Excitatory amino acid transporter 2
Details
- Name
- Excitatory amino acid transporter 2
- Synonyms
- EAAT2
- GLT1
- Glutamate/aspartate transporter II
- Sodium-dependent glutamate/aspartate transporter 2
- Solute carrier family 1 member 2
- Gene Name
- SLC1A2
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0001762|Excitatory amino acid transporter 2 MASTEGANNMPKQVEVRMHDSHLGSEEPKHRHLGLRLCDKLGKNLLLTLTVFGVILGAVC GGLLRLASPIHPDVVMLIAFPGDILMRMLKMLILPLIISSLITGLSGLDAKASGRLGTRA MVYYMSTTIIAAVLGVILVLAIHPGNPKLKKQLGPGKKNDEVSSLDAFLDLIRNLFPENL VQACFQQIQTVTKKVLVAPPPDEEANATSAVVSLLNETVTEVPEETKMVIKKGLEFKDGM NVLGLIGFFIAFGIAMGKMGDQAKLMVDFFNILNEIVMKLVIMIMWYSPLGIACLICGKI IAIKDLEVVARQLGMYMVTVIIGLIIHGGIFLPLIYFVVTRKNPFSFFAGIFQAWITALG TASSAGTLPVTFRCLEENLGIDKRVTRFVLPVGATINMDGTALYEAVAAIFIAQMNGVVL DGGQIVTVSLTATLASVGAASIPSAGLVTMLLILTAVGLPTEDISLLVAVDWLLDRMRTS VNVVGDSFGAGIVYHLSKSELDTIDSQHRVHEDIEMTKTQSIYDDMKNHRESNSNQCVYA AHNSVIVDECKVTLAANGKSADCSVEEEPWKREK
- Number of residues
- 574
- Molecular Weight
- 62103.665
- Theoretical pI
- 6.51
- GO Classification
- Functionsglutamate / L-glutamate transmembrane transporter activity / sodiumProcessesadult behavior / cellular response to extracellular stimulus / D-aspartate import / glutamate secretion / ion transport / L-glutamate import / L-glutamate transmembrane transport / multicellular organism growth / multicellular organismal aging / neurotransmitter secretion / positive regulation of glucose import / response to amino acid / response to drug / response to wounding / synaptic transmission / telencephalon development / transmembrane transport / visual behaviorComponentsaxolemma / cell surface / integral component of membrane / membrane / plasma membrane
- General Function
- Sodium:dicarboxylate symporter activity
- Specific Function
- Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.
- Pfam Domain Function
- SDF (PF00375)
- Transmembrane Regions
- 45-64 88-108 121-142 240-259 280-301 317-339 406-430 437-459
- Cellular Location
- Membrane
- Gene sequence
>lcl|BSEQ0019025|Excitatory amino acid transporter 2 (SLC1A2) ATGCCCAAGCAGGTGGAAGTGCGAATGCACGACAGTCATCTTGGCTCAGAGGAACCCAAG CACCGGCACCTGGGCCTGCGCCTGTGTGACAAGCTGGGGAAGAATCTGCTGCTCACCCTG ACGGTGTTTGGTGTCATCCTGGGAGCAGTGTGTGGAGGGCTTCTTCGCTTGGCATCTCCC ATCCACCCTGATGTGGTTATGTTAATAGCCTTCCCAGGGGATATACTCATGAGGATGCTA AAAATGCTCATTCTCCCTCTAATCATCTCCAGCTTAATCACAGGGTTGTCAGGCCTGGAT GCTAAGGCTAGTGGCCGCTTGGGCACGAGAGCCATGGTGTATTACATGTCCACGACCATC ATTGCTGCAGTACTGGGGGTCATTCTGGTCTTGGCTATCCATCCAGGCAATCCCAAGCTC AAGAAGCAGCTGGGGCCTGGGAAGAAGAATGATGAAGTGTCCAGCCTGGATGCCTTCCTG GACCTTATTCGAAATCTCTTCCCTGAAAACCTTGTCCAAGCCTGCTTTCAACAGATTCAA ACAGTGACGAAGAAAGTCCTGGTTGCACCACCGCCGGACGAGGAGGCCAACGCAACCAGC GCTGTTGTCTCTCTGTTGAACGAGACTGTGACTGAGGTGCCGGAGGAGACTAAGATGGTT ATCAAGAAGGGCCTGGAGTTCAAGGATGGGATGAACGTCTTAGGTCTGATAGGGTTTTTC ATTGCTTTTGGCATCGCTATGGGGAAGATGGGAGATCAGGCCAAGCTGATGGTGGATTTC TTCAACATTTTGAATGAGATTGTAATGAAGTTAGTGATCATGATCATGTGGTACTCTCCC CTGGGTATCGCCTGCCTGATCTGTGGAAAGATCATTGCAATCAAGGACTTAGAAGTGGTT GCTAGGCAACTGGGGATGTACATGGTAACAGTGATCATAGGCCTCATCATCCACGGGGGC ATCTTTCTCCCCTTGATTTACTTTGTAGTGACCAGGAAAAACCCCTTCTCCTTTTTTGCT GGCATTTTCCAAGCTTGGATCACTGCCCTGGGCACCGCTTCCAGTGCTGGAACTTTGCCT GTCACCTTTCGTTGCCTGGAAGAAAATCTGGGGATTGATAAGCGTGTGACTAGATTCGTC CTTCCTGTTGGAGCAACCATTAACATGGATGGTACAGCCCTTTATGAAGCGGTAGCCGCC ATCTTTATAGCCCAAATGAATGGTGTTGTCCTGGATGGAGGACAGATTGTGACTGTAAGC CTCACAGCCACCCTGGCAAGCGTCGGCGCGGCCAGTATCCCCAGTGCCGGGCTGGTCACC ATGCTCCTCATTCTGACAGCCGTGGGCCTGCCAACAGAGGACATCAGCCTGCTGGTGGCT GTGGACTGGCTGCTGGACAGGATGAGAACTTCAGTCAATGTTGTGGGTGACTCTTTTGGG GCTGGGATAGTCTATCACCTCTCCAAGTCTGAGCTGGATACCATTGACTCCCAGCATCGA GTGCATGAAGATATTGAAATGACCAAGACTCAATCCATTTATGATGACATGAAGAACCAC AGGGAAAGCAACTCTAATCAATGTGTCTATGCTGCACACAACTCTGTCATAGTAGATGAA TGCAAGGTAACTCTGGCAGCCAATGGAAAGTCAGCCGACTGCAGTGTTGAGGAAGAACCT TGGAAACGTGAGAAATAA
- Chromosome Location
- 11
- Locus
- 11p13-p12
- External Identifiers
Resource Link UniProtKB ID P43004 UniProtKB Entry Name EAA2_HUMAN GenBank Protein ID 487341 GenBank Gene ID U03505 GenAtlas ID SLC1A2 HGNC ID HGNC:10940 - General References
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