5-hydroxytryptamine receptor 2B

Details

Name
5-hydroxytryptamine receptor 2B
Synonyms
  • 5-HT-2B
  • Serotonin receptor 2B
Gene Name
HTR2B
Organism
Humans
Amino acid sequence
>lcl|BSEQ0016078|5-hydroxytryptamine receptor 2B
MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALL
ILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAM
WPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVW
LISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLT
IHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDET
LMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQM
LLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNP
MAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSY
V
Number of residues
481
Molecular Weight
54297.41
Theoretical pI
9.47
GO Classification
Functions
drug binding / G-protein alpha-subunit binding / GTPase activator activity / serotonin binding / serotonin receptor activity
Processes
activation of phospholipase C activity / behavior / calcium-mediated signaling / cardiac muscle hypertrophy / cellular calcium ion homeostasis / cellular response to amine stimulus / cellular response to serotonin / cellular response to temperature stimulus / cGMP biosynthetic process / embryonic morphogenesis / ERK1 and ERK2 cascade / G-protein coupled receptor internalization / G-protein coupled receptor signaling pathway / heart morphogenesis / hepatic stellate cell activation / inositol phosphate metabolic process / intestine smooth muscle contraction / ion transmembrane transport / negative regulation of apoptotic process / negative regulation of autophagy / negative regulation of cell death / neural crest cell differentiation / neural crest cell migration / phosphatidylinositol 3-kinase signaling / phosphorylation / positive regulation of cell division / positive regulation of cell proliferation / positive regulation of cytokine production / positive regulation of cytokine secretion / positive regulation of endothelial cell proliferation / positive regulation of ERK1 and ERK2 cascade / positive regulation of I-kappaB kinase/NF-kappaB signaling / positive regulation of MAP kinase activity / positive regulation of nitric-oxide synthase activity / positive regulation of phosphatidylinositol biosynthetic process / protein kinase C signaling / protein kinase C-activating G-protein coupled receptor signaling pathway / regulation of behavior / release of sequestered calcium ion into cytosol / response to drug / serotonin receptor signaling pathway / vasoconstriction
Components
cell junction / cytoplasm / dendrite / integral component of plasma membrane / neuronal cell body / plasma membrane / synapse
General Function
Serotonin receptor activity
Specific Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.
Pfam Domain Function
Transmembrane Regions
57-79 91-113 130-151 172-192 217-239 325-345 361-382
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0016079|5-hydroxytryptamine receptor 2B (HTR2B)
ATGGCTCTCTCTTACAGAGTGTCTGAACTTCAAAGCACAATTCCTGAGCACATTTTGCAG
AGCACCTTTGTTCACGTTATCTCTTCTAACTGGTCTGGATTACAGACAGAATCAATACCA
GAGGAAATGAAACAGATTGTTGAGGAACAGGGAAATAAACTGCACTGGGCAGCTCTTCTG
ATACTCATGGTGATAATACCCACAATTGGTGGAAATACCCTTGTTATTCTGGCTGTTTCA
CTGGAGAAGAAGCTGCAGTATGCTACTAATTACTTTCTAATGTCCTTGGCGGTGGCTGAT
TTGCTGGTTGGATTGTTTGTGATGCCAATTGCCCTCTTGACAATAATGTTTGAGGCTATG
TGGCCCCTCCCACTTGTTCTATGTCCTGCCTGGTTATTTCTTGACGTTCTCTTTTCAACC
GCATCCATCATGCATCTCTGTGCCATTTCAGTGGATCGTTACATAGCCATCAAAAAGCCA
ATCCAGGCCAATCAATATAACTCACGGGCTACAGCATTCATCAAGATTACAGTGGTGTGG
TTAATTTCAATAGGCATTGCCATTCCAGTCCCTATTAAAGGGATAGAGACTGATGTGGAC
AACCCAAACAATATCACTTGTGTGCTGACAAAGGAACGTTTTGGCGATTTCATGCTCTTT
GGCTCACTGGCTGCCTTCTTCACACCTCTTGCAATTATGATTGTCACCTACTTTCTCACT
ATCCATGCTTTACAGAAGAAGGCTTACTTAGTCAAAAACAAGCCACCTCAACGCCTAACA
TGGTTGACTGTGTCTACAGTTTTCCAAAGGGATGAAACACCTTGCTCGTCACCGGAAAAG
GTGGCAATGCTGGATGGTTCTCGAAAGGACAAGGCTCTGCCCAACTCAGGTGATGAAACA
CTTATGCGAAGAACATCCACAATTGGGAAAAAGTCAGTGCAGACCATTTCCAACGAACAG
AGAGCCTCAAAGGTCCTAGGGATTGTGTTTTTCCTCTTTTTGCTTATGTGGTGTCCCTTC
TTTATTACAAATATAACTTTAGTTTTATGTGATTCCTGTAACCAAACTACTCTCCAAATG
CTCCTGGAGATATTTGTGTGGATAGGCTATGTTTCCTCAGGAGTGAATCCTTTGGTCTAC
