ATP-binding cassette sub-family G member 1
Details
- Name
- ATP-binding cassette sub-family G member 1
- Synonyms
- ABC8
- ATP-binding cassette transporter 8
- White protein homolog
- WHT1
- Gene Name
- ABCG1
- Organism
- Humans
- Amino acid sequence
>lcl|BSEQ0002323|ATP-binding cassette sub-family G member 1 MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNL TEAQRFSSLPRRAAVNIEFRDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPS GAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFF DEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGK VCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDS VLTHLRITSHIGIGLLIGLLYLGIGNEAKKVLSNSGFLFFSMLFLMFAALMPTVLTFPLE MGVFLREHLNYWYSLKAYYLAKTMADVPFQIMFPVAYCSIVYWMTSQPSDAVRFVLFAAL GTMTSLVAQSLGLLIGAASTSLQVATFVGPVTAIPVLLFSGFFVSFDTIPTYLQWMSYIS YVRYGFEGVILSIYGLDREDLHCDIDETCHFQKSEAILRELDVENAKLYLDFIVLGIFFI SLRLIAYFVLRYKIRAER
- Number of residues
- 678
- Molecular Weight
- 75591.275
- Theoretical pI
- 7.87
- GO Classification
- FunctionsADP binding / ATP binding / cholesterol binding / cholesterol transporter activity / glycoprotein transporter activity / phospholipid binding / phospholipid transporter activity / protein dimerization activity / protein heterodimerization activity / protein homodimerization activity / sterol-transporting ATPase activity / toxin transporter activityProcessesamyloid precursor protein catabolic process / cholesterol efflux / cholesterol homeostasis / cholesterol metabolic process / detection of hormone stimulus / glycoprotein transport / high-density lipoprotein particle remodeling / intracellular cholesterol transport / lipoprotein metabolic process / low-density lipoprotein particle remodeling / negative regulation of cholesterol storage / negative regulation of macrophage derived foam cell differentiation / phospholipid efflux / phospholipid homeostasis / positive regulation of cholesterol biosynthetic process / positive regulation of cholesterol efflux / regulation of cholesterol esterification / regulation of transcription, DNA-templated / response to high density lipoprotein particle / response to lipid / response to organic substance / reverse cholesterol transport / small molecule metabolic process / toxin transport / transmembrane transportComponentsendoplasmic reticulum membrane / endosome / external side of plasma membrane / Golgi apparatus / Golgi membrane / integral component of membrane / integral component of plasma membrane / intracellular membrane-bounded organelle / mitochondrion / nucleoplasm / plasma membrane / recycling endosome
- General Function
- Toxin transporter activity
- Specific Function
- Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages.
- Pfam Domain Function
- Transmembrane Regions
- 427-445 457-477 507-525 534-555 568-586 650-669
- Cellular Location
- Endoplasmic reticulum membrane
- Gene sequence
>lcl|BSEQ0010816|ATP-binding cassette sub-family G member 1 (ABCG1) ATGGCCTGTCTGATGGCCGCTTTCTCGGTCGGCACCGCCATGAATGCCAGCAGTTACTCT GCAGAGATGACGGAGCCCAAGTCGGTGTGTGTCTCGGTGGATGAGGTGGTGTCCAGCAAC ATGGAGGCCACTGAGACGGACCTGCTGAATGGACATCTGAAAAAAGTAGATAATAACCTC ACGGAAGCCCAGCGCTTCTCCTCCTTGCCTCGGAGGGCAGCTGTGAACATTGAATTCAGG GACCTTTCCTATTCGGTTCCTGAAGGACCCTGGTGGAGGAAGAAAGGATACAAGACCCTC CTGAAAGGAATTTCCGGGAAGTTCAATAGTGGTGAGTTGGTGGCCATTATGGGTCCTTCC GGGGCCGGGAAGTCCACGCTGATGAACATCCTGGCTGGATACAGGGAGACGGGCATGAAG GGGGCCGTCCTCATCAACGGCCTGCCCCGGGACCTGCGCTGCTTCCGGAAGGTGTCCTGC TACATCATGCAGGATGACATGCTGCTGCCGCATCTCACTGTGCAGGAGGCCATGATGGTG TCGGCACATCTGAAGCTTCAGGAGAAGGATGAAGGCAGAAGGGAAATGGTCAAGGAGATA CTGACAGCGCTGGGCTTGCTGTCTTGCGCCAACACGCGGACCGGGAGCCTGTCAGGTGGT CAGCGCAAGCGCCTGGCCATCGCGCTGGAGCTGGTGAACAACCCTCCAGTCATGTTCTTC GATGAGCCCACCAGCGGCCTGGACAGCGCCTCCTGCTTCCAGGTGGTCTCGCTGATGAAA GGGCTCGCTCAAGGGGGTCGCTCCATCATTTGCACCATCCACCAGCCCAGCGCCAAACTC TTCGAGCTGTTCGACCAGCTTTACGTCCTGAGTCAAGGACAATGTGTGTACCGGGGAAAA GTCTGCAATCTTGTGCCATATTTGAGGGATTTGGGTCTGAACTGCCCAACCTACCACAAC CCAGCAGATTTTGTCATGGAGGTTGCATCCGGCGAGTACGGTGATCAGAACAGTCGGCTG GTGAGAGCGGTTCGGGAGGGCATGTGTGACTCAGACCACAAGAGAGACCTCGGGGGTGAT GCCGAGGTGAACCCTTTTCTTTGGCACCGGCCCTCTGAAGAGGTAAAGCAGACAAAACGA TTAAAGGGGTTGAGAAAGGACTCCTCGTCCATGGAAGGCTGCCACAGCTTCTCTGCCAGC TGCCTCACGCAGTTCTGCATCCTCTTCAAGAGGACCTTCCTCAGCATCATGAGGGACTCG GTCCTGACACACCTGCGCATCACCTCGCACATTGGGATCGGCCTCCTCATTGGCCTGCTG TACTTGGGGATCGGGAACGAAGCCAAGAAGGTCTTGAGCAACTCCGGCTTCCTCTTCTTC TCCATGCTGTTCCTCATGTTCGCGGCCCTCATGCCTACTGTTCTGACATTTCCCCTGGAG ATGGGAGTCTTTCTTCGGGAACACCTGAACTACTGGTACAGCCTGAAGGCCTACTACCTG GCCAAGACCATGGCAGACGTGCCCTTTCAGATCATGTTCCCAGTGGCCTACTGCAGCATC GTGTACTGGATGACGTCGCAGCCGTCCGACGCCGTGCGCTTTGTGCTGTTTGCCGCGCTG GGCACCATGACCTCCCTGGTGGCACAGTCCCTGGGCCTGCTGATCGGAGCCGCCTCCACG TCCCTGCAGGTGGCCACTTTCGTGGGCCCAGTGACAGCCATCCCGGTGCTCCTGTTCTCG GGGTTCTTCGTCAGCTTCGACACCATCCCCACGTACCTACAGTGGATGTCCTACATCTCC TATGTCAGGTATGGGTTCGAAGGGGTCATCCTCTCCATCTATGGCTTAGACCGGGAAGAT CTGCACTGTGACATCGACGAGACGTGCCACTTCCAGAAGTCGGAGGCCATCCTGCGGGAG CTGGACGTGGAAAATGCCAAGCTGTACCTGGACTTCATCGTACTCGGGATTTTCTTCATC TCCCTCCGCCTCATTGCCTATTTTGTCCTCAGGTACAAAATCCGGGCAGAGAGGTAA
- Chromosome Location
- 21
- Locus
- Not Available
- External Identifiers
Resource Link UniProtKB ID P45844 UniProtKB Entry Name ABCG1_HUMAN GenBank Protein ID 1160186 GenBank Gene ID X91249 GenAtlas ID ABCG1 HGNC ID HGNC:73 - General References
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