Aldo-keto reductase family 1 member C3
Details
- Name
- Aldo-keto reductase family 1 member C3
- Synonyms
- 1.-.-.-
- 17-beta-HSD 5
- 17-beta-hydroxysteroid dehydrogenase type 5
- 3-alpha-HSD type 2
- 3-alpha-HSD type II, brain
- 3-alpha-hydroxysteroid dehydrogenase type 2
- Chlordecone reductase homolog HAKRb
- DD-3
- DD3
- DDH1
- Dihydrodiol dehydrogenase 3
- Dihydrodiol dehydrogenase type I
- HA1753
- HSD17B5
- Indanol dehydrogenase
- KIAA0119
- PGFS
- Prostaglandin F synthase
- Testosterone 17-beta-dehydrogenase 5
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase
- Gene Name
- AKR1C3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0037052|Aldo-keto reductase family 1 member C3 MDSKHQCVKLNDGHFMPVLGFGTYAPPEVPRSKALEVTKLAIEAGFRHIDSAHLYNNEEQ VGLAIRSKIADGSVKREDIFYTSKLWSTFHRPELVRPALENSLKKAQLDYVDLYLIHSPM SLKPGEELSPTDENGKVIFDIVDLCTTWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKP GLKYKPVCNQVECHPYFNRSKLLDFCKSKDIVLVAYSALGSQRDKRWVDPNSPVLLEDPV LCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTAEDMKAIDGLD RNLHYFNSDSFASHPNYPYSDEY
- Number of residues
- 323
- Molecular Weight
- 36852.89
- Theoretical pI
- 8.06
- GO Classification
- Functions15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity / alditol / aldo-keto reductase (NADP) activity / androsterone dehydrogenase activity / delta4-3-oxosteroid 5beta-reductase activity / dihydrotestosterone 17-beta-dehydrogenase activity / geranylgeranyl reductase activity / indanol dehydrogenase activity / ketoreductase activity / ketosteroid monooxygenase activity / oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor / phenanthrene 9,10-monooxygenase activity / prostaglandin D2 11-ketoreductase activity / prostaglandin-F synthase activity / retinal dehydrogenase activity / retinol dehydrogenase activity / testosterone 17-beta-dehydrogenase (NADP+) activity / testosterone dehydrogenase (NAD+) activity / trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activityProcessesarachidonic acid metabolic process / cellular response to cadmium ion / cellular response to calcium ion / cellular response to corticosteroid stimulus / cellular response to jasmonic acid stimulus / cellular response to prostaglandin D stimulus / cellular response to prostaglandin stimulus / cellular response to reactive oxygen species / cellular response to starvation / cyclooxygenase pathway / daunorubicin metabolic process / doxorubicin metabolic process / farnesol catabolic process / G-protein coupled receptor signaling pathway / keratinocyte differentiation / male gonad development / multicellular organismal macromolecule metabolic process / negative regulation of retinoic acid biosynthetic process / oxidation-reduction process / phototransduction, visible light / positive regulation of cell death / positive regulation of cell proliferation / positive regulation of endothelial cell apoptotic process / positive regulation of protein kinase B signaling / positive regulation of reactive oxygen species metabolic process / progesterone metabolic process / prostaglandin metabolic process / protein import into nucleus, translocation / regulation of retinoic acid receptor signaling pathway / regulation of testosterone biosynthetic process / renal absorption / response to nutrient / retinal metabolic process / retinoid metabolic process / small molecule metabolic process / steroid metabolic process / testosterone biosynthetic processComponentscytoplasm / cytosol / extracellular exosome / intracellular / nucleus
- General Function
- Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
- Specific Function
- Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.
- Pfam Domain Function
- Aldo_ket_red (PF00248)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0018982|Aldo-keto reductase family 1 member C3 (AKR1C3) ATGGATTCAAAACATCAGTGTTTGAAGCTAAATGATGGTCACTTCATGCCTGTCCTGGGA TTTGGCACCTATGCACCTCCAGAGGTTCCGAGAAGTAAAGCTTTGGAGGTCACAAAATTA GCAATAGAAGCTGGGTTCCGCCATATAGATTCTGCTCATTTATACAATAATGAGGAGCAG GTTGGACTGGCCATCCGAAGCAAGATTGCAGATGGCAGTGTGAAGAGAGAAGACATATTC TACACTTCAAAGCTTTGGTCCACTTTTCATCGACCAGAGTTGGTCCGACCAGCCTTGGAA AACTCACTGAAGAAAGCTCAATTGGACTATGTTGACCTCTATCTTATTCATTCTCCAATG TCTCTAAAGCCAGGTGAGGAACTTTCACCAACAGATGAAAATGGAAAAGTAATATTTGAC ATAGTGGATCTCTGTACCACCTGGGAGGCCATGGAGAAGTGTAAGGATGCAGGATTGGCC AAGTCCATTGGGGTGTCAAACTTCAACCGCAGGCAGCTGGAGATGATCCTCAACAAGCCA GGACTCAAGTACAAGCCTGTCTGCAACCAGGTAGAATGTCATCCGTATTTCAACCGGAGT AAATTGCTAGATTTCTGCAAGTCGAAAGATATTGTTCTGGTTGCCTATAGTGCTCTGGGA TCTCAACGAGACAAACGATGGGTGGACCCGAACTCCCCGGTGCTCTTGGAGGACCCAGTC CTTTGTGCCTTGGCAAAAAAGCACAAGCGAACCCCAGCCCTGATTGCCCTGCGCTACCAG CTGCAGCGTGGGGTTGTGGTCCTGGCCAAGAGCTACAATGAGCAGCGCATCAGACAGAAC GTGCAGGTTTTTGAGTTCCAGTTGACTGCAGAGGACATGAAAGCCATAGATGGCCTAGAC AGAAATCTCCACTATTTTAACAGTGATAGTTTTGCTAGCCACCCTAATTATCCATATTCA GATGAATATTAA
- Chromosome Location
- 10
- Locus
- 10p15-p14
- External Identifiers
Resource Link UniProtKB ID P42330 UniProtKB Entry Name AK1C3_HUMAN GenBank Protein ID 4261711 GenBank Gene ID S68288 GenAtlas ID AKR1C3 HGNC ID HGNC:386 - General References
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00157 NADH approved, nutraceutical unknown Details DB01698 Rutin approved, experimental, investigational unknown Details DB02056 Prostaglandin D2 investigational unknown Details DB02266 Flufenamic acid approved unknown Details DB01536 Androstenedione experimental, illicit yes substrateinducer Details DB03461 Nicotinamide adenine dinucleotide phosphate experimental unknown Details DB07700 3-carboxamido-1,3,5(10)-estratrien-17(R)-spiro-2'(5',5'-dimethyl-6'oxo)tetrahydropyran experimental unknown Details DB00997 Doxorubicin approved, investigational no substrate Details DB00328 Indomethacin approved, investigational unknown inhibitor Details DB13751 Glycyrrhizic acid approved, experimental no substrate Details DB01039 Fenofibrate approved unknown substrate Details DB00776 Oxcarbazepine approved unknown substrate Details DB09074 Olaparib approved unknown inhibitor Details DB02901 Stanolone illicit, investigational unknown product of Details DB01561 Androstanedione experimental, illicit unknown substrate Details DB01536 Androstenedione experimental, illicit no substrate Details DB00959 Methylprednisolone approved, vet_approved unknown substrate Details DB06077 Lumateperone approved, investigational no substrate Details