ACCCTCTTCAATAAGACATTTCGGGATGCATTTGGCCGATATATCACCTGCAATTACCGG
GCCACAAAGTCAGTAAAAACTCTCAGAAAACGCTCCAGTAAGATCTACTTCCGGAATCCA
ATGGCAGAGAACTCTAAGTTTTTCAAGAAACATGGAATTCGAAATGGGATTAACCCTGCC
ATGTACCAGAGTCCAATGAGGCTCCGAAGTTCAACCATTCAGTCTTCATCAATCATTCTA
CTAGATACGCTTCTCCTCACTGAAAATGAAGGTGACAAAACTGAAGAGCAAGTTAGTTAT
GTATAG
Chromosome Location
2
Locus
2q36.3-q37.1
External Identifiers
ResourceLink
UniProtKB IDP41595
UniProtKB Entry Name5HT2B_HUMAN
GenBank Protein ID475198
GenBank Gene IDX77307
GenAtlas IDHTR2B
HGNC IDHGNC:5294
General References
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  3. Kursar JD, Nelson DL, Wainscott DB, Baez M: Molecular cloning, functional expression, and mRNA tissue distribution of the human 5-hydroxytryptamine2B receptor. Mol Pharmacol. 1994 Aug;46(2):227-34. [Article]
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  9. Becamel C, Figge A, Poliak S, Dumuis A, Peles E, Bockaert J, Lubbert H, Ullmer C: Interaction of serotonin 5-hydroxytryptamine type 2C receptors with PDZ10 of the multi-PDZ domain protein MUPP1. J Biol Chem. 2001 Apr 20;276(16):12974-82. Epub 2001 Jan 9. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00508Triflupromazineapproved, vet_approvedyesantagonistDetails
DB00805MinaprineapprovedyesantagonistDetails
DB00574Fenfluramineapproved, illicit, investigational, withdrawnnoagonistDetails
DB01079Tegaserodapproved, investigational, withdrawnunknownantagonistDetails
DB05461OPC-28326investigationalunknownDetails
DB05492Epicept NP-1investigationalunknownDetails
DB06216AsenapineapprovedunknownantagonistDetails
DB06229OcaperidoneinvestigationalunknownDetails
DB01186Pergolideapproved, investigational, vet_approved, withdrawnunknownagonistDetails
DB01200Bromocriptineapproved, investigational, withdrawnunknownagonistDetails
DB00589Lisurideapproved, investigationalunknownantagonistDetails
DB00248CabergolineapprovedunknownagonistDetails
DB00714Apomorphineapproved, investigationalunknownagonistDetails
DB00247MethysergideapprovedyesantagonistDetails
DB00320Dihydroergotamineapproved, investigationalunknownagonistDetails
DB01242Clomipramineapproved, investigational, vet_approvedyesantagonistDetails
DB01142Doxepinapproved, investigationalunknownantagonistDetails
DB01454Midomafetamineexperimental, illicit, investigationalunknownagonistDetails
DB01392Yohimbineapproved, investigational, vet_approvedunknownantagonistDetails
DB00543AmoxapineapprovedunknownantagonistDetails
DB06148Mianserinapproved, investigationalunknownbinderDetails
DB00696ErgotamineapprovedunknownDetails
DB00353MethylergometrineapprovedunknownDetails
DB04829Lysergic acid diethylamideillicit, investigational, withdrawnunknownagonistDetails
DB09286PipamperoneinvestigationalunknownDetails
DB06153PizotifenapprovedunknownantagonistDetails
DB05607PRX-08066investigationalunknownantagonistDetails
DB00715Paroxetineapproved, investigationalunknownagonistDetails
DB00924CyclobenzaprineapprovedunknownantagonistDetails
DB01238Aripiprazoleapproved, investigationalunknowninverse agonistDetails
DB00315Zolmitriptanapproved, investigationalnoagonistDetails
DB00434CyproheptadineapprovedunknownantagonistDetails
DB06016Cariprazineapproved, investigationalunknownantagonistDetails
DB09185Viloxazineapproved, investigational, withdrawnyesantagonistDetails
DB09128Brexpiprazoleapproved, investigationalunknownantagonistDetails
DB13025TiaprideinvestigationalyesantagonistDetails
DB09304SetiptilineexperimentalunknownantagonistDetails
DB13345Dihydroergocristineapproved, experimentalyesantagonistDetails
DB01049Ergoloid mesylateapprovedyesantagonistagonistDetails
DB11273DihydroergocornineapprovedyesantagonistagonistDetails
DB12141Gilteritinibapproved, investigationalnoinhibitorDetails
DB00715Paroxetineapproved, investigationalunknownDetails
DB01239Chlorprothixeneapproved, experimental, investigational, withdrawnyesinhibitorDetails
DB00477Chlorpromazineapproved, investigational, vet_approvedunknownbinderDetails
DB08804Nandrolone decanoateapproved, illicitunknownmodulatorDetails
DB01221Ketamineapproved, vet_approvedunknownantagonistDetails
DB06678Esmirtazapineinvestigationalunknowninverse agonistDetails