2,3-dihydroxybenzoate-AMP ligase

Details

Name
2,3-dihydroxybenzoate-AMP ligase
Synonyms
  • 6.3.2.-
  • Dihydroxybenzoic acid-activating enzyme
  • entE
Gene Name
dhbE
Organism
Bacillus subtilis (strain 168)
Amino acid sequence
>lcl|BSEQ0019081|2,3-dihydroxybenzoate-AMP ligase
MLKGFTPWPDELAETYRKNGCWAGETFGDLLRDRAAKYGDRIAITCGNTHWSYRELDTRA
DRLAAGFQKLGIQQMDRVVVQLPNIKEFFEVIFALFRLGALPVFALPSHRSSEITYFCEF
AEAAAYIIPDAYSGFDYRSLARQVQSKLPTLKNIIVAGEAEEFLPLEDLHAEPVKLPEVK
SSDVAFLQLSGGSTGLSKLIPRTHDDYIYSLKRSVEVCWLDHSTVYLAALPMAHNYPLSS
PGVLGVLYAGGRVVLSPSPSPDDAFPLIEREKVTITALVPPLAMVWMDAASSRRDDLSSL
QVLQVGGAKFSAEAARRVKAVFGCTLQQVFGMAEGLVNYTRLDDPEEIIVNTQGKPMSPY
DEMRVWDDHDRDVKPGETGHLLTRGPYTIRGYYKAEEHNAASFTEDGFYRTGDIVRLTRD
GYIVVEGRAKDQINRGGEKVAAEEVENHLLAHPAVHDAAMVSMPDQFLGERSCVFIIPRD
EAPKAAELKAFLRERGLAAYKIPDRVEFVESFPQTGVGKVSKKALREAISEKLLAGFKK
Number of residues
539
Molecular Weight
59927.77
Theoretical pI
5.98
GO Classification
Functions
(2,3-dihydroxybenzoyl)adenylate synthase activity / ATP binding / ligase activity
Processes
siderophore biosynthetic process
Components
cytoplasm
General Function
Ligase activity
Specific Function
Activation of the carboxylate group of 2,3-dihydroxy-benzoate (DHB), via ATP-dependent PPi exchange reactions, to the acyladenylate.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0019082|2,3-dihydroxybenzoate-AMP ligase (dhbE)
ATGCTGAAAGGATTTACGCCTTGGCCTGATGAGTTAGCTGAGACCTATCGAAAGAACGGC
TGCTGGGCCGGTGAGACGTTTGGAGATTTGTTAAGGGACCGGGCAGCCAAATATGGTGAT
CGCATTGCCATTACATGCGGAAACACCCATTGGAGCTATCGAGAGCTTGACACAAGGGCT
GATCGCCTGGCTGCCGGATTTCAAAAGCTCGGCATTCAACAGATGGATCGTGTTGTGGTG
CAGTTGCCAAATATCAAAGAGTTTTTTGAAGTCATTTTCGCGCTTTTCCGTCTGGGGGCG
CTTCCAGTCTTCGCACTGCCTTCTCATCGAAGCAGTGAAATTACATATTTTTGCGAGTTT
GCTGAAGCGGCTGCATATATCATTCCCGACGCTTATTCCGGTTTTGACTACCGTTCGCTT
GCCAGACAGGTTCAAAGCAAGCTGCCGACTTTGAAAAACATCATTGTCGCAGGTGAGGCA
GAGGAATTTTTACCGCTGGAGGATTTGCATGCAGAACCTGTAAAACTGCCTGAAGTCAAA
TCATCGGATGTGGCGTTCCTCCAGCTTTCTGGCGGGAGCACCGGGCTATCGAAACTGATT
CCGAGGACCCACGATGACTACATATACAGCCTGAAGCGGAGTGTGGAGGTCTGCTGGCTC
GACCACAGCACGGTGTACTTGGCCGCGCTGCCGATGGCACACAATTATCCGCTGAGCTCA
CCCGGCGTTCTCGGCGTATTATACGCTGGAGGAAGAGTGGTATTATCTCCTTCTCCAAGT
CCAGATGACGCATTTCCTTTAATTGAACGGGAAAAGGTCACGATAACCGCTCTTGTTCCG
CCTCTTGCGATGGTATGGATGGATGCGGCATCCTCACGCCGTGATGATTTATCCAGCCTT
CAAGTGCTGCAGGTCGGCGGTGCCAAGTTTAGTGCTGAAGCCGCGCGCAGGGTAAAAGCT
GTTTTCGGCTGCACGCTGCAGCAGGTGTTCGGAATGGCAGAGGGTCTCGTCAATTATACG
AGATTGGATGATCCTGAGGAGATCATTGTCAACACCCAAGGAAAACCGATGTCTCCATAT
GATGAAATGCGTGTTTGGGATGATCATGATCGCGACGTAAAACCTGGTGAAACAGGCCAT
CTGCTGACGCGGGGGCCGTATACAATTCGAGGTTACTATAAGGCAGAAGAGCATAACGCC
GCTTCATTTACTGAGGACGGTTTTTACCGTACGGGTGATATCGTCAGGCTGACACGAGAC
GGCTATATTGTCGTTGAAGGCCGGGCGAAGGATCAAATTAACCGTGGAGGAGAAAAGGTT
GCGGCTGAAGAGGTAGAAAATCATCTGCTGGCGCATCCGGCTGTCCATGATGCGGCAATG
GTCTCCATGCCTGATCAATTTCTTGGCGAAAGATCTTGTGTGTTCATTATTCCCCGGGAT
