Recoverin
Details
- Name
- Recoverin
- Synonyms
- Cancer-associated retinopathy protein
- Protein CAR
- RCV1
- Gene Name
- RCVRN
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0017377|Recoverin MGNSKSGALSKEILEELQLNTKFSEEELCSWYQSFLKDCPTGRITQQQFQSIYAKFFPDT DPKAYAQHVFRSFDSNLDGTLDFKEYVIALHMTTAGKTNQKLEWAFSLYDVDGNGTISKN EVLEIVMAIFKMITPEDVKLLPDDENTPEKRAEKIWKYFGKNDDDKLTEKEFIEGTLANK EILRLIQFEPQKVKEKMKNA
- Number of residues
- 200
- Molecular Weight
- 23130.085
- Theoretical pI
- 4.79
- GO Classification
- Functionscalcium ion binding / calcium sensitive guanylate cyclase activator activityProcessesphototransduction, visible light / positive regulation of guanylate cyclase activity / regulation of calcium ion transport / regulation of rhodopsin mediated signaling pathway / rhodopsin mediated signaling pathway / signal transduction / visual perception
- General Function
- Calcium sensitive guanylate cyclase activator activity
- Specific Function
- Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse.
- Pfam Domain Function
- Transmembrane Regions
- Not Available
- Cellular Location
- Not Available
- Gene sequence
>lcl|BSEQ0017378|Recoverin (RCVRN) ATGGGGAACAGCAAAAGTGGGGCCCTGTCCAAGGAGATCCTGGAGGAGCTGCAGCTGAAC ACCAAGTTCTCGGAGGAGGAGCTGTGCTCCTGGTACCAGTCCTTCCTGAAGGACTGTCCC ACCGGCCGCATCACCCAGCAGCAGTTCCAGAGCATCTACGCCAAGTTCTTCCCCGACACC GACCCCAAGGCCTACGCCCAGCATGTGTTCCGCAGCTTCGATTCCAACCTCGACGGCACC CTGGACTTCAAGGAGTACGTCATCGCCCTGCACATGACCACCGCGGGCAAGACCAACCAG AAGCTGGAGTGGGCCTTCTCCCTCTACGACGTGGACGGTAACGGGACCATCAGCAAGAAT GAAGTGCTGGAGATCGTCATGGCTATTTTCAAAATGATCACTCCCGAGGACGTGAAGCTC CTTCCAGACGATGAAAACACGCCGGAAAAGCGAGCCGAGAAGATCTGGAAGTACTTTGGA AAGAATGATGATGATAAACTTACAGAGAAAGAATTCATTGAGGGGACACTGGCCAATAAG GAAATTCTGCGACTGATCCAGTTTGAGCCTCAAAAAGTGAAGGAAAAGATGAAGAACGCC TGA
- Chromosome Location
- 17
- Locus
- 17p13.1
- External Identifiers
Resource Link UniProtKB ID P35243 UniProtKB Entry Name RECO_HUMAN GenBank Protein ID 255059 GenBank Gene ID S43855 HGNC ID HGNC:9937 - General References
- Murakami A, Yajima T, Inana G: Isolation of human retinal genes: recoverin cDNA and gene. Biochem Biophys Res Commun. 1992 Aug 31;187(1):234-44. [Article]
- Wiechmann AF, Hammarback JA: Molecular cloning and nucleotide sequence of a cDNA encoding recoverin from human retina. Exp Eye Res. 1993 Apr;56(4):463-70. [Article]
- Thirkill CE, Tait RC, Tyler NK, Roth AM, Keltner JL: The cancer-associated retinopathy antigen is a recoverin-like protein. Invest Ophthalmol Vis Sci. 1992 Sep;33(10):2768-72. [Article]
- Matsubara S, Yamaji Y, Sato M, Fujita J, Takahara J: Expression of a photoreceptor protein, recoverin, as a cancer-associated retinopathy autoantigen in human lung cancer cell lines. Br J Cancer. 1996 Nov;74(9):1419-22. [Article]
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