhibitorDetails
DB06268Sitaxentanapproved, investigational, withdrawnunknowninhibitorDetails
DB00216Eletriptanapproved, investigationalunknownsubstrateDetails
DB00363ClozapineapprovedunknownsubstrateinhibitorDetails
DB00470Dronabinolapproved, illicitunknownsubstrateDetails
DB00425ZolpidemapprovedunknownsubstrateDetails
DB01036Tolterodineapproved, investigationalunknownsubstrateDetails
DB01283Lumiracoxibapproved, investigationalunknownsubstrateDetails
DB00203Sildenafilapproved, investigationalunknownsubstrateinhibitorDetails
DB00672Chlorpropamideapproved, investigationalunknownsubstrateDetails
DB01120GliclazideapprovedunknownsubstrateinhibitorDetails
DB01016GlyburideapprovedunknownsubstrateDetails
DB01098RosuvastatinapprovedunknownsubstrateDetails
DB06739SeratrodastexperimentalunknownsubstrateDetails
DB06697ArtemetherapprovedunknownsubstrateinducerDetails
DB00945Acetylsalicylic acidapproved, vet_approvedunknowninducerDetails
DB01118Amiodaroneapproved, investigationalunknownsubstrateinhibitorDetails
DB00701Amprenavirapproved, investigationalunknowninhibitorDetails
DB00673Aprepitantapproved, investigationalunknownsubstrateinhibitorDetails
DB00289AtomoxetineapprovedunknownsubstrateDetails
DB00245BenzatropineapprovedunknownsubstrateDetails
DB01558Bromazepamapproved, illicit, investigationalunknownsubstrateDetails
DB00835BrompheniramineapprovedunknownsubstrateDetails
DB00297Bupivacaineapproved, investigationalunknownsubstrateDetails
DB00921Buprenorphineapproved, illicit, investigational, vet_approvedunknowninhibitorDetails
DB00748CarbinoxamineapprovedunknownsubstrateDetails
DB00091Cyclosporineapproved, investigational, vet_approvedunknowninhibitorDetails
DB00604Cisaprideapproved, investigational, withdrawnunknownsubstrateDetails
DB06470ClomethiazoleinvestigationalunknownsubstrateDetails
DB01559Clotiazepamapproved, illicitunknownsubstrateDetails
DB01151Desipramineapproved, investigationalunknownsubstrateDetails
DB01234Dexamethasoneapproved, investigational, vet_approvedunknowninducerDetails
DB00514DextromethorphanapprovedunknownsubstrateDetails
DB01093Dimethyl sulfoxideapproved, vet_approvedunknowninhibitorDetails
DB00988DopamineapprovedunknownsubstrateDetails
DB00590DoxazosinapprovedunknownsubstrateDetails
DB00783Estradiolapproved, investigational, vet_approvedunknownsubstrateDetails
DB00898EthanolapprovedunknowninhibitorDetails
DB01628Etoricoxibapproved, investigationalunknowninhibitorDetails
DB00499Flutamideapproved, investigationalunknownsubstrateDetails
DB01296Glucosamineapproved, investigationalunknownsubstrateDetails
DB00502HaloperidolapprovedunknownsubstrateDetails
DB01050IbuprofenapprovedunknownsubstrateDetails
DB06738KetobemidoneexperimentalunknownsubstrateDetails
DB00678LosartanapprovedunknowninhibitorDetails
DB01043Memantineapproved, investigationalunknowninhibitorDetails
DB00371Meprobamateapproved, illicitunknownsubstrateDetails
DB00703MethazolamideapprovedunknowninhibitorDetails
DB00264Metoprololapproved, investigationalunknownsubstrateDetails
DB01110Miconazoleapproved, investigational, vet_approvedunknowninhibitorDetails
DB00184NicotineapprovedunknownsubstrateDetails
DB06712NilvadipineinvestigationalunknowninhibitorDetails
DB00717NorethisteroneapprovedunknowninducerDetails
DB00334Olanzapineapproved, investigationalunknowninhibitorDetails
DB00312Pentobarbitalapproved, investigational, vet_approvedunknownsubstrateDetails
DB00850PerphenazineapprovedunknownsubstrateDetails
