tRNA (guanine-N(1)-)-methyltransferase

Details

Name

tRNA (guanine-N(1)-)-methyltransferase

Synonyms

• 2.1.1.228
• M1G-methyltransferase
• tRNA [GM37] methyltransferase

Gene Name

trmD

Organism

Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)

Amino acid sequence

>lcl|BSEQ0011801|tRNA (guanine-N(1)-)-methyltransferase
MWIGVISLFPEMFKAITEFGVTGRAVKHNLLKVECWNPRDFTFDKHKTVDDRPYGGGPGM
LMMVQPLRDAIHTAKAAAGEGAKVIYLSPQGRKLDQGGVTELAQNQKLILVCGRYEGIDE
RLIQTEIDEEWSIGDYVLTGGELPAMTLIDAVARFIPGVLGKQASAEEDSFADGLLDCPH
YTRPEVLEGLTVPPVLMSGHHEEIRKWRLKQSLQRTWLRRPELLEGLALTDEQRKLLKEA
QAEHNS

Number of residues

246

Molecular Weight

27542.435

Theoretical pI

5.65

GO Classification

Functions

tRNA (guanine(37)-N(1))-methyltransferase activity

Components

cytoplasm

General Function

Trna (guanine(37)-n(1))-methyltransferase activity

Specific Function

Specifically methylates guanosine-37 in various tRNAs.

Pfam Domain Function

• tRNA_m1G_MT (PF01746)

Transmembrane Regions

Not Available

Cellular Location

Cytoplasm

Gene sequence

>lcl|BSEQ0011802|tRNA (guanine-N(1)-)-methyltransferase (trmD)
ATGTGGATAGGGGTAATTTCATTATTCCCCGAAATGTTTAAAGCAATTACGGAATTTGGG
GTTACAGGTAGAGCCGTAAAACATAATCTTCTGAAAGTTGAATGTTGGAATCCAAGAGAT
TTTACATTCGACAAGCATAAAACCGTGGACGATCGCCCTTATGGTGGTGGCCCAGGAATG
CTAATGATGGTGCAACCTTTACGGGATGCGATTCATACTGCAAAAGCTGCGGCAGGAGAA
GGCGCAAAGGTGATTTACCTTTCGCCACAAGGACGTAAACTCGATCAAGGCGGCGTAACC
GAGCTTGCTCAAAATCAGAAATTGATTTTAGTATGTGGACGTTACGAAGGGATTGATGAA
CGGTTGATTCAAACTGAAATTGATGAAGAATGGTCAATCGGCGATTACGTTCTGACCGGT
GGGGAATTGCCGGCAATGACATTAATTGATGCTGTTGCACGTTTTATTCCCGGTGTATTA
GGCAAACAAGCCTCGGCAGAAGAAGATTCTTTTGCAGATGGTTTATTAGATTGCCCGCAT
TACACTAGACCAGAAGTGTTAGAAGGATTAACTGTACCACCCGTGCTGATGTCGGGACAT
CACGAAGAAATTCGGAAATGGCGATTAAAACAATCGCTACAGAGAACGTGGCTCCGACGC
CCTGAGCTCTTAGAAGGCCTAGCTCTGACTGACGAACAACGTAAGCTGTTAAAAGAGGCG
CAAGCCGAGCATAACAGTTAG

Chromosome Location

Not Available

Locus

Not Available

External Identifiers

Resource	Link
UniProtKB ID	P43912
UniProtKB Entry Name	TRMD_HAEIN
GenBank Gene ID	L42023

General References

1. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, Bult CJ, Tomb JF, Dougherty BA, Merrick JM, et al.: Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995 Jul 28;269(5223):496-512. [Article]
2. Ahn HJ, Kim HW, Yoon HJ, Lee BI, Suh SW, Yang JK: Crystal structure of tRNA(m1G37)methyltransferase: insights into tRNA recognition. EMBO J. 2003 Jun 2;22(11):2593-603. [Article]

Drug Relations

Drug Relations

DrugBank ID	Name	Drug group	Pharmacological action?	Actions	Details
DB01752	S-adenosyl-L-homocysteine	experimental	unknown		Details