Voltage-dependent anion-selective channel protein 2

Details

Name
Voltage-dependent anion-selective channel protein 2
Synonyms
  • Outer mitochondrial membrane protein porin 2
  • VDAC-2
Gene Name
VDAC2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0037860|Voltage-dependent anion-selective channel protein 2
MATHGQTCARPMCIPPSYADLGKAARDIFNKGFGFGLVKLDVKTKSCSGVEFSTSGSSNT
DTGKVTGTLETKYKWCEYGLTFTEKWNTDNTLGTEIAIEDQICQGLKLTFDTTFSPNTGK
KSGKIKSSYKRECINLGCDVDFDFAGPAIHGSAVFGYEGWLAGYQMTFDSAKSKLTRNNF
AVGYRTGDFQLHTNVNDGTEFGGSIYQKVCEDLDTSVNLAWTSGTNCTRFGIAAKYQLDP
TASISAKVNNSSLIGVGYTQTLRPGVKLTLSALVDGKSINAGGHKVGLALELEA
Number of residues
294
Molecular Weight
31566.265
Theoretical pI
6.76
GO Classification
Functions
nucleotide binding / porin activity / voltage-gated anion channel activity
Processes
anion transport / negative regulation of intrinsic apoptotic signaling pathway / negative regulation of protein polymerization / regulation of anion transmembrane transport
Components
extracellular exosome / membrane raft / mitochondrial inner membrane / mitochondrial nucleoid / mitochondrial outer membrane / mitochondrion / myelin sheath / nucleus / pore complex
General Function
Voltage-gated anion channel activity
Specific Function
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective.
Pfam Domain Function
Transmembrane Regions
37-46 50-58 65-75 80-87 91-100 106-115 122-131 134-141 148-156 161-169 174-186 189-196 200-209 213-222 229-238 242-249 253-262 265-274 284-293
Cellular Location
Mitochondrion outer membrane
Gene sequence
>lcl|BSEQ0019297|Voltage-dependent anion-selective channel protein 2 (VDAC2)
ATGAGCTGGTGTAATGAGCTCAGATTGCCTGCCCTTAAGCAGCACAGCATTGGCCGAGGA
CTTGAGAGTCACATTACAATGTGTATTCCTCCATCATATGCTGACCTTGGCAAAGCTGCC
AGAGATATTTTCAACAAAGGATTTGGTTTTGGGTTGGTGAAACTGGATGTGAAAACAAAG
TCTTGCAGTGGCGTGGAATTTTCAACGTCCGGTTCATCTAATACAGACACTGGTAAAGTT
ACTGGGACCTTGGAGACCAAATACAAGTGGTGTGAGTATGGTCTGACTTTCACAGAAAAG
TGGAACACTGATAACACTCTGGGAACAGAAATCGCAATTGAAGACCAGATTTGTCAAGGT
TTGAAACTGACATTTGATACTACCTTCTCACCAAACACAGGAAAGAAAAGTGGTAAAATC
AAGTCTTCTTACAAGAGGGAGTGTATAAACCTTGGTTGTGATGTTGACTTTGATTTTGCT
GGACCTGCAATCCATGGTTCAGCTGTCTTTGGTTATGAGGGCTGGCTTGCTGGCTACCAG
ATGACCTTTGACAGTGCCAAATCAAAGCTGACAAGGAATAACTTTGCAGTGGGCTACAGG
ACTGGGGACTTCCAGCTACACACTAATGTCAATGATGGGACAGAATTTGGAGGATCAATT
TATCAGAAAGTTTGTGAAGATCTTGACACTTCAGTAAACCTTGCTTGGACATCAGGTACC
AACTGCACTCGTTTTGGCATTGCAGCTAAATATCAGTTGGATCCCACTGCTTCCATTTCT
GCAAAAGTCAACAACTCTAGCTTAATTGGAGTAGGCTATACTCAGACTCTGAGGCCTGGT
GTGAAGCTTACACTCTCTGCTCTGGTAGATGGGAAGAGCATTAATGCTGGAGGCCACAAG
GTTGGGCTCGCCCTGGAGTTGGAGGCTTAA
Chromosome Location
10
Locus
10q22
External Identifiers
ResourceLink
UniProtKB IDP45880
UniProtKB Entry NameVDAC2_HUMAN
GenBank Gene IDL08666
GenAtlas IDVDAC2
HGNC IDHGNC:12672
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB01375Aluminium monostearateexperimentalunknowninhibitorDetails
DB06098PRLX 93936investigationalunknownDetails