Chromobox protein homolog 5

Details

Name
Chromobox protein homolog 5
Synonyms
  • Antigen p25
  • Heterochromatin protein 1 homolog alpha
  • HP1 alpha
  • HP1A
Gene Name
CBX5
Organism
Humans
Amino acid sequence
>lcl|BSEQ0049824|Chromobox protein homolog 5
MGKKTKRTADSSSSEDEEEYVVEKVLDRRVVKGQVEYLLKWKGFSEEHNTWEPEKNLDCP
ELISEFMKKYKKMKEGENNKPREKSESNKRKSNFSNSADDIKSKKKREQSNDIARGFERG
LEPEKIIGATDSCGDLMFLMKWKDTDEADLVLAKEANVKCPQIVIAFYEERLTWHAYPED
AENKEKETAKS
Number of residues
191
Molecular Weight
22224.81
Theoretical pI
Not Available
GO Classification
Functions
chromatin binding / histone deacetylase binding / methylated histone binding / protein binding, bridging / protein homodimerization activity / repressing transcription factor binding
Processes
blood coagulation / negative regulation of transcription, DNA-templated / viral process
Components
chromocenter / histone deacetylase complex / histone methyltransferase complex / kinetochore / nuclear chromosome, telomeric region / nuclear envelope / nuclear heterochromatin / nuclear pericentric heterochromatin / nucleolus / nucleoplasm / nucleus / pericentric heterochromatin / transcriptional repressor complex
General Function
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.
Specific Function
Chromatin binding
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Nucleus
Gene sequence
>lcl|BSEQ0049825|Chromobox protein homolog 5 (CBX5)
ATGGGAAAGAAAACCAAGCGGACAGCTGACAGTTCTTCTTCAGAGGATGAGGAGGAGTAT
GTTGTGGAGAAGGTGCTAGACAGGCGCGTGGTTAAGGGACAAGTGGAATATCTACTGAAG
TGGAAAGGCTTTTCTGAGGAGCACAATACTTGGGAACCTGAGAAAAACTTGGATTGCCCT
GAGCTAATTTCTGAATTTATGAAAAAGTATAAGAAGATGAAGGAGGGTGAAAATAATAAA
CCCAGGGAGAAGTCAGAAAGTAACAAGAGGAAATCCAATTTCTCAAACAGTGCCGATGAC
ATCAAATCTAAAAAAAAGAGAGAGCAGAGCAATGATATCGCTCGGGGCTTTGAGAGAGGA
CTGGAACCAGAAAAGATCATTGGGGCAACAGATTCCTGTGGTGATTTAATGTTCCTAATG
AAATGGAAAGACACAGATGAAGCTGACCTGGTTCTTGCAAAAGAAGCTAATGTGAAATGT
CCACAAATTGTGATAGCATTTTATGAAGAGAGACTGACATGGCATGCATATCCTGAGGAT
GCGGAAAACAAAGAGAAAGAAACAGCAAAGAGCTAA
Chromosome Location
12
Locus
12q13.13
External Identifiers
ResourceLink
UniProtKB IDP45973
UniProtKB Entry NameCBX5_HUMAN
HGNC IDHGNC:1555
General References
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB09130Copperapproved, investigationalunknownDetails