DB00454MeperidineapprovedunknownsubstrateDetails
DB03783PhenacetinwithdrawnunknownsubstrateDetails
DB00780PhenelzineapprovedunknowninhibitorDetails
DB01058Praziquantelapproved, investigational, vet_approvedunknownsubstrateDetails
DB00635Prednisoneapproved, vet_approvedunknowninducerDetails
DB00818Propofolapproved, investigational, vet_approvedunknownsubstrateDetails
DB01589Quazepamapproved, illicitunknownsubstrateDetails
DB01224QuetiapineapprovedunknownsubstrateDetails
DB01037Selegilineapproved, investigational, vet_approvedunknownsubstrateDetails
DB00259SulfanilamideapprovedunknowninhibitorDetails
DB00966Telmisartanapproved, investigationalunknowninhibitorDetails
DB00624Testosteroneapproved, investigationalunknownsubstrateDetails
DB00763MethimazoleapprovedunknowninhibitorDetails
DB00373TimololapprovedunknownsubstrateDetails
DB01007TioconazoleapprovedunknowninhibitorDetails
DB00347TrimethadioneapprovedunknownsubstrateDetails
DB00313Valproic Acidapproved, investigationalunknownsubstrateinhibitorDetails
DB00661VerapamilapprovedunknownsubstrateDetails
DB00549Zafirlukastapproved, investigationalunknowninhibitorDetails
DB00909Zonisamideapproved, investigationalunknownsubstrateinhibitorDetails
DB00398Sorafenibapproved, investigationalunknowninhibitorDetails
DB00932Tipranavirapproved, investigationalunknownsubstrateinhibitorDetails
DB00980Ramelteonapproved, investigationalunknownsubstrateDetails
DB01128BicalutamideapprovedunknowninhibitorDetails
DB01259Lapatinibapproved, investigationalunknownsubstrateDetails
DB01621Pipotiazineapproved, investigationalunknownsubstrateDetails
DB00918Almotriptanapproved, investigationalunknownsubstrateDetails
DB04920Clevidipineapproved, investigationalunknowninhibitorDetails
DB00109Enfuvirtideapproved, investigationalunknownsubstrateDetails
DB00239OxiconazoleapprovedunknownsubstrateDetails
DB00082PegvisomantapprovedunknownDetails
DB06204TapentadolapprovedunknownsubstrateDetails
DB06209PrasugrelapprovedyessubstrateDetails
DB04871LorcaserinapprovednosubstrateDetails
DB08864RilpivirineapprovedunknownsubstrateDetails
DB06605ApixabanapprovedunknownsubstrateDetails
DB06626Axitinibapproved, investigationalnosubstrateDetails
DB08828Vismodegibapproved, investigationalunknowninhibitorDetails
DB08899EnzalutamideapprovedunknowninducerDetails
DB08895Tofacitinibapproved, investigationalnosubstrateDetails
DB04938Ospemifeneapproved, investigationalunknownsubstrateDetails
DB00317Gefitinibapproved, investigationalunknowninhibitorDetails
DB08918Levomilnacipranapproved, investigationalunknownsubstrateDetails
DB08932MacitentanapprovednosubstrateDetails
DB08933LuliconazoleapprovednoinhibitorDetails
DB09049NaloxegolapprovedunknowninhibitorDetails
DB00951Isoniazidapproved, investigationalunknownDetails
DB09054IdelalisibapprovednoinhibitorDetails
DB09068Vortioxetineapproved, investigationalnosubstrateDetails
DB09280LumacaftorapprovednoinducerDetails
DB09570Ixazomibapproved, investigationalunknownsubstrateDetails
DB06176Romidepsinapproved, investigationalunknownsubstrateDetails
DB09119Eslicarbazepine acetateapprovedyesinhibitorDetails
DB06789Hydroxyprogesterone caproateapproved, investigationalunknowninducerDetails
DB05812AbirateroneapprovedunknowninhibitorDetails
DB09118StiripentolapprovedunknowninhibitorDetails
DB06595Midostaurinapproved, investigationalunknowninhibitorinducerDetails
DB05541Brivaracetamapproved, investigationalnosubstrateDetails
