Catenin beta-1

Details

Name
Catenin beta-1
Synonyms
  • Beta-catenin
  • CTNNB
Gene Name
CTNNB1
Organism
Humans
Amino acid sequence
>lcl|BSEQ0001961|Catenin beta-1
MATQADLMELDMAMEPDRKAAVSHWQQQSYLDSGIHSGATTTAPSLSGKGNPEEEDVDTS
QVLYEWEQGFSQSFTQEQVADIDGQYAMTRAQRVRAAMFPETLDEGMQIPSTQFDAAHPT
NVQRLAEPSQMLKHAVVNLINYQDDAELATRAIPELTKLLNDEDQVVVNKAAVMVHQLSK
KEASRHAIMRSPQMVSAIVRTMQNTNDVETARCTAGTLHNLSHHREGLLAIFKSGGIPAL
VKMLGSPVDSVLFYAITTLHNLLLHQEGAKMAVRLAGGLQKMVALLNKTNVKFLAITTDC
LQILAYGNQESKLIILASGGPQALVNIMRTYTYEKLLWTTSRVLKVLSVCSSNKPAIVEA
GGMQALGLHLTDPSQRLVQNCLWTLRNLSDAATKQEGMEGLLGTLVQLLGSDDINVVTCA
AGILSNLTCNNYKNKMMVCQVGGIEALVRTVLRAGDREDITEPAICALRHLTSRHQEAEM
AQNAVRLHYGLPVVVKLLHPPSHWPLIKATVGLIRNLALCPANHAPLREQGAIPRLVQLL
VRAHQDTQRRTSMGGTQQQFVEGVRMEEIVEGCTGALHILARDVHNRIVIRGLNTIPLFV
QLLYSPIENIQRVAAGVLCELAQDKEAAEAIEAEGATAPLTELLHSRNEGVATYAAAVLF
RMSEDKPQDYKKRLSVELTSSLFRTEPMAWNETADLGLDIGAQGEPLGYRQDDPSYRSFH
SGGYGQDALGMDPMMEHEMGGHHPGADYPVDGLPDLGHAQDLMDGLPPGDSNQLAWFDTD
L
Number of residues
781
Molecular Weight
85495.94
Theoretical pI
5.71
GO Classification
Functions
alpha-catenin binding / androgen receptor binding / cadherin binding / double-stranded DNA binding / enzyme binding / estrogen receptor binding / euchromatin binding / I-SMAD binding / ion channel binding / kinase binding / nuclear hormone receptor binding / protein C-terminus binding / protein phosphatase binding / R-SMAD binding / RNA polymerase II activating transcription factor binding / signal transducer activity / SMAD binding / transcription coactivator activity / transcription factor activity, sequence-specific DNA binding / transcription factor binding / transcription regulatory region DNA binding
Processes
adherens junction assembly / androgen receptor signaling pathway / anterior/posterior axis specification / apoptotic process / bone resorption / branching involved in ureteric bud morphogenesis / canonical Wnt signaling pathway / canonical Wnt signaling pathway involved in negative regulation of apoptotic process / canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation / canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition / cell adhesion / cell fate specification / cell maturation / cell-matrix adhesion / cellular component disassembly involved in execution phase of apoptosis / cellular response to growth factor stimulus / cellular response to indole-3-methanol / central nervous system vasculogenesis / chromatin-mediated maintenance of transcription / dorsal/ventral axis specification / ectoderm development / embryonic axis specification / embryonic digit morphogenesis / embryonic foregut morphogenesis / embryonic forelimb morphogenesis / embryonic heart tube development / embryonic hindlimb morphogenesis / embryonic skeletal limb joint morphogenesis / endodermal cell fate commitment / endothelial tube morphogenesis / epithelial cell differentiation involved in prostate gland development / epithelial to mesenchymal transition / epithelial tube branching involved in lung morphogenesis / fungiform papilla formation / gastrulation with mouth forming second / genitalia morphogenesis / glial cell fate determination / hair cell differentiation / hair follicle morphogenesis / hair follicle placode formation / in utero embryonic development / innate immune response / layer formation in cerebral cortex / lens morphogenesis in camera-type eye / lung cell differentiation / lung induction / lung-associated mesenchyme development / male genitalia development / mesenchymal cell proliferation involved in lung development / mesenchymal to epithelial transition involved in metanephros morphogenesis / muscle cell differentiation / negative regulation of apoptotic signaling pathway / negative regulation of cell proliferation / negative regulation of chondrocyte differentiation / negative regulation of mitotic cell cycle, embryonic / negative regulation of neuron death / negative regulation of oligodendrocyte differentiation / negative regulation of osteoclast differentiation / negative regulation of protein sumoylation / negative regulation of transcription from RNA polymerase II promoter / negative regulation of transcription, DNA-templated / nephron tubule formation / neural plate development / neuron migration / odontogenesis of dentin-containing tooth / oocyte development / osteoclast differentiation / oviduct development / pancreas development / patterning of blood vessels / positive regulation of apoptotic process / positive regulation of canonical Wnt signaling pathway / positive regulation of determination of dorsal identity / positive regulation of DNA-templated transcription, initiation / positive regulation of endothelial cell differentiation / positive regulation of epithelial cell proliferation involved in prostate gland development / positive regulation of epithelial to mesenchymal transition / positive regulation of fibroblast growth factor receptor signaling pathway / positive regulation of heparan sulfate proteoglycan biosynthetic process / positive regulation of histone H3-K4 methylation / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of MAPK cascade / positive regulation of mesenchymal cell proliferation / positive regulation of muscle cell differentiation / positive regulation of neuroblast proliferation / positive regulation of neuron apoptotic process / positive regulation of osteoblast differentiation / positive regulation of skeletal muscle tissue development / positive regulation of telomerase activity / positive regulation of telomere maintenance via telomerase / positive regulation of transcription from RNA polymerase II promoter / positive regulation of transcription, DNA-templated / positive regulation of type I interferon production / programmed cell death / protein localization to cell surface / proximal/distal pattern formation / regulation of angiogenesis / regulation of calcium ion import / regulation of cell fate specification / regulation of centriole-centriole cohesion / regulation of centromeric sister chromatid cohesion / regulation of fibroblast proliferation / regulation of myelination / regulation of nephron tubule epithelial cell differentiation / regulation of protein localization to cell surface / regulation of secondary heart field cardioblast proliferation / regulation of smooth muscle cell proliferation / regulation of T cell proliferation / renal inner medulla development / renal outer medulla development / renal vesicle formation / response to drug / response to estradiol / single organismal cell-cell adhesion / small GTPase mediated signal transduction / smooth muscle cell differentiation / stem cell population maintenance / sympathetic ganglion development / synapse organization / synaptic transmission / synaptic vesicle transport / T cell differentiation in thymus / thymus development / trachea formation / transcription, DNA-templated / Wnt signaling pathway
Components
adherens junction / apical part of cell / basolateral plasma membrane / beta-catenin destruction complex / beta-catenin-TCF7L2 complex / bicellular tight junction / catenin complex / cell cortex / cell junction / cell periphery / cell-cell adherens junction / cell-cell junction / centrosome / cytoplasm / cytosol / extracellular exosome / fascia adherens / flotillin complex / focal adhesion / lamellipodium / lateral plasma membrane / membrane / microvillus membrane / nuclear euchromatin / nuclear transcription factor complex / nucleoplasm / nucleus / perinuclear region of cytoplasm / plasma membrane / protein complex / protein-DNA complex / Scrib-APC-beta-catenin complex / spindle pole / transcription factor complex / Z disc
General Function
Transcription regulatory region dna binding
Specific Function
Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22647378, PubMed:22699938, PubMed:22155184). Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle (By similarity).