GAAGCCCCAAAAGCCGCAGAGCTTAAAGCATTTTTGAGAGAGCGCGGACTGGCGGCATAT
AAAATCCCTGATCGAGTTGAATTTGTCGAATCCTTCCCGCAGACAGGAGTAGGAAAAGTC
AGCAAAAAAGCGCTCCGTGAAGCCATTTCCGAGAAGCTTCTTGCAGGATTTAAAAAATAA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP40871
UniProtKB Entry NameDHBE_BACSU
GenBank Protein ID837332
GenBank Gene IDU26444
General References
  1. Rowland BM, Grossman TH, Osburne MS, Taber HW: Sequence and genetic organization of a Bacillus subtilis operon encoding 2,3-dihydroxybenzoate biosynthetic enzymes. Gene. 1996 Oct 31;178(1-2):119-23. [Article]
  2. Kunst F, Ogasawara N, Moszer I, Albertini AM, Alloni G, Azevedo V, Bertero MG, Bessieres P, Bolotin A, Borchert S, Borriss R, Boursier L, Brans A, Braun M, Brignell SC, Bron S, Brouillet S, Bruschi CV, Caldwell B, Capuano V, Carter NM, Choi SK, Cordani JJ, Connerton IF, Cummings NJ, Daniel RA, Denziot F, Devine KM, Dusterhoft A, Ehrlich SD, Emmerson PT, Entian KD, Errington J, Fabret C, Ferrari E, Foulger D, Fritz C, Fujita M, Fujita Y, Fuma S, Galizzi A, Galleron N, Ghim SY, Glaser P, Goffeau A, Golightly EJ, Grandi G, Guiseppi G, Guy BJ, Haga K, Haiech J, Harwood CR, Henaut A, Hilbert H, Holsappel S, Hosono S, Hullo MF, Itaya M, Jones L, Joris B, Karamata D, Kasahara Y, Klaerr-Blanchard M, Klein C, Kobayashi Y, Koetter P, Koningstein G, Krogh S, Kumano M, Kurita K, Lapidus A, Lardinois S, Lauber J, Lazarevic V, Lee SM, Levine A, Liu H, Masuda S, Mauel C, Medigue C, Medina N, Mellado RP, Mizuno M, Moestl D, Nakai S, Noback M, Noone D, O'Reilly M, Ogawa K, Ogiwara A, Oudega B, Park SH, Parro V, Pohl TM, Portelle D, Porwollik S, Prescott AM, Presecan E, Pujic P, Purnelle B, Rapoport G, Rey M, Reynolds S, Rieger M, Rivolta C, Rocha E, Roche B, Rose M, Sadaie Y, Sato T, Scanlan E, Schleich S, Schroeter R, Scoffone F, Sekiguchi J, Sekowska A, Seror SJ, Serror P, Shin BS, Soldo B, Sorokin A, Tacconi E, Takagi T, Takahashi H, Takemaru K, Takeuchi M, Tamakoshi A, Tanaka T, Terpstra P, Togoni A, Tosato V, Uchiyama S, Vandebol M, Vannier F, Vassarotti A, Viari A, Wambutt R, Wedler H, Weitzenegger T, Winters P, Wipat A, Yamamoto H, Yamane K, Yasumoto K, Yata K, Yoshida K, Yoshikawa HF, Zumstein E, Yoshikawa H, Danchin A: The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Nature. 1997 Nov 20;390(6657):249-56. [Article]
  3. Adams R, Schumann W: Cloning and mapping of the Bacillus subtilis locus homologous to Escherichia coli ent genes. Gene. 1993 Oct 29;133(1):119-21. [Article]
  4. May JJ, Kessler N, Marahiel MA, Stubbs MT: Crystal structure of DhbE, an archetype for aryl acid activating domains of modular nonribosomal peptide synthetases. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12120-5. Epub 2002 Sep 9. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB016722,3-Dihydroxy-Benzoic AcidexperimentalunknownDetails