Prostaglandin E2 receptor EP3 subtype
Details
- Name
- Prostaglandin E2 receptor EP3 subtype
- Synonyms
- PGE receptor EP3 subtype
- PGE2-R
- Prostanoid EP3 receptor
- Gene Name
- PTGER3
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0004665|Prostaglandin E2 receptor EP3 subtype MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLL TGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRW EHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLG VWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLL ALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLI MMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQI RYHTNNYASSSTSLPCQCSSTLMWSDHLER
- Number of residues
- 390
- Molecular Weight
- 43309.335
- Theoretical pI
- 10.05
- GO Classification
- Functionsprostaglandin E receptor activity / RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA bindingProcessesadenylate cyclase-modulating G-protein coupled receptor signaling pathway / bicarbonate transport / cell death / fever generation / G-protein coupled receptor signaling pathway / intracellular receptor signaling pathway / phospholipase C-activating G-protein coupled receptor signaling pathway / positive regulation of cytosolic calcium ion concentration / positive regulation of fever generation / positive regulation of urine volume / response to lipopolysaccharide / transcription, DNA-templatedComponentscytosol / integral component of membrane / integral component of plasma membrane / nuclear envelope / plasma membrane
- General Function
- Rna polymerase ii transcription factor activity, ligand-activated sequence-specific dna binding
- Specific Function
- Receptor for prostaglandin E2 (PGE2); the EP3 receptor may be involved in inhibition of gastric acid secretion, modulation of neurotransmitter release in central and peripheral neurons, inhibition of sodium and water reabsorption in kidney tubulus and contraction in uterine smooth muscle. The activity of this receptor can couple to both the inhibition of adenylate cyclase mediated by G-I proteins, and to an elevation of intracellular calcium. The various isoforms have identical ligand binding properties but can interact with different second messenger systems (By similarity).
- Pfam Domain Function
- 7tm_1 (PF00001)
- Transmembrane Regions
- 54-78 92-112 132-153 176-197 228-253 284-307 328-349
- Cellular Location
- Cell membrane
- Gene sequence
>lcl|BSEQ0011703|Prostaglandin E2 receptor EP3 subtype (PTGER3) ATGAAGGAGACCCGGGGCTACGGAGGGGATGCCCCCTTCTGCACCCGCCTCAACCACTCC TACACAGGCATGTGGGCGCCCGAGCGTTCCGCCGAGGCGCGGGGCAACCTCACGCGCCCT CCAGGGTCTGGCGAGGATTGCGGATCGGTGTCCGTGGCCTTCCCGATCACCATGCTGCTC ACTGGTTTCGTGGGCAACGCACTGGCCATGCTGCTCGTGTCGCGCAGCTACCGGCGCCGG GAGAGCAAGCGCAAGAAGTCCTTCCTGCTGTGCATCGGCTGGCTGGCGCTCACCGACCTG GTCGGGCAGCTTCTCACCACCCCGGTCGTCATCGTCGTGTACCTGTCCAAGCAGCGTTGG GAGCACATCGACCCGTCGGGGCGGCTCTGCACCTTTTTCGGGCTGACCATGACTGTTTTC GGGCTCTCCTCGTTGTTCATCGCCAGCGCCATGGCCGTCGAGCGGGCGCTGGCCATCAGG GCGCCGCACTGGTATGCGAGCCACATGAAGACGCGTGCCACCCGCGCTGTGCTGCTCGGC GTGTGGCTGGCCGTGCTCGCCTTCGCCCTGCTGCCGGTGCTGGGCGTGGGCCAGTACACC GTCCAGTGGCCCGGGACGTGGTGCTTCATCAGCACCGGGCGAGGGGGCAACGGGACTAGC TCTTCGCATAACTGGGGCAACCTTTTCTTCGCCTCTGCCTTTGCCTTCCTGGGGCTCTTG GCGCTGACAGTCACCTTTTCCTGCAACCTGGCCACCATTAAGGCCCTGGTGTCCCGCTGC CGGGCCAAGGCCACGGCATCTCAGTCCAGTGCCCAGTGGGGCCGCATCACGACCGAGACG GCCATTCAGCTTATGGGGATCATGTGCGTGCTGTCGGTCTGCTGGTCTCCGCTCCTGATA ATGATGTTGAAAATGATCTTCAATCAGACATCAGTTGAGCACTGCAAGACACACACGGAG AAGCAGAAAGAATGCAACTTCTTCTTAATAGCTGTTCGCCTGGCTTCACTGAACCAGATC TTGGATCCTTGGGTTTACCTGCTGTTAAGAAAGATCCTTCTTCGAAAGTTTTGCCAGATC AGGTACCACACAAACAACTATGCATCCAGCTCCACCTCCTTACCCTGCCAGTGTTCCTCA ACCTTGATGTGGAGCGACCATTTGGAAAGATGA
- Chromosome Location
- 1
- Locus
- 1p31.2
- External Identifiers
Resource Link UniProtKB ID P43115 UniProtKB Entry Name PE2R3_HUMAN GenBank Gene ID S69200 GenAtlas ID PTGER3 HGNC ID HGNC:9595 - General References
- Adam M, Boie Y, Rushmore TH, Muller G, Bastien L, McKee KT, Metters KM, Abramovitz M: Cloning and expression of three isoforms of the human EP3 prostanoid receptor. FEBS Lett. 1994 Jan 31;338(2):170-4. [Article]
- Schmid A, Thierauch KH, Schleuning WD, Dinter H: Splice variants of the human EP3 receptor for prostaglandin E2. Eur J Biochem. 1995 Feb 15;228(1):23-30. [Article]
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Drug Relations
- Drug Relations
DrugBank ID Name Drug group Pharmacological action? Actions Details DB00905 Bimatoprost approved, investigational yes agonist Details DB00917 Dinoprostone approved yes agonist Details DB00929 Misoprostol approved yes agonist Details DB09211 Limaprost investigational unknown agonist Details DB08964 Gemeprost approved, withdrawn yes agonist Details DB11113 Castor oil approved, investigational, nutraceutical, vet_approved yes agonistactivator Details DB00770 Alprostadil approved, investigational yes agonist Details DB16315 Rivenprost investigational yes agonist Details DB04297 Trichostatin A experimental unknown regulator Details