Stromal cell-derived factor 1

Details

Name
Stromal cell-derived factor 1
Synonyms
  • C-X-C motif chemokine 12
  • hIRH
  • Intercrine reduced in hepatomas
  • IRH
  • PBSF
  • Pre-B cell growth-stimulating factor
  • SDF-1
  • SDF1
  • SDF1A
  • SDF1B
Gene Name
CXCL12
Organism
Humans
Amino acid sequence
>lcl|BSEQ0002287|Stromal cell-derived factor 1
MNAKVVVVLVLVLTALCLSDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIV
ARLKNNNRQVCIDPKLKWIQEYLEKALNKRFKM
Number of residues
93
Molecular Weight
10665.75
Theoretical pI
10.54
GO Classification
Functions
chemoattractant activity / chemokine activity / chemokine receptor binding / CXCR chemokine receptor binding / receptor binding
Processes
adult locomotory behavior / ameboidal-type cell migration / axon guidance / blood circulation / cell adhesion / cell chemotaxis / cellular calcium ion homeostasis / chemokine-mediated signaling pathway / chemotaxis / G-protein coupled receptor signaling pathway / germ cell development / germ cell migration / immune response / induction of positive chemotaxis / motor neuron axon guidance / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of leukocyte apoptotic process / negative regulation of leukocyte tethering or rolling / neuron migration / organ regeneration / patterning of blood vessels / positive chemotaxis / positive regulation of axon extension involved in axon guidance / positive regulation of calcium ion import / positive regulation of cell adhesion / positive regulation of dopamine secretion / positive regulation of endothelial cell proliferation / positive regulation of monocyte chemotaxis / positive regulation of myoblast fusion / positive regulation of T cell migration / regulation of actin polymerization or depolymerization / response to heat / response to hypoxia / response to mechanical stimulus / response to peptide hormone / response to radiation / response to virus / signal transduction / T cell proliferation / telencephalon cell migration
Components
external side of plasma membrane / extracellular exosome / extracellular region / extracellular space
General Function
Not Available
Specific Function
Not Available
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Secreted
Gene sequence
>lcl|BSEQ0020510|Stromal cell-derived factor 1 (CXCL12)
ATGAACGCCAAGGTCGTGGTCGTGCTGGTCCTCGTGCTGACCGCGCTCTGCCTCAGCGAC
GGGAAGCCCGTCAGCCTGAGCTACAGATGCCCATGCCGATTCTTCGAAAGCCATGTTGCC
AGAGCCAACGTCAAGCATCTCAAAATTCTCAACACTCCAAACTGTGCCCTTCAGATTGTA
GCCCGGCTGAAGAACAACAACAGACAAGTGTGCATTGACCCGAAGCTAAAGTGGATTCAG
GAGTACCTGGAGAAAGCTTTAAACAAGAGGTTCAAGATGTGA
Chromosome Location
Not Available
Locus
10q11.1
External Identifiers
ResourceLink
UniProtKB IDP48061
UniProtKB Entry NameSDF1_HUMAN
GenBank Protein ID571508
GenBank Gene IDU16752
GenAtlas IDCXCL12
HGNC IDHGNC:10672
General References
  1. Shirozu M, Nakano T, Inazawa J, Tashiro K, Tada H, Shinohara T, Honjo T: Structure and chromosomal localization of the human stromal cell-derived factor 1 (SDF1) gene. Genomics. 1995 Aug 10;28(3):495-500. [Article]
  2. Yu L, Cecil J, Peng SB, Schrementi J, Kovacevic S, Paul D, Su EW, Wang J: Identification and expression of novel isoforms of human stromal cell-derived factor 1. Gene. 2006 Jun 7;374:174-9. Epub 2006 Apr 19. [Article]
  3. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [Article]
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  7. Oberlin E, Amara A, Bachelerie F, Bessia C, Virelizier JL, Arenzana-Seisdedos F, Schwartz O, Heard JM, Clark-Lewis I, Legler DF, Loetscher M, Baggiolini M, Moser B: The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature. 1996 Aug 29;382(6594):833-5. [Article]
  8. Donzella GA, Schols D, Lin SW, Este JA, Nagashima KA, Maddon PJ, Allaway GP, Sakmar TP, Henson G, De Clercq E, Moore JP: AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor. Nat Med. 1998 Jan;4(1):72-7. [Article]
