Ribonuclease PH

Details

Name
Ribonuclease PH
Synonyms
  • 2.7.7.56
  • RNase PH
  • tRNA nucleotidyltransferase
Gene Name
rph
Organism
Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG 12228)
Amino acid sequence
>lcl|BSEQ0020579|Ribonuclease PH
MNRPSGRAADQLRPIRITRHYTKHAEGSVLVEFGDTKVICTVSAESGVPRFLKGQGQGWL
TAEYGMLPRSTGERNQREASRGKQGGRTLEIQRLIGRSLRAALDLSKLGENTLYIDCDVI
QADGGTRTASITGATVALIDALAVLKKRGALKGNPLKQMVAAVSVGIYQGVPVLDLDYLE
DSAAETDLNVVMTDAGGFIEVQGTAEGAPFRPAELNAMLELAQQGMQELFELQRAALAE
Number of residues
239
Molecular Weight
25654.01
Theoretical pI
5.89
GO Classification
Functions
tRNA binding / tRNA nucleotidyltransferase activity / tRNA-specific ribonuclease activity
Processes
rRNA catabolic process / tRNA processing
General Function
Trna-specific ribonuclease activity
Specific Function
Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates.
Pfam Domain Function
Transmembrane Regions
Not Available
Cellular Location
Cytoplasmic
Gene sequence
>lcl|BSEQ0020580|Ribonuclease PH (rph)
ATGAATCGTCCCAGTGGCCGTGCCGCCGACCAGCTGCGCCCGATCCGCATCACCCGCCAT
TACACCAAGCACGCAGAAGGTTCGGTGCTGGTCGAGTTCGGCGATACCAAGGTGATCTGC
ACCGTCAGCGCCGAGTCCGGGGTGCCGCGCTTCCTCAAGGGCCAGGGCCAGGGTTGGTTG
ACCGCCGAGTACGGCATGCTGCCGCGCTCCACCGGCGAGCGTAACCAGCGCGAGGCCAGC
CGCGGCAAGCAGGGCGGTCGTACCCTGGAGATCCAGCGCCTGATCGGCCGCTCCCTGCGA
GCGGCGCTGGACCTCAGCAAGCTCGGCGAGAACACCCTGTACATCGACTGCGACGTGATC
CAGGCCGACGGCGGCACCCGCACCGCCTCAATCACCGGCGCCACCGTGGCGCTGATCGAC
GCCCTGGCGGTGCTGAAGAAGCGTGGCGCGCTCAAGGGCAATCCGCTGAAGCAAATGGTC
GCCGCCGTTTCCGTGGGCATCTACCAGGGCGTGCCGGTCCTCGACCTGGACTACCTGGAG
GATTCCGCCGCGGAAACCGACCTGAACGTAGTGATGACCGATGCCGGCGGCTTCATCGAG
GTGCAGGGAACCGCCGAAGGCGCGCCGTTCCGTCCCGCCGAGCTGAACGCCATGCTCGAA
CTGGCCCAGCAGGGCATGCAGGAGCTGTTCGAACTTCAGCGCGCCGCGCTGGCCGAATGA
Chromosome Location
Not Available
Locus
Not Available
External Identifiers
ResourceLink
UniProtKB IDP50597
UniProtKB Entry NameRNPH_PSEAE
GenBank Protein ID1079663
GenBank Gene IDU38241
General References
  1. MacGregor CH, Arora SK, Hager PW, Dail MB, Phibbs PV Jr: The nucleotide sequence of the Pseudomonas aeruginosa pyrE-crc-rph region and the purification of the crc gene product. J Bacteriol. 1996 Oct;178(19):5627-35. [Article]
  2. Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. [Article]

Drug Relations

Drug Relations
DrugBank IDNameDrug groupPharmacological action?ActionsDetails
DB03309N-cyclohexyltaurineexperimentalunknownDetails