DB05351Dexlansoprazoleapproved, investigationalunknownsubstrateinhibitorDetails
DB01685TopiroxostatexperimentalunknowninhibitorDetails
DB09120Zucapsaicinapproved, investigationalunknowninhibitorDetails
DB09198LobeglitazoneexperimentalnoinhibitorDetails
DB09167DosulepinapprovedunknowninhibitorDetails
DB09166EtizolamexperimentalunknownsubstrateDetails
DB11614RupatadineapprovednosubstrateDetails
DB12319Benzbromaroneinvestigational, withdrawnunknowninhibitorDetails
DB09238Manidipineapproved, investigationalunknowninhibitorDetails
DB13874Enasidenibapproved, investigationalunknownsubstrateinhibitorDetails
DB12070Letermovirapproved, investigationalnoinducerDetails
DB12332Rucaparibapproved, investigationalunknowninhibitorDetails
DB09061Cannabidiolapproved, investigationalunknownsubstrateDetails
DB13943Testosterone cypionateapprovedunknownsubstrateDetails
DB13944Testosterone enanthateapprovedunknownsubstrateDetails
DB13946Testosterone undecanoateapproved, investigationalunknownsubstrateDetails
DB13952Estradiol acetateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13953Estradiol benzoateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13954Estradiol cypionateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13955Estradiol dienanthateapproved, investigational, vet_approvedunknownsubstrateDetails
DB13956Estradiol valerateapproved, investigational, vet_approvedunknownsubstrateDetails
DB11638Artenimolexperimental, investigationalunknowninhibitorDetails
DB13941Piperaquineexperimental, investigationalunknownsubstrateinhibitorDetails
DB11901Apalutamideapproved, investigationalunknowninducerDetails
DB11633Isavuconazoleapproved, investigationalunknowninhibitorDetails
DB11586Asunaprevirapproved, investigational, withdrawnnosubstrateDetails
DB14011NabiximolsinvestigationalunknownsubstrateDetails
DB14009Medical Cannabisexperimental, investigationalunknownsubstrateDetails
DB11632Opicaponeapproved, investigationalunknowninducerDetails
DB13746Bioallethrinapproved, experimentalnosubstrateDetails
DB04948Lofexidineapproved, investigationalnosubstrateDetails
DB00598LabetalolapprovedunknownsubstrateDetails
DB11967Binimetinibapproved, investigationalunknownsubstrateDetails
DB11718Encorafenibapproved, investigationalunknownsubstrateDetails
DB12474Lynestrenolapproved, investigationalnosubstrateDetails
DB00615Rifabutinapproved, investigationalnoinducerDetails
DB01201Rifapentineapproved, investigationalnoinducerDetails
DB01220Rifaximinapproved, investigationalnoinducerDetails
DB11753Rifamycinapproved, investigationalnoinducerDetails
DB01483BarbitalillicitnosubstrateinducerDetails
DB00474MethohexitalapprovednosubstrateDetails
DB00418Secobarbitalapproved, vet_approvednoinducerDetails
DB00599Thiopentalapproved, vet_approvednosubstrateDetails
DB06654Safinamideapproved, investigationalunknowninhibitorDetails
DB09078Lenvatinibapproved, investigationalunknowninhibitorDetails
DB05928DovitinibinvestigationalunknowninhibitorDetails
DB08496(R)-warfarinexperimentalunknownsubstrateDetails
DB14055(S)-Warfarinexperimental, investigationalunknownDetails
DB04911Oritavancinapproved, investigationalunknowninhibitorDetails
DB06218LacosamideapprovedunknownsubstrateDetails
DB12319Benzbromaroneinvestigational, withdrawnunknowninhibitorDetails
DB01223AminophyllineapprovedunknownDetails
DB09213Dexibuprofenapproved, investigationalunknownDetails
DB00518Albendazoleapproved, vet_approvednosubstrateDetails