Type-2 angiotensin II receptor

Details

Name
Type-2 angiotensin II receptor
Synonyms
  • Angiotensin II type-2 receptor
  • AT2
Gene Name
AGTR2
Organism
Humans
Amino acid sequence
>lcl|BSEQ0012398|Type-2 angiotensin II receptor
MKGNSTLATTSKNITSGLHFGLVNISGNNESTLNCSQKPSDKHLDAIPILYYIIFVIGFL
VNIVVVTLFCCQKGPKKVSSIYIFNLAVADLLLLATLPLWATYYSYRYDWLFGPVMCKVF
GSFLTLNMFASIFFITCMSVDRYQSVIYPFLSQRRNPWQASYIVPLVWCMACLSSLPTFY
FRDVRTIEYLGVNACIMAFPPEKYAQWSAGIALMKNILGFIIPLIFIATCYFGIRKHLLK
TNSYGKNRITRDQVLKMAAAVVLAFIICWLPFHVLTFLDALAWMGVINSCEVIAVIDLAL
PFAILLGFTNSCVNPFLYCFVGNRFQQKLRSVFRVPITWLQGKRESMSCRKSSSLREMET
FVS
Number of residues
363
Molecular Weight
41183.45
Theoretical pI
9.34
GO Classification
Functions
angiotensin type II receptor activity / peptide hormone binding / receptor antagonist activity
Processes
aldosterone secretion / angiotensin-activated signaling pathway / blood vessel remodeling / brain development / brain renin-angiotensin system / cell growth involved in cardiac muscle cell development / cell surface receptor signaling pathway / cellular response to dexamethasone stimulus / cellular sodium ion homeostasis / cerebellar cortex development / dopamine biosynthetic process / exploration behavior / extracellular negative regulation of signal transduction / G-protein coupled receptor signaling pathway / G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger / inflammatory response / intracellular signal transduction / negative regulation of blood vessel endothelial cell migration / negative regulation of cell growth / negative regulation of fibroblast proliferation / negative regulation of heart rate / negative regulation of icosanoid secretion / negative regulation of neurotrophin TRK receptor signaling pathway / negative regulation of norepinephrine secretion / nitric oxide mediated signal transduction / positive regulation of branching involved in ureteric bud morphogenesis / positive regulation of cell proliferation / positive regulation of cytokine secretion / positive regulation of extrinsic apoptotic signaling pathway / positive regulation of metanephric glomerulus development / positive regulation of nitric oxide biosynthetic process / positive regulation of nitric-oxide synthase activity / positive regulation of phosphoprotein phosphatase activity / positive regulation of renal sodium excretion / positive regulation of transcription, DNA-templated / positive regulation of vasodilation / regulation of blood pressure / regulation of metanephros size / regulation of systemic arterial blood pressure by circulatory renin-angiotensin / regulation of transcription factor import into nucleus / renin-angiotensin regulation of aldosterone production / response to organonitrogen compound / vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
Components
extracellular region / integral component of plasma membrane / perinuclear region of cytoplasm / plasma membrane
General Function
Receptor antagonist activity
Specific Function
Receptor for angiotensin II. Cooperates with MTUS1 to inhibit ERK2 activation and cell proliferation.