  9. Amara A, Lorthioir O, Valenzuela A, Magerus A, Thelen M, Montes M, Virelizier JL, Delepierre M, Baleux F, Lortat-Jacob H, Arenzana-Seisdedos F: Stromal cell-derived factor-1alpha associates with heparan sulfates through the first beta-strand of the chemokine. J Biol Chem. 1999 Aug 20;274(34):23916-25. [Article]
  10. Moepps B, Braun M, Knopfle K, Dillinger K, Knochel W, Gierschik P: Characterization of a Xenopus laevis CXC chemokine receptor 4: implications for hematopoietic cell development in the vertebrate embryo. Eur J Immunol. 2000 Oct;30(10):2924-34. [Article]
  11. Braun M, Wunderlin M, Spieth K, Knochel W, Gierschik P, Moepps B: Xenopus laevis Stromal cell-derived factor 1: conservation of structure and function during vertebrate development. J Immunol. 2002 Mar 1;168(5):2340-7. [Article]
  12. De La Luz Sierra M, Yang F, Narazaki M, Salvucci O, Davis D, Yarchoan R, Zhang HH, Fales H, Tosato G: Differential processing of stromal-derived factor-1alpha and stromal-derived factor-1beta explains functional diversity. Blood. 2004 Apr 1;103(7):2452-9. Epub 2003 Oct 2. [Article]
  13. Balabanian K, Lagane B, Infantino S, Chow KY, Harriague J, Moepps B, Arenzana-Seisdedos F, Thelen M, Bachelerie F: The chemokine SDF-1/CXCL12 binds to and signals through the orphan receptor RDC1 in T lymphocytes. J Biol Chem. 2005 Oct 21;280(42):35760-6. Epub 2005 Aug 17. [Article]
  14. Veldkamp CT, Peterson FC, Pelzek AJ, Volkman BF: The monomer-dimer equilibrium of stromal cell-derived factor-1 (CXCL 12) is altered by pH, phosphate, sulfate, and heparin. Protein Sci. 2005 Apr;14(4):1071-81. Epub 2005 Mar 1. [Article]
  15. Veldkamp CT, Seibert C, Peterson FC, Sakmar TP, Volkman BF: Recognition of a CXCR4 sulfotyrosine by the chemokine stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12). J Mol Biol. 2006 Jun 23;359(5):1400-9. Epub 2006 May 11. [Article]
  16. Malik M, Chen YY, Kienzle MF, Tomkowicz BE, Collman RG, Ptasznik A: Monocyte migration and LFA-1-mediated attachment to brain microvascular endothelia is regulated by SDF-1 alpha through Lyn kinase. J Immunol. 2008 Oct 1;181(7):4632-7. [Article]
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  20. Dealwis C, Fernandez EJ, Thompson DA, Simon RJ, Siani MA, Lolis E: Crystal structure of chemically synthesized [N33A] stromal cell-derived factor 1alpha, a potent ligand for the HIV-1 "fusin" coreceptor. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6941-6. [Article]
  21. Ohnishi Y, Senda T, Nandhagopal N, Sugimoto K, Shioda T, Nagal Y, Mitsui Y: Crystal structure of recombinant native SDF-1alpha with additional mutagenesis studies: an attempt at a more comprehensive interpretation of accumulated structure-activity relationship data. J Interferon Cytokine Res. 2000 Aug;20(8):691-700. [Article]
  22. Gozansky EK, Louis JM, Caffrey M, Clore GM: Mapping the binding of the N-terminal extracellular tail of the CXCR4 receptor to stromal cell-derived factor-1alpha. J Mol Biol. 2005 Jan 28;345(4):651-8. [Article]
  23. Murphy JW, Cho Y, Sachpatzidis A, Fan C, Hodsdon ME, Lolis E: Structural and functional basis of CXCL12 (stromal cell-derived factor-1 alpha) binding to heparin. J Biol Chem. 2007 Mar 30;282(13):10018-27. Epub 2007 Jan 29. [Article]
  24. Ryu EK, Kim TG, Kwon TH, Jung ID, Ryu D, Park YM, Kim J, Ahn KH, Ban C: Crystal structure of recombinant human stromal cell-derived factor-1alpha. Proteins. 2007 Jun 1;67(4):1193-7. [Article]
  25. Veldkamp CT, Seibert C, Peterson FC, De la Cruz NB, Haugner JC 3rd, Basnet H, Sakmar TP, Volkman BF: Structural basis of CXCR4 sulfotyrosine recognition by the chemokine SDF-1/CXCL12. Sci Signal. 2008 Sep 16;1(37):ra4. doi: 10.1126/scisignal.1160755. [Article]
  26. Veldkamp CT, Ziarek JJ, Su J, Basnet H, Lennertz R, Weiner JJ, Peterson FC, Baker JE, Volkman BF: Monomeric structure of the cardioprotective chemokine SDF-1/CXCL12. Protein Sci. 2009 Jul;18(7):1359-69. doi: 10.1002/pro.167. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05934CTCE-0214investigationalunknownDetails
DB06822TinzaparinapprovedunknownbinderDetails