1-phosphatidylinositol phosphodiesterase
Details
- Name
- 1-phosphatidylinositol phosphodiesterase
- Synonyms
- 4.6.1.13
- Phosphatidylinositol diacylglycerol-lyase
- Phosphatidylinositol-specific phospholipase C
- PI-PLC
- pic
- Gene Name
- plcA
- Organism
- Listeria monocytogenes serovar 1/2a (strain ATCC BAA-679 / EGD-e)
- Amino acid sequence
>lcl|BSEQ0012068|1-phosphatidylinositol phosphodiesterase MYKNYLQRTLVLLLCFILYFFTFPLGGKAYSLNNWNKPIKNSVTTKQWMSALPDTTNLAA LSIPGTHDTMSYNGDITWTLTKPLAQTQTMSLYQQLEAGIRYIDIRAKDNLNIYHGPIFL NASLSGVLETITQFLKKNPKETIIMRLKDEQNSNDSFDYRIQPLINIYKDYFYTTPRTDT SNKIPTLKDVRGKILLLSENHTKKPLVINSRKFGMQFGAPNQVIQDDYNGPSVKTKFKEI VQTAYQASKADNKLFLNHISATSLTFTPRQYAAALNNKVEQFVLNLTSEKVRGLGILIMD FPEKQTIKNIIKNNKFN
- Number of residues
- 317
- Molecular Weight
- 36317.61
- Theoretical pI
- 10.14
- GO Classification
- Functionsphosphatidylinositol diacylglycerol-lyase activity / phosphoric diester hydrolase activityProcesseslipid catabolic process / pathogenesisComponentscytoplasm / extracellular region
- General Function
- Phosphoric diester hydrolase activity
- Specific Function
- Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Important factor in pathogenesis, PI-PLC activity is present only in virulent listeria species. It may participate in the lysis of the phagolysosomal membrane.
- Pfam Domain Function
- PI-PLC-X (PF00388)
- Transmembrane Regions
- Not Available
- Cellular Location
- Secreted
- Gene sequence
>lcl|BSEQ0012069|1-phosphatidylinositol phosphodiesterase (plcA) TTGTATAAGAATTATTTGCAACGCACATTAGTTTTATTACTCTGTTTTATTTTATACTTT TTTACTTTCCCATTAGGCGGAAAAGCATATTCGCTTAATAACTGGAATAAGCCAATAAAG AACTCTGTAACTACAAAACAATGGATGTCCGCTCTACCTGACACAACAAACCTAGCAGCG CTCTCTATACCAGGTACACATGATACGATGAGCTATAACGGAGACATAACATGGACATTA ACCAAACCACTAGCTCAAACACAAACGATGTCATTGTACCAACAACTAGAAGCAGGAATA CGGTACATCGATATTAGAGCAAAAGACAATCTCAACATTTACCATGGGCCAATTTTTTTA AATGCATCACTTTCAGGTGTATTAGAAACGATTACTCAATTTTTAAAGAAAAATCCAAAA GAAACCATTATTATGCGTTTAAAAGACGAGCAAAACAGCAACGATAGTTTTGATTATCGG ATCCAACCACTAATCAACATTTATAAAGATTATTTTTACACTACTCCCAGAACTGACACG AGCAATAAAATCCCTACATTAAAAGATGTCCGCGGAAAAATATTATTACTTTCAGAGAAC CACACAAAAAAGCCATTAGTCATTAACTCACGCAAATTCGGCATGCAGTTCGGCGCACCT AACCAAGTAATTCAAGATGACTACAATGGTCCGAGTGTGAAAACAAAATTCAAAGAGATT GTCCAGACTGCTTATCAAGCTTCCAAAGCGGACAATAAACTTTTTCTTAACCATATTAGC GCCACTTCATTAACATTCACACCTCGTCAGTATGCTGCAGCATTAAACAACAAAGTAGAG CAATTCGTACTCAACTTAACATCGGAAAAAGTTCGAGGATTAGGCATACTAATCATGGAC TTCCCCGAAAAACAAACAATTAAAAACATCATAAAAAACAATAAATTCAACTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P34024 UniProtKB Entry Name PLC_LISMO GenBank Gene ID X54618 - General References
- Mengaud J, Braun-Breton C, Cossart P: Identification of phosphatidylinositol-specific phospholipase C activity in Listeria monocytogenes: a novel type of virulence factor? Mol Microbiol. 1991 Feb;5(2):367-72. [Article]
- Leimeister-Wachter M, Domann E, Chakraborty T: Detection of a gene encoding a phosphatidylinositol-specific phospholipase C that is co-ordinately expressed with listeriolysin in Listeria monocytogenes. Mol Microbiol. 1991 Feb;5(2):361-6. [Article]
- Glaser P, Frangeul L, Buchrieser C, Rusniok C, Amend A, Baquero F, Berche P, Bloecker H, Brandt P, Chakraborty T, Charbit A, Chetouani F, Couve E, de Daruvar A, Dehoux P, Domann E, Dominguez-Bernal G, Duchaud E, Durant L, Dussurget O, Entian KD, Fsihi H, Garcia-del Portillo F, Garrido P, Gautier L, Goebel W, Gomez-Lopez N, Hain T, Hauf J, Jackson D, Jones LM, Kaerst U, Kreft J, Kuhn M, Kunst F, Kurapkat G, Madueno E, Maitournam A, Vicente JM, Ng E, Nedjari H, Nordsiek G, Novella S, de Pablos B, Perez-Diaz JC, Purcell R, Remmel B, Rose M, Schlueter T, Simoes N, Tierrez A, Vazquez-Boland JA, Voss H, Wehland J, Cossart P: Comparative genomics of Listeria species. Science. 2001 Oct 26;294(5543):849-52. [Article]
- Mengaud J, Vicente MF, Cossart P: Transcriptional mapping and nucleotide sequence of the Listeria monocytogenes hlyA region reveal structural features that may be involved in regulation. Infect Immun. 1989 Dec;57(12):3695-701. [Article]
- Moser J, Gerstel B, Meyer JE, Chakraborty T, Wehland J, Heinz DW: Crystal structure of the phosphatidylinositol-specific phospholipase C from the human pathogen Listeria monocytogenes. J Mol Biol. 1997 Oct 17;273(1):269-82. [Article]