C-C chemokine receptor type 2
Details
- Name
- C-C chemokine receptor type 2
- Synonyms
- C-C CKR-2
- CMKBR2
- MCP-1-R
- Monocyte chemoattractant protein 1 receptor
- Gene Name
- CCR2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0006609|C-C chemokine receptor type 2 MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGN MLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLY HIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTK CQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHR AVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCI NPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSI GRAPEASLQDKEGA
- Number of residues
- 374
- Molecular Weight
- 41914.265
- Theoretical pI
- 9.25
- GO Classification
- FunctionsC-C chemokine receptor activity / CCR2 chemokine receptor binding / chemokine receptor activity / protein homodimerization activityProcessesblood vessel remodeling / cellular calcium ion homeostasis / cellular defense response / cellular homeostasis / chemokine-mediated signaling pathway / chemotaxis / cytokine-mediated signaling pathway / dendritic cell chemotaxis / immune response / inflammatory response / innate immune response / JAK-STAT cascade / negative regulation of adenylate cyclase activity / negative regulation of angiogenesis / negative regulation of eosinophil degranulation / negative regulation of type 2 immune response / positive regulation of alpha-beta T cell proliferation / positive regulation of astrocyte chemotaxis / positive regulation of CD8-positive, alpha-beta T cell extravasation / positive regulation of cytosolic calcium ion concentration / positive regulation of hematopoietic stem cell migration / positive regulation of immune complex clearance by monocytes and macrophages / positive regulation of inflammatory response / positive regulation of interferon-gamma production / positive regulation of interleukin-2 production / positive regulation of monocyte chemotaxis / positive regulation of monocyte extravasation / positive regulation of T cell activation / positive regulation of T cell chemotaxis / positive regulation of T-helper 1 type immune response / positive regulation of tumor necrosis factor biosynthetic process / regulation of vascular endothelial growth factor production / response to wounding / T-helper 17 cell chemotaxis / viral processComponentscytoplasm / cytosol / dendrite / integral component of membrane / integral component of plasma membrane / neuronal cell body / perikaryon / perinuclear region of cytoplasm / plasma membrane
- General Function
- Protein homodimerization activity
- Specific Function
- Receptor for the CCL2, CCL7 and CCL13 chemokines. Transduces a signal by increasing intracellular calcium ion levels. Alternative coreceptor with CD4 for HIV-1 infection.
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 43-70 81-100 115-136 154-178 207-226 244-268 286-309
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0017084|C-C chemokine receptor type 2 (CCR2) ATGCTGTCCACATCTCGTTCTCGGTTTATCAGAAATACCAACGAGAGCGGTGAAGAAGTC ACCACCTTTTTTGATTATGATTACGGTGCTCCCTGTCATAAATTTGACGTGAAGCAAATT GGGGCCCAACTCCTGCCTCCGCTCTACTCGCTGGTGTTCATCTTTGGTTTTGTGGGCAAC ATGCTGGTCGTCCTCATCTTAATAAACTGCAAAAAGCTGAAGTGCTTGACTGACATTTAC CTGCTCAACCTGGCCATCTCTGATCTGCTTTTTCTTATTACTCTCCCATTGTGGGCTCAC TCTGCTGCAAATGAGTGGGTCTTTGGGAATGCAATGTGCAAATTATTCACAGGGCTGTAT CACATCGGTTATTTTGGCGGAATCTTCTTCATCATCCTCCTGACAATCGATAGATACCTG GCTATTGTCCATGCTGTGTTTGCTTTAAAAGCCAGGACGGTCACCTTTGGGGTGGTGACA AGTGTGATCACCTGGTTGGTGGCTGTGTTTGCTTCTGTCCCAGGAATCATCTTTACTAAA TGCCAGAAAGAAGATTCTGTTTATGTCTGTGGCCCTTATTTTCCACGAGGATGGAATAAT TTCCACACAATAATGAGGAACATTTTGGGGCTGGTCCTGCCGCTGCTCATCATGGTCATC TGCTACTCGGGAATCCTGAAAACCCTGCTTCGGTGTCGAAACGAGAAGAAGAGGCATAGG GCAGTGAGAGTCATCTTCACCATCATGATTGTTTACTTTCTCTTCTGGACTCCCTATAAT ATTGTCATTCTCCTGAACACCTTCCAGGAATTCTTCGGCCTGAGTAACTGTGAAAGCACC AGTCAACTGGACCAAGCCACGCAGGTGACAGAGACTCTTGGGATGACTCACTGCTGCATC AATCCCATCATCTATGCCTTCGTTGGGGAGAAGTTCAGAAGCCTTTTTCACATAGCTCTT GGCTGTAGGATTGCCCCACTCCAAAAACCAGTGTGTGGAGGTCCAGGAGTGAGACCAGGA AAGAATGTGAAAGTGACTACACAAGGACTCCTCGATGGTCGTGGAAAAGGAAAGTCAATT GGCAGAGCCCCTGAAGCCAGTCTTCAGGACAAAGAAGGAGCCTAG
- Chromosome Location
- 3
- Locus
- 3p21.31
- External Identifiers
Resource Link UniProtKB ID P41597 UniProtKB Entry Name CCR2_HUMAN GenBank Gene ID U03882 GenAtlas ID CCR2 HGNC ID HGNC:1603 - General References
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