Protein RecA
Details
- Name
- Protein RecA
- Synonyms
- Recombinase A
- Gene Name
- recA
- Organism
- Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)
- Amino acid sequence
>lcl|BSEQ0010877|Protein RecA MSKDATKEISAPTDAKERSKAIETAMSQIEKAFGKGSIMKLGAESKLDVQVVSTGSLSLD LALGVGGIPRGRITEIYGPESGGKTTLALAIVAQAQKAGGTCAFIDAEHALDPVYARALG VNTDELLVSQPDNGEQALEIMELLVRSGAIDVVVVDSVAALTPRAEIEGDMGDSLPGLQA RLMSQALRKLTAILSKTGTAAIFINQVREKIGVMYGNPETTTGGRALKFYASVRLDVRKI GQPTKVGNDAVANTVKIKTVKNKVAAPFKEVELALVYGKGFDQLSDLVGLAADMDIIKKA GSFYSYGDERIGQGKEKTIAYIAERPEMEQEIRDRVMAAIRAGNAGEAPALAPAPAAPEA AEA
- Number of residues
- 363
- Molecular Weight
- 38144.36
- Theoretical pI
- 5.19
- GO Classification
- FunctionsATP binding / damaged DNA binding / DNA-dependent ATPase activity / double-stranded DNA binding / four-way junction DNA binding / recombinase activity / single-stranded DNA bindingProcessesDNA recombinase assembly / double-strand break repair / mitotic recombination / response to ionizing radiation / SOS response / strand invasionComponentscytosol
- General Function
- Single-stranded dna binding
- Specific Function
- Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.
- Pfam Domain Function
- RecA (PF00154)
- Transmembrane Regions
- Not Available
- Cellular Location
- Cytoplasm
- Gene sequence
>lcl|BSEQ0010878|Protein RecA (recA) ATGAGCAAGGACGCCACCAAAGAAATCTCCGCCCCCACCGACGCCAAGGAACGCAGCAAG GCCATCGAAACAGCCATGAGCCAGATCGAAAAGGCCTTCGGCAAGGGCTCGATCATGAAA CTGGGCGCCGAGAGCAAACTCGACGTGCAGGTCGTCAGCACCGGCAGCCTCAGCCTTGAC CTCGCACTGGGCGTGGGCGGCATTCCGCGTGGCCGCATCACCGAGATCTACGGCCCCGAG TCGGGCGGCAAGACCACCCTGGCCCTCGCCATCGTCGCGCAGGCCCAGAAAGCGGGCGGC ACCTGTGCGTTTATCGACGCCGAGCACGCGCTCGACCCGGTGTACGCCCGCGCCCTGGGC GTGAACACCGACGAACTGCTGGTGTCGCAGCCCGACAACGGCGAGCAGGCGCTCGAAATC ATGGAACTGCTGGTGCGTTCGGGCGCGATTGATGTGGTGGTCGTGGACTCGGTGGCTGCT CTGACCCCCCGCGCCGAAATCGAGGGCGACATGGGCGACAGCCTGCCCGGTCTTCAGGCC CGCCTGATGTCGCAGGCGCTGCGCAAGCTGACGGCGATTCTCTCCAAGACCGGCACCGCC GCCATCTTCATCAACCAGGTTCGCGAGAAAATCGGCGTGATGTACGGCAACCCCGAAACC ACCACCGGGGGCCGGGCGCTGAAGTTCTACGCCAGCGTGCGCCTCGACGTGCGTAAGATC GGCCAGCCCACCAAGGTCGGCAACGACGCGGTCGCCAACACCGTCAAGATCAAGACCGTG AAGAACAAGGTCGCCGCCCCCTTCAAGGAAGTCGAACTCGCGCTGGTCTACGGCAAGGGC TTCGACCAGCTCAGCGACCTCGTGGGCCTGGCCGCCGACATGGACATCATCAAGAAGGCC GGCAGCTTCTACTCCTACGGCGACGAGCGCATCGGCCAGGGCAAGGAAAAGACCATCGCC TACATCGCCGAGCGCCCCGAGATGGAGCAGGAAATCCGCGACCGCGTGATGGCCGCCATC CGCGCGGGCAACGCGGGCGAAGCACCGGCCCTGGCCCCCGCGCCTGCCGCGCCCGAAGCC GCCGAAGCGTAA
- Chromosome Location
- Not Available
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P42443 UniProtKB Entry Name RECA_DEIRA GenBank Protein ID 3478632 GenBank Gene ID U01876 - General References
- Gutman PD, Carroll JD, Masters CI, Minton KW: Sequencing, targeted mutagenesis and expression of a recA gene required for the extreme radioresistance of Deinococcus radiodurans. Gene. 1994 Apr 8;141(1):31-7. [Article]
- Narumi I, Satoh K, Kikuchi M, Funayama T, Kitayama S, Yanagisawa T, Watanabe H, Yamamoto K: Molecular analysis of the Deinococcus radiodurans recA locus and identification of a mutation site in a DNA repair-deficient mutant, rec30. Mutat Res. 1999 Dec 7;435(3):233-43. [Article]
- White O, Eisen JA, Heidelberg JF, Hickey EK, Peterson JD, Dodson RJ, Haft DH, Gwinn ML, Nelson WC, Richardson DL, Moffat KS, Qin H, Jiang L, Pamphile W, Crosby M, Shen M, Vamathevan JJ, Lam P, McDonald L, Utterback T, Zalewski C, Makarova KS, Aravind L, Daly MJ, Minton KW, Fleischmann RD, Ketchum KA, Nelson KE, Salzberg S, Smith HO, Venter JC, Fraser CM: Genome sequence of the radioresistant bacterium Deinococcus radiodurans R1. Science. 1999 Nov 19;286(5444):1571-7. [Article]
- Xu G, Lu H, Wang L, Chen H, Xu Z, Hu Y, Tian B, Hua Y: DdrB stimulates single-stranded DNA annealing and facilitates RecA-independent DNA repair in Deinococcus radiodurans. DNA Repair (Amst). 2010 Jul 1;9(7):805-12. doi: 10.1016/j.dnarep.2010.04.006. Epub 2010 May 6. [Article]