50S ribosomal protein L4

Details

Name
50S ribosomal protein L4
Synonyms
  • TmaL4
Gene Name
rplD
Organism
Thermotoga maritima (strain ATCC 43589 / MSB8 / DSM 3109 / JCM 10099)
Amino acid sequence
>lcl|BSEQ0012268|50S ribosomal protein L4
MAQVDLLNVKGEKVGTLEISDFVFNIDPNYDVMWRYVDMQLSNRRAGTASTKTRGEVSGG
GRKPWPQKHTGRARHGSIRSPIWRHGGVVHGPKPRDWSKKLNKKMKKLALRSALSVKYRE
NKLLVLDDLKLERPKTKSLKEILQNLQLSDKKTLIVLPWKEEGYMNVKLSGRNLPDVKVI
IADNPNNSKNGEKAVRIDGLNVFDMLKYDYLVLTRDMVSKIEEVLGNEAGKALTA
Number of residues
235
Molecular Weight
26630.77
Theoretical pI
10.62
GO Classification
Functions
rRNA binding / structural constituent of ribosome
Processes
translation
Components
ribosome
General Function
Structural constituent of ribosome
Specific Function
One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).This protein only weakly controls expression of the E.coli S10 operon. It is incorporated into E.coli ribosomes, however it is not as firmly associated as the endogenous protein.Forms part of the polypeptide exit tunnel.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Not Available
Gene sequence
>lcl|BSEQ0012269|50S ribosomal protein L4 (rplD)
ATGGCTCAGGTTGATCTGTTGAATGTGAAGGGAGAAAAAGTAGGGACCCTGGAAATCAGT
GATTTCGTTTTCAACATCGATCCCAACTACGACGTGATGTGGAGATACGTGGATATGCAG
CTCTCCAACAGGAGAGCTGGAACTGCCTCTACGAAAACAAGAGGAGAAGTCTCCGGTGGT
GGCAGAAAACCCTGGCCGCAGAAACACACTGGAAGAGCAAGACACGGATCCATAAGATCT
CCCATCTGGAGACATGGAGGAGTAGTACACGGACCTAAACCGAGAGATTGGAGCAAAAAG
CTCAACAAAAAAATGAAGAAACTCGCTTTGCGATCTGCCCTTTCTGTGAAGTACAGAGAA
AACAAACTCCTTGTACTCGATGATCTGAAACTCGAAAGACCCAAGACAAAGTCTCTGAAG
GAAATTCTCCAGAACCTTCAGCTTTCCGACAAGAAAACACTGATTGTCCTTCCGTGGAAA
GAGGAAGGATATATGAATGTGAAACTCTCTGGAAGAAACCTTCCCGACGTGAAGGTAATA
ATTGCGGACAATCCGAACAACAGCAAAAATGGTGAGAAGGCGGTAAGAATAGATGGACTC
AATGTTTTTGACATGCTCAAGTACGATTACCTTGTTCTCACCAGGGACATGGTTTCCAAG
ATAGAGGAGGTGCTCGGAAATGAAGCAGGAAAAGCTCTCACTGCATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP38516
UniProtKB Entry NameRL4_THEMA
GenBank Gene IDZ21677
General References
  1. Sanangelantoni AM, Bocchetta M, Cammarano P, Tiboni O: Phylogenetic depth of S10 and spc operons: cloning and sequencing of a ribosomal protein gene cluster from the extremely thermophilic bacterium Thermotoga maritima. J Bacteriol. 1994 Dec;176(24):7703-10. [Article]
  2. Nelson KE, Clayton RA, Gill SR, Gwinn ML, Dodson RJ, Haft DH, Hickey EK, Peterson JD, Nelson WC, Ketchum KA, McDonald L, Utterback TR, Malek JA, Linher KD, Garrett MM, Stewart AM, Cotton MD, Pratt MS, Phillips CA, Richardson D, Heidelberg J, Sutton GG, Fleischmann RD, Eisen JA, White O, Salzberg SL, Smith HO, Venter JC, Fraser CM: Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritima. Nature. 1999 May 27;399(6734):323-9. [Article]
  3. Worbs M, Wahl MC, Lindahl L, Zengel JM: Comparative anatomy of a regulatory ribosomal protein. Biochimie. 2002 Aug;84(8):731-43. [Article]
  4. Worbs M, Huber R, Wahl MC: Crystal structure of ribosomal protein L4 shows RNA-binding sites for ribosome incorporation and feedback control of the S10 operon. EMBO J. 2000 Mar 1;19(5):807-18. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB04272Citric acidapproved, nutraceutical, vet_approvedunknownDetails