Carbonic anhydrase 7

Details

Name
Carbonic anhydrase 7
Synonyms
  • 4.2.1.1
  • CA-VII
  • Carbonate dehydratase VII
  • Carbonic anhydrase VII
Gene Name
CA7
Organism
Human
Amino acid sequence
>lcl|BSEQ0006977|Carbonic anhydrase 7
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLS
ITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSEL
HLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSC
FNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDER
IHMVNNFRPPQPLKGRVVKASFRA
Number of residues
264
Molecular Weight
29658.235
Theoretical pI
7.45
GO Classification
Functions
zinc ion binding / carbonate dehydratase activity
Processes
regulation of chloride transport / small molecule metabolic process / positive regulation of cellular pH reduction / bicarbonate transport / one-carbon metabolic process / positive regulation of defense response to virus by host / xenophagy / mitophagy in response to mitochondrial depolarization / positive regulation of synaptic transmission, GABAergic
Components
cytosol
General Function
Zinc ion binding
Specific Function
Reversible hydration of carbon dioxide.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasm
Gene sequence
>lcl|BSEQ0012523|Carbonic anhydrase 7 (CA7)
ATGTCCCTCAGCATCACCAACAATGGCCACTCTGTCCAGGTAGACTTCAATGACAGCGAT
GACCGAACCGTGGTGACTGGGGGCCCCCTGGAAGGGCCCTACCGCCTCAAGCAGTTTCAC
TTCCACTGGGGCAAGAAGCACGATGTGGGTTCTGAGCACACGGTGGACGGCAAGTCCTTC
CCCAGCGAGCTGCATCTGGTTCACTGGAATGCCAAGAAGTACAGCACTTTTGGGGAGGCG
GCCTCAGCACCTGATGGCCTGGCTGTGGTTGGTGTTTTTTTGGAGACAGGAGACGAGCAC
CCCAGCATGAATCGTCTGACAGATGCGCTCTACATGGTCCGGTTCAAGGGCACCAAAGCC
CAGTTCAGCTGCTTCAACCCCAAGTGCCTCCTGCCTGCCAGCCGGCACTACTGGACCTAC
CCGGGCTCTCTGACGACTCCCCCACTCAGTGAGAGTGTCACCTGGATTGTGCTCCGGGAG
CCCATCTGCATCTCTGAAAGGCAGATGGGGAAGTTCCGGAGCCTGCTTTTTACCTCGGAG
GACGATGAGAGGATCCACATGGTGAACAACTTCCGGCCACCACAGCCACTGAAGGGCCGC
GTGGTAAAGGCCTCCTTCCGGGCCTGA
Chromosome Location
16
Locus
16q22.1
External Identifiers
ResourceLink
UniProtKB IDP43166
UniProtKB Entry NameCAH7_HUMAN
GenBank Protein ID28192445
GenBank Gene IDAY075019
HGNC IDHGNC:1381
General References
Not Available

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB00909Zonisamideapproved, investigationalunknowninhibitorDetails
DB00311EthoxzolamidewithdrawnyesinhibitorDetails
DB00819Acetazolamideapproved, vet_approvedyesinhibitorDetails
DB00703MethazolamideapprovedyesinhibitorDetails
DB01144Diclofenamideapproved, investigationalyesinhibitorDetails
DB08846Ellagic AcidinvestigationalunknowninhibitorDetails