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0010691|Catenin beta-1 (CTNNB1)
ATGGCTACTCAAGCTGATTTGATGGAGTTGGACATGGCCATGGAACCAGACAGAAAAGCG
GCTGTTAGTCACTGGCAGCAACAGTCTTACCTGGACTCTGGAATCCATTCTGGTGCCACT
ACCACAGCTCCTTCTCTGAGTGGTAAAGGCAATCCTGAGGAAGAGGATGTGGATACCTCC
CAAGTCCTGTATGAGTGGGAACAGGGATTTTCTCAGTCCTTCACTCAAGAACAAGTAGCT
GATATTGATGGACAGTATGCAATGACTCGAGCTCAGAGGGTACGAGCTGCTATGTTCCCT
GAGACATTAGATGAGGGCATGCAGATCCCATCTACACAGTTTGATGCTGCTCATCCCACT
AATGTCCAGCGTTTGGCTGAACCATCACAGATGCTGAAACATGCAGTTGTAAACTTGATT
AACTATCAAGATGATGCAGAACTTGCCACACGTGCAATCCCTGAACTGACAAAACTGCTA
AATGACGAGGACCAGGTGGTGGTTAATAAGGCTGCAGTTATGGTCCATCAGCTTTCTAAA
AAGGAAGCTTCCAGACACGCTATCATGCGTTCTCCTCAGATGGTGTCTGCTATTGTACGT
ACCATGCAGAATACAAATGATGTAGAAACAGCTCGTTGTACCGCTGGGACCTTGCATAAC
CTTTCCCATCATCGTGAGGGCTTACTGGCCATCTTTAAGTCTGGAGGCATTCCTGCCCTG
GTGAAAATGCTTGGTTCACCAGTGGATTCTGTGTTGTTTTATGCCATTACAACTCTCCAC
AACCTTTTATTACATCAAGAAGGAGCTAAAATGGCAGTGCGTTTAGCTGGTGGGCTGCAG
AAAATGGTTGCCTTGCTCAACAAAACAAATGTTAAATTCTTGGCTATTACGACAGACTGC
CTTCAAATTTTAGCTTATGGCAACCAAGAAAGCAAGCTCATCATACTGGCTAGTGGTGGA
CCCCAAGCTTTAGTAAATATAATGAGGACCTATACTTACGAAAAACTACTGTGGACCACA
AGCAGAGTGCTGAAGGTGCTATCTGTCTGCTCTAGTAATAAGCCGGCTATTGTAGAAGCT
GGTGGAATGCAAGCTTTAGGACTTCACCTGACAGATCCAAGTCAACGTCTTGTTCAGAAC
TGTCTTTGGACTCTCAGGAATCTTTCAGATGCTGCAACTAAACAGGAAGGGATGGAAGGT
CTCCTTGGGACTCTTGTTCAGCTTCTGGGTTCAGATGATATAAATGTGGTCACCTGTGCA
GCTGGAATTCTTTCTAACCTCACTTGCAATAATTATAAGAACAAGATGATGGTCTGCCAA
GTGGGTGGTATAGAGGCTCTTGTGCGTACTGTCCTTCGGGCTGGTGACAGGGAAGACATC
ACTGAGCCTGCCATCTGTGCTCTTCGTCATCTGACCAGCCGACACCAAGAAGCAGAGATG
GCCCAGAATGCAGTTCGCCTTCACTATGGACTACCAGTTGTGGTTAAGCTCTTACACCCA
CCATCCCACTGGCCTCTGATAAAGGCTACTGTTGGATTGATTCGAAATCTTGCCCTTTGT
CCCGCAAATCATGCACCTTTGCGTGAGCAGGGTGCCATTCCACGACTAGTTCAGTTGCTT
GTTCGTGCACATCAGGATACCCAGCGCCGTACGTCCATGGGTGGGACACAGCAGCAATTT
GTGGAGGGGGTCCGCATGGAAGAAATAGTTGAAGGTTGTACCGGAGCCCTTCACATCCTA
GCTCGGGATGTTCACAACCGAATTGTTATCAGAGGACTAAATACCATTCCATTGTTTGTG
CAGCTGCTTTATTCTCCCATTGAAAACATCCAAAGAGTAGCTGCAGGGGTCCTCTGTGAA
CTTGCTCAGGACAAGGAAGCTGCAGAAGCTATTGAAGCTGAGGGAGCCACAGCTCCTCTG
ACAGAGTTACTTCACTCTAGGAATGAAGGTGTGGCGACATATGCAGCTGCTGTTTTGTTC
CGAATGTCTGAGGACAAGCCACAAGATTACAAGAAACGGCTTTCAGTTGAGCTGACCAGC
TCTCTCTTCAGAACAGAGCCAATGGCTTGGAATGAGACTGCTGATCTTGGACTTGATATT
GGTGCCCAGGGAGAACCCCTTGGATATCGCCAGGATGATCCTAGCTATCGTTCTTTTCAC
TCTGGTGGATATGGCCAGGATGCCTTGGGTATGGACCCCATGATGGAACATGAGATGGGT
GGCCACCACCCTGGTGCTGACTATCCAGTTGATGGGCTGCCAGATCTGGGGCATGCCCAG
GACCTCATGGATGGGCTGCCTCCAGGTGACAGCAATCAGCTGGCCTGGTTTGATACTGAC
CTGTAA
Chromosome Location
3
Locus
3p21
External Identifiers
ResourceLink
UniProtKB IDP35222
UniProtKB Entry NameCTNB1_HUMAN
GenBank Protein ID860988
GenBank Gene IDX87838
GenAtlas IDCTNNB1
HGNC IDHGNC:2514
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03904Ureaapproved, investigationalunknownDetails