Pfam Domain Function
Transmembrane Regions
46-71 81-102 120-140 161-179 209-234 257-278 298-318
Cellular Location
Cell membrane
Gene sequence
>lcl|BSEQ0012399|Type-2 angiotensin II receptor (AGTR2)
ATGAAGGGCAACTCCACCCTTGCCACTACTAGCAAAAACATTACCAGCGGTCTTCACTTC
GGGCTTGTGAACATCTCTGGCAACAATGAGTCTACCTTGAACTGTTCACAGAAACCATCA
GATAAGCATTTAGATGCAATTCCTATTCTTTACTACATTATATTTGTAATTGGATTTCTG
GTCAATATTGTCGTGGTTACACTGTTTTGTTGTCAAAAGGGTCCTAAAAAGGTTTCTAGC
ATATACATCTTCAACCTCGCTGTGGCTGATTTACTCCTTTTGGCTACTCTTCCTCTATGG
GCAACCTATTATTCTTATAGATATGACTGGCTCTTTGGACCTGTGATGTGCAAAGTTTTT
GGTTCTTTTCTTACCCTGAACATGTTTGCAAGCATTTTTTTTATCACCTGCATGAGTGTT
GATAGGTACCAATCTGTCATCTACCCCTTTCTGTCTCAAAGAAGAAATCCCTGGCAAGCA
TCTTATATAGTTCCCCTTGTTTGGTGTATGGCCTGTTTGTCCTCATTGCCAACATTTTAT
TTTCGAGACGTCAGAACCATTGAATACTTAGGAGTGAATGCTTGCATTATGGCTTTCCCA
CCTGAGAAATATGCCCAATGGTCAGCTGGGATTGCCTTAATGAAAAATATCCTTGGTTTT
ATTATCCCTTTAATATTCATAGCAACATGCTATTTTGGAATTAGAAAACACTTACTGAAG
ACGAATAGCTATGGGAAGAACAGGATAACCCGTGACCAAGTCCTGAAGATGGCAGCTGCT
GTTGTTCTGGCCTTCATCATTTGCTGGCTTCCCTTCCATGTTCTGACCTTCCTGGATGCT
CTGGCCTGGATGGGTGTCATTAATAGCTGCGAAGTTATAGCAGTCATTGACCTGGCACTT
CCTTTTGCCATCCTCTTGGGATTCACCAACAGCTGCGTTAATCCGTTTCTGTATTGTTTT
GTTGGAAACCGGTTCCAACAGAAGCTCCGCAGTGTGTTTAGGGTTCCAATTACTTGGCTC
CAAGGGAAAAGAGAGAGTATGTCTTGCCGGAAAAGCAGTTCTCTTAGAGAAATGGAGACC
TTTGTGTCTTAA
Chromosome Location
X
Locus
Xq22-q23
External Identifiers
ResourceLink
UniProtKB IDP50052
UniProtKB Entry NameAGTR2_HUMAN
GenBank Gene IDU20860
GenAtlas IDAGTR2
HGNC IDHGNC:338
General References
  1. Martin MM, Elton TS: The sequence and genomic organization of the human type 2 angiotensin II receptor. Biochem Biophys Res Commun. 1995 Apr 17;209(2):554-62. [Article]
  2. Chassagne C, Beatty BG, Meloche S: Assignment of the human angiotensin II type 2 receptor gene (AGTR2) to chromosome Xq22-q23 by fluorescence in situ hybridization. Genomics. 1995 Jan 20;25(2):601-3. [Article]
  3. Koike G, Horiuchi M, Yamada T, Szpirer C, Jacob HJ, Dzau VJ: Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. Biochem Biophys Res Commun. 1994 Sep 30;203(3):1842-50. [Article]
  4. Tsuzuki S, Ichiki T, Nakakubo H, Kitami Y, Guo DF, Shirai H, Inagami T: Molecular cloning and expression of the gene encoding human angiotensin II type 2 receptor. Biochem Biophys Res Commun. 1994 May 16;200(3):1449-54. [Article]
  5. Martin MM, Su B, Elton TS: Molecular cloning of the human angiotensin II type 2 receptor cDNA. Biochem Biophys Res Commun. 1994 Nov 30;205(1):645-51. [Article]
  6. Lazard D, Briend-Sutren MM, Villageois P, Mattei MG, Strosberg AD, Nahmias C: Molecular characterization and chromosome localization of a human angiotensin II AT2 receptor gene highly expressed in fetal tissues. Receptors Channels. 1994;2(4):271-80. [Article]
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  9. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [Article]
  10. Vervoort VS, Beachem MA, Edwards PS, Ladd S, Miller KE, de Mollerat X, Clarkson K, DuPont B, Schwartz CE, Stevenson RE, Boyd E, Srivastava AK: AGTR2 mutations in X-linked mental retardation. Science. 2002 Jun 28;296(5577):2401-3. [Article]
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Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB05739CYT006-AngQbinvestigationalunknownDetails
DB01349TasosartanexperimentalunknownantagonistDetails
DB16266OlodanriganinvestigationalyesantagonistDetails
DB12548Sparsentanapproved, investigationalyesantagonistDetails